Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,360 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04161066RecruitingPhase 1
Psilocybin plus buprenorphine to help opioid use disorder symptoms
This Phase 1 study tests how adding psilocybin to a standard opioid treatment (buprenorphine-naloxone) affects recovery and symptoms in people with moderate-to-severe opioid use disorder. It may help researchers understand whether this combination is safe and beneficial alongside medication for opioid withdrawal and cravings.
Madison, WisconsinAges 21–65 - NCT04201704Recruiting
Less IV fluids for children after trauma
This trial studies whether giving children less fluid through a vein after serious injury helps them recover safely. Children are enrolled soon after arrival to the ICU so the team can compare outcomes between different fluid amounts.
Buffalo, New YorkAges 6 months–15 years - NCT04234971RecruitingPhase 4
Compare costs of bone grafting for cleft jaw repair
This study looks at whether alveolar bone graft surgery is cost-effective for people with cleft lip and palate. It may help clinics choose the most practical approach for the best outcomes while managing overall costs.
Houston, TexasAges 6–15 - NCT04182984Recruiting
Compare immunosuppressant medicines for eye-only myasthenia gravis
This real-world study looks at how different immunosuppressant medicines work for people with non-thymoma ocular myasthenia gravis (eye symptoms due to MG). It may help doctors understand which treatments control symptoms best in everyday care.
Xi'an, ShaanxiAges 18–75 - NCT03957928Recruiting
Mango pulp study for hunger and heart-health markers
This study tests whether eating fresh mango pulp can make you feel fuller (less hungry) and improve “heart-health” measurements. It may help people who are interested in diet changes, especially those with higher body weight and related health risks.
San Diego, CaliforniaAges 18–55 - NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Phoenix, ArizonaAges 18 years+ - NCT04031508Enrolling by invitationPhase 2
Omega-3 in an IV for newborns with breathing circulation problems
This trial tests whether giving an omega-3 fat medicine through an IV (along with standard care) improves breathing and blood-flow problems in newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension. It may help reduce strain on the lungs and heart by targeting inflammation and blood-vessel changes.
Mexico City, Mexico CityAges 1 hour–2 weeks - NCT04142437Recruiting
Tracking how larotrectinib works for NTRK fusion cancers in routine care
This study follows people with cancers that have an NTRK gene fusion to learn how safe and effective larotrectinib is during everyday treatment. It may help confirm whether this medicine works well in real-world patients and side effects stay manageable.
Mesa, ArizonaAges Any age - NCT04115267Recruiting
Registry study tracking side effects from radiation and medicines
This study follows people with cancer to better understand which treatments cause certain side effects when radiation is combined with targeted (molecular) medicines. Your participation may help doctors predict and manage side effects more safely in the future.
Montreal, QuebecAges 18 years+ - NCT04055428RecruitingPhase 2
Testing a hormone supplement to improve heart and metabolic health
This study tests whether adding a natriuretic peptide medicine improves heart health and metabolism in Black adults. It may help with blood pressure and related health markers, but you must meet specific health and safety criteria.
Birmingham, AlabamaAges 18 years+ - NCT04053478Recruiting
Testing common blood-pressure drugs on uterine and umbilical muscle
This study tests how several medicines used for blood pressure affect muscle “tightening” in tissue taken during planned C-sections. It’s an in-vitro (lab) study, so it mainly helps doctors understand how to prevent weak uterine contractions (uterine atony) during delivery.
Toronto, OntarioAges 19–40 - NCT04096430Recruiting
Goal-setting program for children in physical or occupational therapy
This trial tests a child-friendly goal-setting approach during pediatric rehabilitation (physical therapy and/or occupational therapy). It may help children and families plan realistic goals that make therapy more meaningful and effective.
Calgary, AlbertaAges 5–12 - NCT04137939Recruiting
Smart exercise program for seniors to improve balance
This trial tests whether an internet-connected (“smart”) exercise program can help adults age 50+ move safely and improve exercise/balance. It may help seniors who currently do not have major movement problems, heart conditions, or recent dizziness-related balance issues.
Tainan, TaiwanAges 50 years+ - NCT04141020RecruitingPhase 2
Sirolimus study for unruptured brain aneurysms after surgery
This Phase 2 study tests whether sirolimus, a medicine that changes immune and growth signals, can change what’s happening inside the tissue of unruptured brain aneurysms after a procedure. Researchers hope these molecular changes may help understand how to improve aneurysm outcomes.
Miami, FloridaAges 18 years+ - NCT04101188Recruiting
Study how extra potassium affects blood vessels
This study looks at how eating more potassium may protect blood vessels in healthy people. You may be eligible if you have normal blood pressure and a normal heart rhythm test, and you do not have certain health conditions.
Newark, DelawareAges 18–45 - NCT04096586Recruiting
Study tests how watermelon affects fullness and digestion
This study looks at whether eating watermelon changes how full you feel and how your digestion works. It’s for generally healthy people and skips those with certain health factors or who can’t eat watermelon safely.
San Diego, CaliforniaAges 10–55 - NCT04107077RecruitingPhase 2
HIPEC surgery plus chemotherapy for advanced stomach cancer
This study tests whether a specialized surgery called HIPEC (heat-treated chemotherapy placed in the belly) can improve outcomes for people with advanced stomach cancer that has reached the lining of the abdomen. It’s given after you’ve already had standard chemotherapy, aiming to better control disease in the belly.
Chicago, IllinoisAges 18 years+ - NCT03375866Recruiting
Mixed nuts trial to help you feel full and manage weight
This trial tests whether eating a mix of nuts helps people feel full longer (satiety) and manage weight. It may be most helpful if you are trying to improve weight control and can safely eat nuts.
San Diego, CaliforniaAges 18–55 - NCT03380195Recruiting
Watermelon juice study on heart recovery and muscle soreness
This study tests whether drinking watermelon juice affects how quickly your heart rate returns to normal after exercise and how sore your muscles feel afterward. It’s for generally healthy adults and may help researchers understand how diet changes exercise recovery.
San Diego, CaliforniaAges 21–50 - NCT03956602Recruiting
Snack choices and their effect on blood sugar
This trial studies how different snack types affect quick changes in blood sugar and insulin. It may help researchers understand which snacks cause smaller or larger spikes after eating.
San Diego, CaliforniaAges 18–55 - NCT03380221Recruiting
Watermelon eating study for fullness and heart health markers
This study tests whether eating fresh watermelon changes how full you feel and affects markers related to heart and metabolic health. It’s aimed at adults who fit certain age and body-size ranges and can follow the study’s food rules.
San Diego, CaliforniaAges 18–55 - NCT03884075RecruitingPhase 2
Semaglutide study for fatty liver and how sugar affects the liver
This Phase 2 study tests how semaglutide (a diabetes medication also used for weight) affects fatty liver and the liver’s response to sugar. It may help people with non-alcoholic fatty liver disease understand whether the drug improves liver fat and related changes.
Bethesda, MarylandAges 18–100 - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,360 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.