Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06150599Recruiting
Sacral nerve stimulation for chronic pelvic pain
This study tests whether a pacemaker-like device placed near the tailbone can reduce long-term pelvic pain in women who haven't gotten relief from other treatments.
Royal Oak, MichiganAges 22–70 - NCT06419972Recruiting
Multimodal program for women in menopause transition
This study tests a program combining different therapies to help women during the menopause transition. It aims to improve symptoms and quality of life.
ValenciaAges 45–85 - NCT06765057RecruitingPhase 2/Phase 3
Probiotics for Depression and Metabolic Health
This trial tests whether taking a probiotic supplement can improve both depression symptoms and metabolic health (like waist size, blood sugar, and cholesterol) in people with major depression. It may be a good fit if you are already on an antidepressant and have signs of metabolic syndrome.
Riyadh, Riyadh RegionAges 18–65 - NCT06471946RecruitingPhase 1/Phase 2
Stem cell transplant for older patients with high-risk MDS
This trial tests a special conditioning regimen (VA) before a stem cell transplant for older patients with higher-risk myelodysplastic syndrome (MDS). It aims to make the transplant safer and more effective for this group.
Beijing, Beijing MunicipalityAges 70 years+ - NCT06466408Recruiting
Enzyme supplement and exercise in older adults
This trial is testing if taking a fruit and vegetable enzyme supplement can help older adults recover better after short, intense exercise using video games. You would exercise and take the supplement to see how it affects your muscles, breathing, and blood.
TainanAges 65 years+ - NCT07528261Recruiting
Support Group for Family Caregivers of Stroke Survivors
This study tests whether a support group using acceptance and commitment therapy (a type of counseling that helps people cope with stress) can reduce caregiver burden and distress. You would meet online with other people caring for stroke survivors.
Alameda, CaliforniaAges 40 years+ - NCT07471867RecruitingPhase 4
Testing a new stomach medicine for heart patients on clopidogrel
This trial tests if a new stomach acid medicine (Zastaprazan) affects how well clopidogrel works in heart patients who have had a stent placed. It aims to help people who need both clopidogrel and a stomach acid drug after a procedure.
Yongin-si, Gyeonggi-doAges 19 years+ - NCT07030023Enrolling by invitation
Diagnosing Wire Syndrome in people with fixed retainers
This trial looks at people who have a fixed orthodontic wire retainer to see if they have a condition called Wire Syndrome. You may be eligible if you have this retainer, are healthy, and have your dental records available.
Nice, Alpes MaritimesAges 18 years+ - NCT06408402Recruiting
Environment and tumor risk in SDHx carriers
This study looks at whether things in the environment (like chemicals or lifestyle) affect the risk of developing certain tumors in people who have a change in their SDHx gene. It compares people with the gene change who have had a related tumor to those who haven't.
AngersAges 18 years+ - NCT06979427Recruiting
Predicting heart artery blockages with CT and FFR
This study tests whether a CT scan combined with blood-flow measurements can better predict which heart artery blockages are serious. It may help avoid unnecessary invasive tests.
Shiraz, FarsAges 20–80 - NCT06450171Recruiting
Multi-cancer early detection test for people at high risk
This study tests a blood-based multi-cancer early detection (MCED) screening test in people with a high risk of cancer due to inherited gene changes or strong family history. The goal is to see if this test can find cancer early.
Boston, MassachusettsAges 22 years+ - NCT07413731Recruiting
Medication tapering with spinal cord stimulation
This trial tests how changing your pain medications while using a spinal cord stimulator affects your nervous system. It may help people with chronic lower back pain find the best way to manage their pain and reduce reliance on strong drugs.
WilrijkAges 18 years+ - NCT07411833Enrolling by invitation
Brain stimulation for stress and burnout in university staff
This study tests whether a gentle brain stimulation technique called tDCS can help reduce stress and burnout in university staff. It involves 10 sessions of treatment, and researchers will check if it improves how you feel at work.
Almada, Setúbal DistrictAges 18 years+ - NCT05665244Recruiting
Cryotherapy for long-lasting cough from nerve signals
This trial tests a cold-treatment procedure (cryotherapy) to treat a stubborn cough caused by nerve signaling (not infections or common allergy/acid problems). It may help people whose cough has lasted at least 8 weeks and who have already tried to rule out other causes.
Dallas, TexasAges 18 years+ - NCT05717218Recruiting
Testing special breathing monitoring during VV-ECMO in ARDS
This trial checks whether a special “breathing sensor belt” that watches breathing in real time can be used safely in adults with severe lung failure (ARDS) who are on a machine called VV-ECMO. It may help the care team better monitor ventilation while you’re critically ill.
ParisAges 18 years+ - NCT07301476Recruiting
Testing numbing medicine spread in a knee block
This trial checks how a numbing medicine moves during a common knee block for surgery. It may help doctors improve pain control after knee operations.
Boulogne-BillancourtAges 18 years+ - NCT07169487RecruitingPhase 1
Methylene Blue for Side Effects of Cancer Immunotherapy
This trial tests if methylene blue can help people who develop side effects called CRS or ICANS after treatments like CAR-T cells or bispecific antibodies. It is a first-in-human study to find a safe dose.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07281391Recruiting
Laser treatment for pigmentary glaucoma
This trial tests a laser procedure called DSLT to lower eye pressure in people with pigmentary glaucoma. It may offer a treatment option for those who have not had prior glaucoma surgeries.
Houston, TexasAges Any age - NCT06517199RecruitingPhase 3
Olanzapine for cancer-related appetite and weight loss
This trial tests whether the drug olanzapine can help improve appetite and reduce weight loss in people with advanced cancer who are not currently receiving chemotherapy or other anti-cancer treatment. It may be an option if you have lost weight and have little appetite.
BangkokAges 18 years+ - NCT06825260RecruitingPhase 4
PEG3350 vs Senna after urogynecologic surgery
This study compares two common laxatives to see which works better for preventing constipation after surgery for pelvic organ prolapse or stress urinary incontinence. It will help find the best way to keep you comfortable during recovery.
Syracuse, New YorkAges 18 years+ - NCT06664970Enrolling by invitationPhase 2
Treatment for MDS/MPN Overlap Syndrome
This study tests a combination of two drugs (azacitidine or ruxolitinib plus selinexor) for people with MDS/MPN overlap syndrome, a type of blood cancer. It aims to see if this treatment helps control symptoms and improve blood counts.
BeijingAges 18 years+ - NCT07248514Recruiting
Pilates for kids with backpack-related back pain
This study tests if Pilates exercises can help children aged 12-16 who have back pain and poor posture from carrying heavy backpacks.
Lahore, Punjab ProvinceAges 12–16 - NCT05008744Recruiting
Laser treatment for twin-to-twin transfusion using one shared placenta
This study tests a laser procedure that seals abnormal blood vessel connections in identical twins sharing one placenta (twin-to-twin transfusion syndrome). The goal is to improve outcomes by stopping unbalanced blood flow between the twins.
Seattle, WashingtonAges Any age - NCT06818994RecruitingPhase 1
Psilocybin therapy for low mood in advanced cancer
This trial tests if a medicine called psilocybin, given with talk therapy, can safely help people with advanced cancer who feel very demoralized. Demoralization is a deep sense of hopelessness or loss of meaning. The goal is to see if this treatment can improve your emotional well-being.
Kingston, OntarioAges 18–70
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.