Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,196 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05601726RecruitingPhase 1/Phase 2
Study of a new drug for hard-to-treat AML or high-risk MDS
This early study tests a new medicine (ABD-3001) to see if it’s safe and tolerable, how the body handles it, and whether it shows early signs of helping people with relapsed or hard-to-treat AML or high-risk MDS. It may be an option if standard treatments have already failed and you can’t receive a stem cell transplant.
Marseille, FranceAges 18 years+ - NCT05605314Recruiting
Study different types of dry eye in Sjögren’s
This study looks at patients with Sjögren’s-related dry eye to understand how different subtypes affect tear function and eye symptoms. It may help doctors better sort out dry eye types, which can guide more tailored care.
BeijingAges 18–80 - NCT05610436Recruiting
Long COVID patients: tracking symptoms and outcomes over time
This study follows people who have ongoing symptoms after COVID (“post-Covid condition”) to better understand how symptoms change and what factors affect recovery. It may help improve care for patients seen at a Long COVID support clinic.
Vandœuvre-lès-Nancy, Grand EstAges 18 years+ - NCT05618054Recruiting
Explaining nerve signals in teens with POTS
This study looks at how a specific brain–vagus nerve connection works in people with POTS and tries to understand what happens over time. It may help researchers better explain symptoms and other health problems that can occur with POTS.
Richmond, VirginiaAges 12–21 - NCT05623150Recruiting
Biopsy-based study for alcohol and metabolic liver disease
This trial studies people with liver disease linked to alcohol use or metabolic syndrome (a cluster of conditions like weight gain and insulin resistance). It uses recent standard-of-care liver biopsy results to better understand these chronic liver problems and how they relate to cancer risk.
NiceAges 18 years+ - NCT05623722Recruiting
Nerve block to help organ function in severe gut sepsis
This trial studies whether an erector spinae plane nerve block (a pain-control injection near the spine) can improve organ health in adults with sepsis caused by acute gut injury. It’s meant for people sick enough to need ICU care for several days.
Guangzhou, GuangdongAges 18 years+ - NCT05626296Recruiting
Blood-sample study of stroke patterns using multiple tests
This study looks at blood and lab “molecular” patterns in people who have had an ischemic stroke (a blocked blood vessel). It aims to understand differences between people labeled as having “phlegm-heat syndrome” versus not, which may help future stroke care. You may be eligible if your stroke was recent and confirmed by MRI.
Beijing, Beijing MunicipalityAges 50–80 - NCT05633693Recruiting
Exercises to help children with fainting and blood-pressure drops
This study tests whether teaching special standing/balance movements can reduce fainting episodes in children who have recurring vasovagal fainting or certain forms of POTS. It may help your child feel more stable when standing and improve symptoms, while researchers measure balance and “counterpressure” responses during the tests.
Burnaby, British ColumbiaAges 6–18 - NCT05633706Recruiting
Testing a capsule to study gut bacteria in the small intestine
This study tests the SIMBA capsule to learn how gut bacteria (dysbiosis) relate to digestive conditions. It may help researchers better understand these conditions and how the capsule can be used safely.
Calgary, AlbertaAges 18–80 - NCT05636514RecruitingPhase 1
Testing epigenetic and sensitizer treatment for AML and MDS
This early-phase trial tests whether a combination of targeted medicines can improve outcomes in people with higher-risk MDS or certain types of AML or CMML. It’s designed to find the safest dose and learn if the treatment can help the cancer respond.
Sydney, New South WalesAges 18 years+ - NCT05638269Recruiting
Study of gut bacteria in people with serious long-term illness
This study looks at the types of gut bacteria in people living in certain parts of China who have serious long-term (chronic) illnesses. The goal is to better understand how gut bacteria differ and may help doctors in the future tailor care.
Chaoyang, Beijing MunicipalityAges 18–75 - NCT05640752Recruiting
Testing whether better heart imaging planning reduces scans
This trial studies the best way to decide when people need heart imaging tests, with the goal of doing fewer unnecessary scans. It may help patients by avoiding extra radiation and tests while still keeping care safe and appropriate.
Beijing, Beijing MunicipalityAges 30–90 - NCT05640635Recruiting
Testing inflammation changes in people on ECMO
This study looks at inflammation during ECMO (a heart-lung bypass machine) and while people are being weaned off it. It may help doctors better understand which patients are improving safely during ECMO and when to reduce support.
Tübingen, Baden-WurttembergAges 18 years+ - NCT05644522Recruiting
At-home brace study for leg support and walking
This study tests an at-home wearable activity monitor and brace-related walking support for people who already use a knee-ankle-foot brace. It may help researchers understand how brace use and day-to-day movement relate to walking ability.
Chicago, IllinoisAges 18–89 - NCT05646394Recruiting
Registry for blood-clot prevention plans in arterial antiphospholipid syndrome
This study keeps a registry to follow people with antiphospholipid syndrome (APS) who have had arterial blood clots (like stroke). It collects information about the treatment approach your clinician chooses to see how different antithrombotic regimens may perform and be tolerated.
Buenos Aires, Buenos Aires F.D.Ages 18 years+ - NCT05646849Recruiting
App-based support to keep exercising after heart rehab
This study tests whether a phone app can help people keep up physical activity after cardiac rehabilitation. If you can use a smartphone and internet, the app support may make it easier to stay active after your rehab program.
CholetAges 18 years+ - NCT05650905Recruiting
Eye and blood-vessel function study after COVID-19
This study measures how well the nerves in your retina and the tiny blood vessels in your eye “couple” (work together) after COVID-19. It may help researchers understand eye-related effects of COVID-19 and long COVID, and how these processes change over time.
Vienna, State of ViennaAges 18 years+ - NCT05651724Recruiting
MASH screening study for people with diabetes or obesity
This study screens participants for MASH (a type of liver fat inflammation) using information about your health and risk factors. It may help you and your care team learn whether you could have MASH and need follow-up.
Brussels, Vlaams-brabantAges 18–75 - NCT05651919Recruiting
Blood test study to understand diabetic heart weakness
This study measures immune cells from your blood to find markers (biomarkers) that may explain or predict diabetic cardiomyopathy, a type of heart condition linked to diabetes. You may benefit mainly by being closely monitored and contributing to research that could improve future diagnosis or risk tracking.
BronAges 40–85 - NCT05652621Recruiting
Probiotics for people with ulcerative colitis symptoms
This study looks at whether probiotic pellets help people with inflammatory bowel disease, specifically ulcerative colitis. It may help improve gut symptoms, but the trial will test how well probiotics work for participants like you.
Xinxiang, HenanAges 18–80 - NCT05656365Recruiting
Study of genes and immunity in PFAPA and other tonsil problems
This study looks at genetic markers and immune system patterns in people with PFAPA (periodic fevers with mouth sores and throat/neck gland symptoms) or similar tonsil problems. It may help researchers understand why these conditions happen and how they might be better diagnosed or treated.
Washington D.C., District of ColumbiaAges 1 month–99 years - NCT05663008Recruiting
Testing nerve-to-muscle signal changes to diagnose movement diseases
This study measures how nerves communicate with muscles, using recordings and gels. It aims to spot early, personalized signs of conditions like ALS and related diseases, and to improve diagnosis.
Dublin, LeinsterAges 18 years+ - NCT05664867Recruiting
Program study for hereditary breast or colon cancer counseling in clinics
This study helps clinics roll out cancer genetic counseling services for people who may have inherited cancer risk. If you may need genetic testing for hereditary breast or colon cancer, you can be interviewed about your experience with these services.
Chicago, IllinoisAges 25 years+ - NCT05671757RecruitingPhase 1/Phase 2
Daratumumab for primary antiphospholipid syndrome
This early-phase study tests daratumumab, an immune-targeting drug, for people with primary antiphospholipid syndrome (APS). It aims to see whether it can reduce APS activity and improve outcomes while you continue your usual blood-thinning treatment.
Baltimore, MarylandAges 18–65
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,196 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.