Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06649461Enrolling by invitation
Ozone therapy and splint for carpal tunnel syndrome
This trial tests if adding ozone therapy to a wrist splint helps relieve mild-to-moderate carpal tunnel syndrome symptoms like numbness, tingling, and pain. It compares the combination to a splint alone.
KocaeliAges 18–65 - NCT06605612Enrolling by invitation
Falls risk test for people with muscle and nerve conditions
This study is creating a test to predict falls in people with neuromuscular disorders. You will fill out a questionnaire about your fall risk.
München, BavariaAges 18–65 - NCT06598709Enrolling by invitation
International study on breathing tube removal in ARDS
This study looks at how doctors safely remove breathing tubes from patients with lung injury (ARDS). It aims to find ways to improve decisions about when to take the tube out.
HiroshimaAges 16 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06342999Enrolling by invitation
Fetal heart valve procedure for underdeveloped left heart
This trial tests a procedure called fetal aortic valvuloplasty (opening the baby's heart valve while still in the womb) to help the left side of the heart grow better. It's for pregnant women whose babies have a narrow aortic valve and signs that the left heart may not develop fully.
Rochester, MinnesotaAges Up to 45 years - NCT06330324Enrolling by invitation
Reproductive choices for genetic skin conditions
This study looks at the choices families have when they carry a genetic skin condition. It aims to learn more about how prenatal testing and IVF with genetic testing can help.
Maastricht, LimburgAges Any age - NCT06303986Enrolling by invitation
Observation study for newborns with or without NAS
This study is collecting information from two groups of newborns: those with Neonatal Abstinence Syndrome (NAS, caused by drug exposure before birth) and healthy newborns. The goal is to see if an automated system makes it easier to gather data without extra tests or procedures.
Albuquerque, New MexicoAges Up to 4 weeks - NCT06240065Enrolling by invitation
Fiber food trial for short bowel syndrome
This study tests if adding high-fiber foods can help people with short bowel syndrome (a condition where part of the small intestine is missing or removed). You will be asked to eat fiber-rich foods and the study team will see how your body handles them.
Dallas, TexasAges 4 months–17 years - NCT06230887Enrolling by invitation
New treatment for moral injury in veterans
This study tests a new therapy for veterans struggling with moral injury—distress from events that go against personal values. It compares two treatment approaches to see which works better.
Little Rock, ArkansasAges 18 years+ - NCT06212661Enrolling by invitation
Study on migraine drugs and bladder symptoms
This study looks at how certain migraine treatments affect bladder symptoms like frequent or urgent urination. If you have hard-to-treat migraines and are starting a CGRP inhibitor or Botox injections, you may be able to join.
Cleveland, OhioAges 18 years+ - NCT05859997Enrolling by invitation
CAR-T cell therapy for active autoimmune disease flare-ups
This study tests an immune-cell treatment (CAR-T, called BRL-301) in people with certain autoimmune diseases that are active and hard to control. It may help your immune system calm down if standard treatments have not worked or your disease has returned.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT05674539Enrolling by invitationPhase 3
Less intense transplant regimen for AML or MDS patients
This trial tests whether a less intense chemotherapy and transplant plan can work for adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who are getting a stem cell transplant. It may help reduce transplant-related harm, especially in people considered higher risk due to age or other health factors.
Wuhan, HubeiAges 18 years+ - NCT05583305Enrolling by invitation
Study brain artery narrowing causes in adults with antiphospholipid syndrome
This study looks at how often the brain’s arteries become narrowed in people with antiphospholipid syndrome (APS), and why it happens. It may help you and doctors better understand the cause and how to detect it early using a brain MRI scan.
Hong KongAges 18 years+ - NCT05544721Enrolling by invitationPhase 4
Nerve-block pain study for thoracic outlet surgery
This trial tests whether a targeted numbing injection near the back helps reduce pain or improve comfort for people having first rib removal surgery for thoracic outlet syndrome. It’s a Phase 4 study, meaning it builds on earlier use of this pain-control approach to see how well it works in routine care.
Jacksonville, FloridaAges 18 years+ - NCT05308927Enrolling by invitation
Registry for children with Noonan syndrome on growth hormone
This trial is a real-world registry that collects information about children with Noonan syndrome who are treated with Norditropin (a growth hormone). It helps researchers understand how these children do over time in routine care.
AngersAges Any age - NCT05301361Enrolling by invitationPhase 1
Test of brain testing during stimulant treatment for ADHD
This trial checks whether a “NIH Toolbox” set of child-friendly tests can detect changes when stimulant medicine is used for ADHD. It may help doctors better measure how well stimulant treatment is working in people with intellectual disability.
Sacramento, CaliforniaAges 6–24 - NCT05212571Enrolling by invitation
IV esketamine to improve long-term pain in CRPS
This study looks at whether giving esketamine through a vein can help reduce long-term pain in people with complex regional pain syndrome (CRPS). You may be able to join if your CRPS diagnosis matches specific international criteria and you can safely take the study medicine.
Rotterdam, South HollandAges 18 years+ - NCT05026645Enrolling by invitation
After a chemical, biological, or nuclear disaster exposure
This trial studies how patients are medically managed after being exposed to a chemical, biological, radiological, or nuclear (CBRNE) attack. It may help improve care for people who are treated after these rare disasters, using real medical information recorded by hospital staff.
College Park, MarylandAges Any age - NCT04988256Enrolling by invitationEarly Phase 1
Test cyclosporine versus steroids for DRESS skin reaction
This trial compares two medicines—cyclosporine and steroid treatment—for a rare, serious drug reaction called DRESS. It aims to see which treatment controls the illness more safely and effectively.
Los Angeles, CaliforniaAges 18 years+ - NCT04880876Enrolling by invitationPhase 3
Oral IBS-D medicine trial for kids and teens
This trial tests whether an oral medicine (eluxadoline) can help children and teens with IBS-D, a condition that causes stomach pain and frequent loose stools. It’s a Phase 3 study, meaning it’s designed to confirm benefits and safety.
Corona, CaliforniaAges 6–17 - NCT04804293Enrolling by invitation
Testing a wrist scan for carpal tunnel before treatment
This study checks whether a special ultrasound scan can help assess carpal tunnel in one wrist (not both). The results may guide doctors’ understanding of the condition before you get a steroid shot or surgery.
Scottsdale, ArizonaAges 18–100 - NCT04189822Enrolling by invitation
Heart rhythm genetic registry and blood sample bio bank
This study is building a Canadian database and tissue/blood bank for people and families with inherited heart rhythm conditions (and some inherited heart muscle diseases). It collects consented health and genetic information to help researchers better understand who is at risk and how these conditions work.
Vancouver, British ColumbiaAges Any age - NCT04008173Enrolling by invitation
Survey study of acute heart attack symptoms
This study collects information about symptoms and experiences during acute coronary syndromes, which are sudden, serious heart events like heart attacks or unstable angina. It may help researchers understand patterns of care and symptoms to improve future treatment and support.
Bologna, BolognaAges 18 years+ - NCT03914664Enrolling by invitation
Brain and sensation study in adults with Tourette syndrome
This study looks at brain activity and how sensory experiences feel in adults with Tourette syndrome. It compares you to carefully matched adults without neurologic or psychiatric conditions to understand what is different in the brain.
Nashville, TennesseeAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.