Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,201 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06440525RecruitingPhase 2
Testing RSLV-132 for Sjögren's disease in women
This study tests an investigational drug called RSLV-132 in women with Sjögren's disease to see if it can reduce symptoms like fatigue and dryness. You may join if you've been diagnosed in the last 30 years and have persistent symptoms.
Chula Vista, CaliforniaAges 18–75 - NCT04456816RecruitingPhase 2
Drug test for IgA? No—anti-PLA2R positive immune kidney disease
This Phase 2 trial studies AP1189 in people with a specific immune-related kidney disease called iMN and very high urine protein. It aims to see whether the drug is safe and tolerable and if it can reduce protein in the urine.
AarhusAges 18–85 - NCT07496255Recruiting
Virtual reality for memory help after ICU confusion
This trial tests whether using virtual reality (VR) can help older adults recover their thinking and memory after a serious illness and confusion in the ICU. You may be eligible if you are 50 or older, spent time on a breathing machine, and had delirium in the ICU.
Indianapolis, IndianaAges 50 years+ - NCT06317233Enrolling by invitation
Team-based program for chronic pelvic pain in women
This research study tests a team-based program for women with ongoing pelvic pain. The goal is to see if a coordinated approach with different specialists can help manage pain and improve quality of life.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06377969Recruiting
Spinal cord stimulation for chronic pelvic pain
This study tests a device called a spinal cord stimulator — a small implant that sends mild electrical pulses to nerves in your spine — to see if it can reduce long-term pelvic pain that hasn't gotten better with other treatments.
Redwood City, CaliforniaAges 18 years+ - NCT06252948Recruiting
Gut bacteria study for POEMS and related plasma cell disorders
This study looks at the gut microbiome (the bacteria living in your digestive system) in people with POEMS syndrome, multiple myeloma, MGUS, amyloidosis, and healthy household members. It may help researchers understand how gut health relates to these conditions.
Rochester, MinnesotaAges 18 years+ - NCT01912313Recruiting
Testing nerve signals in gut samples from IBS patients
This study looks at how nerves behave in small gut tissue samples (biopsies) from people with irritable bowel syndrome (IBS) and healthy volunteers. The goal is to better understand IBS symptoms and what might be driving them.
Leuven, Vlaams-BrabantAges 18–99 - NCT06662188RecruitingPhase 1/Phase 2
Gene therapy for children with SHANK3-related condition
This trial tests a gene therapy called JAG201 for children with a SHANK3 mutation or 22q13.3 deletion, which causes Phelan-McDermid syndrome. The goal is to see if it can help with development and daily function.
Chicago, IllinoisAges 2–9 - NCT06691178Recruiting
Vaginal changes after CO2 laser therapy
This study looks at how CO2 laser therapy affects the vagina in people who have gone through menopause and have genitourinary symptoms like dryness or discomfort. It aims to understand the benefits and changes that happen after treatment.
Irvine, CaliforniaAges 18 years+ - NCT07231120RecruitingPhase 1
Testing SXRN injection for cancer-related weight loss
This trial tests a new injection called SXRN for people with advanced cancer who have lost weight and appetite (cancer cachexia). The goal is to see if it is safe and might help improve weight and appetite.
Beijing, Beijing MunicipalityAges 18–75 - NCT07695298RecruitingPhase 4
Testing faricimab for a rare eye disease linked to histoplasmosis
This trial tests a drug called faricimab (brand name Vabysmo) for treating abnormal blood vessel growth in the back of the eye, caused by a past infection with histoplasmosis. The goal is to see if it helps improve vision over 52 weeks.
Cincinnati, OhioAges 18 years+ - NCT07221695Enrolling by invitation
Pelvic vein treatment: foam plus glue vs foam plus coils
This trial compares two different methods for treating chronic pelvic pain caused by pelvic vein disorders. One method uses foam plus a medical glue, the other uses foam plus tiny metal coils. The goal is to find which approach works better.
Kafr ash Shaykh, Kafrelshaykh GovernorateAges 18–50 - NCT07686315Recruiting
Safer breathing with advanced monitoring on a ventilator
This trial is testing a new way to monitor your breathing while you are on a ventilator, to make it safer. It is for people who need a ventilator for reasons other than lung failure, like after a coma, injury, or severe infection.
Milan, LombardyAges 18 years+ - NCT07548203Recruiting
Treatments for Dark Spaces Between Teeth
This study tests different ways to fix dark triangular gaps that appear between teeth below the gum line. These gaps can affect how your smile looks and may trap food. The trial will compare treatment options and follow your results over 6 months.
CairoAges 18–50 - NCT07195149RecruitingPhase 3
Aspirin dose comparison after bypass surgery
This trial tests whether a lower dose of aspirin combined with another blood thinner (prasugrel) after bypass surgery is as safe and effective as a higher dose. It is for people with stable heart disease who are scheduled for bypass surgery and have not had a recent heart attack.
BialystokAges 18 years+ - NCT05995535RecruitingPhase 2
Pregabalin and Lofexidine for Opioid Withdrawal
This study tests whether combining two medications, pregabalin and lofexidine, can help people stop using opioids by easing withdrawal symptoms. It's for adults who use opioids heavily and want to switch to a non-addictive blocker medication.
Baltimore, MarylandAges 18 years+ - NCT07047183RecruitingPhase 2
A study of venetoclax and azacitidine before stem cell transplant for MDS
This trial tests a combination of two drugs (venetoclax and azacitidine) given before a stem cell transplant to see if it improves outcomes for people with a certain type of myelodysplastic syndromes (MDS) that is higher risk. If you have higher-risk MDS and are planning a stem cell transplant, this may be an option.
Changchun, JilinAges 18 years+ - NCT05651386Recruiting
Six-food elimination diet for meal-related stomach distress
This trial tests whether removing six common food groups helps people whose stomach symptoms get worse after meals. You would follow a structured diet plan and answer questionnaires to see if your symptoms improve.
LeuvenAges 18–70 - NCT06083129RecruitingPhase 3
Preventing GVHD after stem cell transplant in older adults
This trial tests two different medicines (ATG-thymoglobulin and ATLG-grafalon) to prevent graft-versus-host disease (GVHD) after a stem cell transplant. It is for older adults with certain blood cancers who have a matched unrelated donor.
AmiensAges 50–70 - NCT07560280Recruiting
Tinnitus from Jugular Vein Narrowing: Diagnosis and Surgery Study
This study evaluates whether neck vein narrowing causes a specific type of tinnitus (ringing in the ears) and tests surgical treatment. If you have persistent tinnitus and imaging shows a narrowed jugular vein, this trial may help determine if surgery could help.
Beijing, Beijing MunicipalityAges 18–75 - NCT06514209Recruiting
Muscle relaxation levels in severe ARDS patients
This study is testing whether different levels of muscle relaxation (called neuromuscular blockade) during breathing support can improve lung function in people with serious ARDS. It might help doctors choose the best relaxation level for patients on a breathing machine.
Nanjing, JiangsuAges 3 weeks–85 years - NCT06723730Recruiting
Mobilization and core strength for rotator cuff pain
This trial tests if adding a specific type of shoulder movement therapy and upper body core exercises can reduce pain and improve function in people with rotator cuff-related shoulder pain. It may help you if you have had shoulder pain for more than 6 weeks and it started after an injury.
Rawalpindi, Punjab ProvinceAges 18–65 - NCT06381414Recruiting
Childhood early oral aging: causes and effects on teeth
This study looks at why some young children have early signs of oral aging and how it affects their bite. It aims to find the causes and possible consequences for kids ages 3 to 6.
São Paulo, São PauloAges 3–6 - NCT06657846Recruiting
Quality of life and costs for people with VEXAS
This study looks at how VEXAS syndrome affects your daily life and finances. It aims to understand the challenges you face so doctors can better support you.
AnconaAges 18–99
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,201 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.