Clinical trials
Drug Use clinical trials
Below are recruiting drug use clinical trials, each written for real people, not researchers. We’re tracking 154 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT06156683Recruiting
Kesimpta pregnancy safety study using real-world data
This study looks at the safety of Kesimpta (a multiple sclerosis medication) during pregnancy. It compares outcomes for women who took Kesimpta or other MS drugs while pregnant to those who did not.
BaselAges 18 years+ - NCT06084520Recruiting
Pain questionnaire study for opioid and non-opioid patients
This study tests two questionnaires for people with long-term pain. Researchers want to see if the tools work well for both those taking opioids and those who are not. Your answers can help improve pain care.
Uppsala, UpplandAges 18–75 - NCT06707532Recruiting
Muscle relaxants for safer heart rhythm treatment
This study tests if giving muscle relaxants before a heart ablation procedure can protect muscles from damage. Ablation uses energy to fix irregular heartbeats, and muscle relaxants might make it safer.
Wroclaw, Lower Silesian VoivodeshipAges 18–90 - NCT04939623RecruitingPhase 2
Probenecid to ease opioid withdrawal symptoms while tapering
This Phase 2 study tests whether probenecid can lessen discomfort from opioid withdrawal in adults who are gradually lowering their opioid pain medicine. If it works, it may make tapering feel more tolerable and safer.
Calgary, AlbertaAges 18–80 - NCT07012148Recruiting
Seizure forecasting with EEG and wearables for epilepsy
This study tests a wearable device that records brain waves to help predict and track seizures in people with temporal lobe epilepsy. It may help you better understand your seizure patterns and reduce uncertainty.
Rochester, MinnesotaAges 18–75 - NCT05538910Recruiting
Study brain links between depression and substance use
This study uses brain imaging and questionnaires to understand how substance use and depression are connected in the brain. It may help researchers identify biological patterns that could guide better treatments in the future.
Baltimore, MarylandAges 18–60 - NCT06297499RecruitingPhase 1
Testing ondansetron to prevent itching after C-section
This trial tests if giving ondansetron before spinal anesthesia can prevent itching that often happens after a C-section. It may help you feel more comfortable during recovery.
Detroit, MichiganAges 18–50 - NCT06324201Recruiting
Long-term safety of a new ablation system for paroxysmal AF
This study tests a new system (QDOT MICRO and VISITAG SURPOINT) used during a catheter ablation procedure to treat atrial fibrillation (AF). It aims to see how safe and effective it is over the long term for people whose AF comes and goes and hasn't been controlled by medication.
Birmingham, AlabamaAges 18 years+ - NCT06075485Recruiting
Ketogenic diet for drug-resistant epilepsy in children
This study looks at how well the ketogenic diet (a high-fat, low-carb diet) works for children with epilepsy that doesn't improve with standard medicines. It uses a special product called KetoCal to help maintain the diet and tracks results in real life.
LilleAges 5 months–18 years - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05957848RecruitingPhase 2
Guanfacine for teens with cannabis use problems
This Phase 2 study tests whether extended-release guanfacine can reduce cannabis use in adolescents and young adults. It may help by targeting brain pathways that can drive cravings or continued use.
Parkville, VictoriaAges 12–25 - NCT06115746Recruiting
A drug education program for middle and high school students
This study tests a program called iDECIDE, which helps students who have had a substance use issue at school. The program aims to provide education and support instead of punishment. Participants will attend up to 9 online study visits over about a year.
Boston, MassachusettsAges 9–22 - NCT07230847Recruiting
Healing of drug-coated vs. standard stents in high-bleeding-risk patients
This trial compares two types of stents (a drug-coated stent and a standard drug-eluting stent) in people with acute coronary syndrome who also have a high risk of bleeding. It uses a special camera to look at how the artery heals one month after the stent is placed.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07491380Recruiting
Blood monitoring for breast cancer drugs at home
This study tests a finger-prick blood test you can do at home to check levels of your breast cancer medication (ribociclib, abemaciclib, or palbociclib). The goal is to make monitoring easier and more convenient.
ParisAges 18 years+ - NCT06409884Recruiting
Amoxicillin allergy testing trial
This trial is testing a new way to diagnose allergies to amoxicillin, a common antibiotic. It may help people who think they might be allergic to amoxicillin find out for sure.
Edegem, AntwerpAges 6 years+ - NCT06759623Recruiting
Lung function and anesthesia in bariatric surgery
This study checks how well your lungs work after you receive anesthesia (sleep medicine) for weight-loss surgery. It will help doctors choose the best anesthetic for people with obesity.
GdanskAges 18 years+ - NCT06860607RecruitingPhase 1
Environment and Alcohol: A Pilot Study
A pilot study exploring the interaction between environment and alcohol consumption in individuals with alcohol use disorder (AUD), using smartphone-based ecological momentary assessment (EMA).
Baltimore, MarylandAges 21–100 - NCT07344363Recruiting
Prostate cancer hormone drug level monitoring study
This study looks at how levels of common prostate cancer hormone treatments (abiraterone, apalutamide, darolutamide, or enzalutamide) stay in your blood over time. By checking drug levels, doctors hope to personalize dosing to make treatment safer and more effective.
Aviano, PordenoneAges 18 years+ - NCT06214195RecruitingPhase 3
Shengmai San to prevent heart damage from breast cancer therapy
This trial tests if a traditional Chinese medicine called Shengmai San can protect the heart during chemotherapy and targeted therapy for HER2-positive breast cancer. Patients take the supplement alongside standard treatment to see if it reduces the risk of heart problems.
Hangzhou, ZhejiangAges 18 years+ - NCT07662213RecruitingPhase 3
Elecoglipron vs semaglutide for type 2 diabetes
This study tests an experimental diabetes pill (elecoglipron) to see if it works as well as a current medicine, semaglutide, for people with type 2 diabetes who also have heart risk factors. It aims to help better control blood sugar and weight.
Birmingham, AlabamaAges 18 years+ - NCT05735301Recruiting
MRI blood-flow scan-guided treatment within 6–24 hours after stroke
This trial looks at whether using an MRI blood-flow (perfusion) scan to help choose treatment improves outcomes for certain large-vessel strokes. You must be treated within 6–24 hours after symptoms start, with specific scan and blood test findings.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06793293Enrolling by invitation
Laser therapy for c-section incision pain
This trial tests if a high-level laser can reduce pain and help healing after a cesarean section. If you've had a C-section and have incision pain, this treatment may offer relief without medication.
CairoAges 20–40 - NCT07432867RecruitingPhase 1/Phase 2
Gene therapy for severe sickle cell disease in teens and adults
This trial tests a new gene therapy for sickle cell disease. It uses your own blood stem cells (collected from bone marrow) that are modified in a lab to help produce healthy red blood cells, then given back to you after a short chemotherapy. The goal is to reduce or stop severe complications like pain crises and lung problems.
Paris, Île-de-France RegionAges 12–35
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Common questions
- Are there clinical trials for drug use?
- Yes. Clin2 currently lists 154 recruiting drug use studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a drug use trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a drug use trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.