Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06883513Recruiting
Osteopathic therapy for long COVID symptoms
This trial tests if gentle hands-on treatment (osteopathic manipulative therapy) can help relieve long-lasting COVID symptoms like fatigue, brain fog, and body pain.
Louisville, KentuckyAges 18 years+ - NCT06886425Recruiting
Study of how azacytidine works in blood cancers
This study looks at how certain enzymes in your body affect the way a drug called azacytidine works against blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The goal is to better understand who might benefit most from this treatment.
MarseilleAges 18 years+ - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
San Francisco, CaliforniaAges 5 months–7 months - NCT07269847Recruiting
Beef-heavy diet study for adults with pre-diabetes
This study tests whether a diet rich in beef can improve metabolic health in adults with pre-diabetes or metabolic syndrome compared to a typical healthy U.S. diet. Eligible participants will follow one of two meal plans for several weeks.
Guelph, Ontario - onAges 18–74 - NCT07269665RecruitingEarly Phase 1
Gene therapy trial for children with BBS1 retinal degeneration
This early-phase trial tests a gene therapy called AXV-101 for children with vision loss caused by BBS1 genetic mutations. The goal is to see if it can help slow or stop retinal damage.
LondonAges 4–17 - NCT06198816Recruiting
Ultrasound and balloon treatment for old leg clots
This study tests a new way to treat long-standing blood clots in the leg using ultrasound waves and a balloon procedure. It aims to improve blood flow and reduce symptoms like swelling and pain for people who haven't gotten better with standard treatments.
Milan, ItalyAges 18–75 - NCT07272187Recruiting
Heat therapy for small pancreatic and adrenal tumors
This trial tests a new treatment that uses an endoscope (a thin, flexible tube with a camera) to deliver heat energy directly to certain small tumors in the pancreas or adrenal gland. It may be an option for people who cannot have surgery or whose tumors are growing slowly.
Herlev, Capital RegionAges 18 years+ - NCT07278843Recruiting
Understanding vision loss in Usher syndrome type 1B
This study follows people with Usher syndrome type 1B over time to learn how vision loss progresses. It also tests new ways to measure functional vision, which may help design future treatments.
Paris, Île-de-France RegionAges 3–75 - NCT07276035Recruiting
Brain-stomach circuits in chronic nausea
This study looks at how the brain and stomach communicate in people with chronic nausea. It uses a noninvasive brain stimulation method called TMS to understand brain activity. You may qualify if you have chronic nausea or are a healthy volunteer.
Pittsburgh, PennsylvaniaAges 21–60 - NCT07276542RecruitingPhase 2/Phase 3
Ketamine for phantom limb pain: a six-month outpatient study
This study tests whether ketamine, given as an outpatient treatment, can reduce phantom limb pain over six months. You would come to a clinic for multiple ketamine sessions, with at least a week between each session, and be followed for a year.
Sacramento, CaliforniaAges 18–65 - NCT07269743Recruiting
Aerosol therapy for ARDS patients on ventilators
This trial tests whether delivering medication through a ventilator mask (aerosol therapy) can help adults with ARDS breathe better. It is designed for patients who are already on a breathing machine.
Lucknow, Uttar PradeshAges 18 years+ - NCT07273838RecruitingPhase 2
SGLT2 inhibitor for acute heart and kidney failure
This study tests whether a medicine called an SGLT2 inhibitor (which lowers blood sugar and helps the kidneys) can improve outcomes for people with acute heart failure and kidney problems. Participation involves taking the study drug or a placebo for a short time.
New Haven, ConnecticutAges 18–85 - NCT07278570Recruiting
Tracking muscle stiffness with MRI during hands-on therapy for low back pain
This study uses a special MRI scan to see if hands-on therapy (manual therapy) helps reduce muscle stiffness and pain in people with chronic low back pain. It aims to find a better way to measure how well this treatment works.
Rochester, MinnesotaAges 18 years+ - NCT07270978RecruitingPhase 1
CD33-targeting cells for leukemia with leftover cancer cells
This trial tests a new treatment using special immune cells that target a protein called CD33 on leukemia cells. It's for people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) who still have small amounts of cancer cells left after other treatments.
Charlottesville, VirginiaAges 18 years+ - NCT06892223RecruitingPhase 2
Anti-NKG2A antibody for leukemia or MDS after half-matched transplant
This trial tests a drug that targets NKG2A, a protein that may help prevent cancer cells from hiding from the immune system. It is for people with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or related conditions who have already received a half-matched stem cell transplant (haploidentical transplant) with a specific anti-rejection drug plan.
Genova, GENOVAAges 18–99 - NCT06357780Recruiting
Comparing two breath-timing methods for breathing masks in adults
This study compares two ways of timing a breathing mask's support to match your own breaths. If you're in the ICU or ER and need help breathing for at least 2 more hours, this trial may test which method works better.
IzmirAges 18 years+ - NCT07264270RecruitingPhase 1
A new injection for long-term sciatica pain
This trial tests a new medicine called C-1101, given as a shot into the spine, to see if it safely reduces pain from chronic sciatica. It is for people who have not gotten enough relief from standard treatments.
Broadmeadow, New South WalesAges 18–65 - NCT07268859Recruiting
Fan to prevent ticagrelor-related shortness of breath
This study tests whether using a small fan can help reduce the shortness of breath (dyspnea) that some people feel when they first start taking the blood thinner ticagrelor after a heart attack.
Istanbul, AvcılarAges 18–65 - NCT07266259Recruiting
Levocarnitine plus myoinositol for PCOS and insulin resistance
This study compares two treatments for women with PCOS and insulin resistance who are having trouble getting pregnant. It tests if taking levocarnitine with myo-inositol works better than myo-inositol alone for improving hormone levels and insulin resistance.
Dhaka, ShahbagAges 18–40 - NCT07261826Recruiting
Long-term effects of fecal microbiota transplant
This study looks at how well fecal microbiota transplantation (FMT) works over time and checks its safety. If you have received at least one FMT for a qualifying condition, you may be able to participate.
Shanghai, Shanghai MunicipalityAges 3 years+ - NCT07262541Recruiting
Measuring airway opening pressure in children on ventilators
This study tests a simple way to measure the pressure needed to open the airways in children on a breathing machine. It may help doctors provide better breathing support for your child in the intensive care unit.
ParisAges Up to 17 years - NCT07265583Recruiting
Predicting lung injury in premature babies
This study looks at premature babies to see if we can predict lung injury early. It may help doctors provide better care for babies born early or with low birth weight.
PaviaAges 6 months–7 months - NCT05858307Recruiting
Testing AMH blood levels for PCOS and POI patients
This study looks at how a blood test called AMH (anti-Müllerian hormone) is used in people being seen for PCOS or POI (early ovarian failure). The goal is to understand whether AMH measurements are useful for care in clinics and fertility treatment settings.
Hong KongAges 10–44 - NCT02964637Recruiting
Tests to help diagnose frontotemporal dementia
This study looks at testing (including brain scans) to figure out what type of frontotemporal dementia or related language/speech condition a person has. It may help by making diagnoses more accurate, which can guide better care.
Toronto, OntarioAges 18–90
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.