Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04310644Recruiting
Study of nerve and connective-tissue symptoms in EDS and autonomic issues
This study collects information about how the body’s automatic nerves (autonomic nerves) affect symptoms like fast heart rate on standing, fatigue, and related conditions in people with Ehlers-Danlos syndrome. It also enrolls healthy volunteers to compare results, which may help doctors understand these conditions better and improve care.
Aachen, North Rhine-WestphaliaAges 18–80 - NCT06807723Recruiting
Understanding De Santo Shinawi syndrome with WAC gene changes
This study collects medical information from people who have a change in the WAC gene, which causes a rare condition called De Santo-Shinawi syndrome. It aims to better describe the symptoms and help doctors recognize it.
Clermont-Ferrand, AuvergneAges Any age - NCT07410325Recruiting
Health coach and AI app study for metabolic syndrome
This study tests if a health coach supported by an AI-powered smartphone app can help people improve their metabolic syndrome. It is designed for adults who are willing to use the app and follow a structured lifestyle program.
SingaporeAges 21–65 - NCT07412028Recruiting
Gene study in women with severe insulin resistance and PCOS
This study is looking for women with a type of severe insulin resistance linked to genetics, especially those who have PCOS or a condition called lipodystrophy. The goal is to better understand the genes involved so doctors can offer more targeted treatments.
ParisAges 18–45 - NCT06825377Recruiting
Comparing high-protein vs. standard nutrition for ICU patients
This trial tests whether a high-protein diet or standard protein diet is better for critically ill patients who are at risk for refeeding syndrome (dangerous shifts in fluids and minerals when starting nutrition after starvation). The goal is to see which type of nutrition helps recovery.
TehranAges 18–65 - NCT07378423Recruiting
Survey on signs of cancer at birth
This trial asks newly diagnosed children and young adults with certain types of cancer to fill out a questionnaire about signs of cancer present at birth. The answers may help improve early detection of childhood cancer.
BernAges Up to 21 years - NCT07355478Recruiting
Asia myelodysplastic syndrome registry study
This study is a registry, meaning it collects information about people with Myelodysplastic Syndrome (MDS) to help doctors learn more about the condition. If you join, you simply allow your existing medical data to be used for research. It does not involve any new treatments or tests.
SingaporeAges 18 years+ - NCT07350018RecruitingPhase 4
Comparing Two Surfactants for Premature Babies With Breathing Problems
This trial compares two types of surfactant (Calfactant and Poractant Alfa) given through a less invasive method to very premature babies with breathing problems. It aims to see if one works better at helping them breathe without needing a breathing tube.
BursaAges birth–6 hours - NCT07344714Recruiting
Predicting breathing help needs for newborns in NICUs
This study looks at newborns in a lower-level NICU to see which ones will need extra breathing support. The goal is to better predict which babies can be kept at their current hospital instead of being moved.
Rochester, MinnesotaAges 7 months–9 months - NCT07316127RecruitingPhase 2
Blood filtering for autoimmune long COVID
This trial tests if filtering certain antibodies from the blood can help people with long COVID who experience post-exertional malaise (PEM) and reduced function. It aims to see if this treatment reduces symptoms and improves daily life.
AmsterdamAges 18–65 - NCT06831253Recruiting
Platelet-Rich Plasma Injection for Severe Dry Eye
This trial tests whether an injection of a special concentrate from your own blood (platelet-rich plasma, or PRP) can help calm severe dry eye disease. It’s meant for people whose dry eye has not improved with other treatments.
Nice, Site Principal InvestigatorAges 18 years+ - NCT07285005RecruitingPhase 3
Study of an oral drug for venous, lymphatic, and certain overgrowth syndromes
This trial tests whether the study drug KP-001 can help reduce symptoms like pain, fatigue, or bleeding caused by certain vascular malformations (abnormal blood vessel growths) that can't be surgically removed or haven't responded to other treatments. It's for people age 2 and older with specific conditions such as common venous malformations, lymphatic malformations, or KTS/CLOVES syndrome.
Charleston, South CarolinaAges 2 years+ - NCT07284641RecruitingPhase 2
Stem cell transplant for immune disorders
This trial tests a stem cell transplant to treat common variable immunodeficiency (CVID) and other immune problems. It aims to replace a faulty immune system with a healthy one from a donor.
Pittsburgh, PennsylvaniaAges 5–40 - NCT07211308Recruiting
A study of spinal cord stimulation for chronic leg pain
This trial tests a type of spinal cord stimulation (DTM SCS) for people with chronic leg or foot pain caused by nerve damage (PSPS-T2). It aims to see if this treatment can safely reduce pain and improve daily life.
BrusselsAges Any age - NCT07178925Recruiting
Long-term study of antiphospholipid syndrome
This trial follows patients with antiphospholipid syndrome over time to learn more about the condition. It may help researchers understand how the disease progresses and how to better manage it.
RouenAges 18–75 - NCT06954103Recruiting
Stroke and heart health study for recent stroke patients
This study looks at how a moderate to severe stroke can affect your heart. It aims to understand the link between stroke and heart problems, which may help improve future care.
Wuhan, HubeiAges 18 years+ - NCT07156318Recruiting
Drumming lessons for children with Down syndrome
This study tests whether drumming lessons can help children with Down syndrome. It may help with coordination, focus, or mood.
Nashville, TennesseeAges 7–15 - NCT07146516Recruiting
Preventing retinal detachment in Stickler syndrome with laser
This study tests whether a preventative laser treatment can lower the risk of retinal detachment in people with Stickler syndrome. It's for those who have not yet had a retinal detachment and are healthy enough for the procedure.
Birmingham, AlabamaAges Any age - NCT06960369RecruitingPhase 1
Brain stimulation and probiotics for diarrhea-predominant IBS
This trial tests whether combining a type of brain stimulation (repetitive transcranial magnetic stimulation) with a probiotic tablet can help people with diarrhea-predominant irritable bowel syndrome. It aims to improve symptoms by targeting both the brain and the gut.
Suzhou, JiangsuAges 18–70 - NCT07102927Recruiting
Virtual reality training for stroke patients with neglect
This trial tests whether virtual reality exercises can help people with right-brain stroke overcome 'neglect' (trouble noticing things on their left side). It aims to improve daily function and quality of life.
SeoulAges 19–99 - NCT06373003Recruiting
Studying antiphospholipid syndrome without antibodies
This trial looks at people who have symptoms of antiphospholipid syndrome (APS) but test negative for the usual antibodies. It will compare these patients to those with positive antibody tests to better understand the condition and improve diagnosis and treatment.
Roma, RomeAges 18–65 - NCT07094776Enrolling by invitation
MG53 protein levels in women with PCOS
This study measures a protein called MG53 in the blood of women with and without PCOS to see if it could be a marker for the condition. If you have PCOS and are not taking certain medications, you may be able to join and help researchers better understand the disease.
Gaziosmanpaşa, IstanbulAges 18–45 - NCT06684782Recruiting
Restless leg syndrome in Thai Parkinson's patients
This trial is looking at how common restless leg syndrome is in people with Parkinson's disease in Thailand. It aims to better understand the link between the two conditions so doctors can improve care for people with both.
Bangkok, BangkokAges 18–80 - NCT07086599Recruiting
Sleep problems in psoriatic arthritis and SAPHO syndrome
This study looks at sleep problems in people with psoriatic arthritis or SAPHO syndrome. Participants will stay in the hospital for special sleep tests to understand their sleep issues better.
ParisAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.