Clinical trials
Effectiveness clinical trials
Below are recruiting effectiveness clinical trials, each written for real people, not researchers. We’re tracking 6,374 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04137939Recruiting
Smart exercise program for seniors to improve balance
This trial tests whether an internet-connected (“smart”) exercise program can help adults age 50+ move safely and improve exercise/balance. It may help seniors who currently do not have major movement problems, heart conditions, or recent dizziness-related balance issues.
Tainan, TaiwanAges 50 years+ - NCT04055428RecruitingPhase 2
Testing a hormone supplement to improve heart and metabolic health
This study tests whether adding a natriuretic peptide medicine improves heart health and metabolism in Black adults. It may help with blood pressure and related health markers, but you must meet specific health and safety criteria.
Birmingham, AlabamaAges 18 years+ - NCT04141020RecruitingPhase 2
Sirolimus study for unruptured brain aneurysms after surgery
This Phase 2 study tests whether sirolimus, a medicine that changes immune and growth signals, can change what’s happening inside the tissue of unruptured brain aneurysms after a procedure. Researchers hope these molecular changes may help understand how to improve aneurysm outcomes.
Miami, FloridaAges 18 years+ - NCT04101188Recruiting
Study how extra potassium affects blood vessels
This study looks at how eating more potassium may protect blood vessels in healthy people. You may be eligible if you have normal blood pressure and a normal heart rhythm test, and you do not have certain health conditions.
Newark, DelawareAges 18–45 - NCT04115267Recruiting
Registry study tracking side effects from radiation and medicines
This study follows people with cancer to better understand which treatments cause certain side effects when radiation is combined with targeted (molecular) medicines. Your participation may help doctors predict and manage side effects more safely in the future.
Montreal, QuebecAges 18 years+ - NCT04096586Recruiting
Study tests how watermelon affects fullness and digestion
This study looks at whether eating watermelon changes how full you feel and how your digestion works. It’s for generally healthy people and skips those with certain health factors or who can’t eat watermelon safely.
San Diego, CaliforniaAges 10–55 - NCT04107077RecruitingPhase 2
HIPEC surgery plus chemotherapy for advanced stomach cancer
This study tests whether a specialized surgery called HIPEC (heat-treated chemotherapy placed in the belly) can improve outcomes for people with advanced stomach cancer that has reached the lining of the abdomen. It’s given after you’ve already had standard chemotherapy, aiming to better control disease in the belly.
Chicago, IllinoisAges 18 years+ - NCT03375866Recruiting
Mixed nuts trial to help you feel full and manage weight
This trial tests whether eating a mix of nuts helps people feel full longer (satiety) and manage weight. It may be most helpful if you are trying to improve weight control and can safely eat nuts.
San Diego, CaliforniaAges 18–55 - NCT03380195Recruiting
Watermelon juice study on heart recovery and muscle soreness
This study tests whether drinking watermelon juice affects how quickly your heart rate returns to normal after exercise and how sore your muscles feel afterward. It’s for generally healthy adults and may help researchers understand how diet changes exercise recovery.
San Diego, CaliforniaAges 21–50 - NCT03956602Recruiting
Snack choices and their effect on blood sugar
This trial studies how different snack types affect quick changes in blood sugar and insulin. It may help researchers understand which snacks cause smaller or larger spikes after eating.
San Diego, CaliforniaAges 18–55 - NCT03380221Recruiting
Watermelon eating study for fullness and heart health markers
This study tests whether eating fresh watermelon changes how full you feel and affects markers related to heart and metabolic health. It’s aimed at adults who fit certain age and body-size ranges and can follow the study’s food rules.
San Diego, CaliforniaAges 18–55 - NCT03884075RecruitingPhase 2
Semaglutide study for fatty liver and how sugar affects the liver
This Phase 2 study tests how semaglutide (a diabetes medication also used for weight) affects fatty liver and the liver’s response to sugar. It may help people with non-alcoholic fatty liver disease understand whether the drug improves liver fat and related changes.
Bethesda, MarylandAges 18–100 - NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT03887715Recruiting
VNS device for long-term depression that hasn’t improved
This trial studies whether a vagus nerve stimulation (VNS) device can reduce symptoms of treatment-resistant depression. Participants either receive the VNS treatment or a no-stimulation control, to compare safety and effectiveness.
Birmingham, AlabamaAges 18 years+ - NCT03980457Recruiting
Exoskeleton walking therapy for stroke recovery
This trial studies whether assisted walking training with an exoskeleton can improve recovery after stroke, especially for walking and daily function. You may be offered therapy once you are medically stable, able to stand, and able to participate safely.
Oklahoma City, OklahomaAges 18–90 - NCT03906253Recruiting
Laser treatment to prevent skin growth in older adults
This trial tests whether a type of laser treatment can help protect older adults’ skin from turning actinic keratosis (a sun-related precancer) into more serious skin problems. It focuses on the forearms and may help reduce future skin damage while checking safety and comfort.
Dayton, OhioAges 60 years+ - NCT04025359RecruitingEarly Phase 1
Test dronabinol for pain responses in people on opioid treatment
This early-stage study tests whether dronabinol (a form of THC) changes pain perception in people with opioid use disorder who are already stable on methadone or buprenorphine. It may help researchers understand whether this treatment affects pain and drug-related outcomes in a safer, controlled way.
West Haven, ConnecticutAges 18–70 - NCT03930810Enrolling by invitation
Study of PFIC types and how bile diversion affects outlook
This study looks at different genetic liver conditions called PFIC and follows how they progress over time. It also studies whether a procedure called biliary diversion may improve symptoms or long-term outcomes.
Groningen, Provincie GroningenAges birth–65 years - NCT03984591Enrolling by invitationPhase 4
Compare spironolactone vs eplerenone for heart failure patients
This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.
CopenhagenAges Any age - NCT03886961Recruiting
Reflux band device trial for lung transplant recipients
This trial tests whether a Reflux Band™ placed around the upper swallowing tube area can reduce reflux (stomach acid coming up) in people who have had a lung transplant. If reflux is causing discomfort or lung irritation, reducing it may help you stay stable after transplant.
Gainesville, FloridaAges 18–80 - NCT03934905RecruitingPhase 1/Phase 2
Sulforaphane supplement to protect the heart during doxorubicin
This trial tests whether a nutritional supplement called sulforaphane (SFN) can help protect heart function in people with breast cancer who are receiving doxorubicin (a chemotherapy that can affect the heart). Participants take caplets and have heart and safety monitoring to see if the supplement reduces heart-related side effects.
Lubbock, TexasAges 18–89 - NCT03883412RecruitingPhase 4
Exercise and liraglutide for type 2 diabetes
This study tests if combining exercise with a drug called liraglutide improves blood vessel health and insulin sensitivity in people with type 2 diabetes. It looks at whether these treatments work better together or alone.
Charlottesville, VirginiaAges 21–60 - NCT03878706Recruiting
Testing diabetes medicines on heart risk and heart failure
This trial studies how diabetes medicines (GLP-1 and SGLT2, alone or together) affect the heart in people with type 2 diabetes who are at higher cardiovascular risk and have heart failure with preserved pumping function. It may help find safer or more effective ways to reduce heart problems.
Athens, AtticaAges 45–80 - NCT03926403Recruiting
Hypnosis support for anxiety during face surgery
This trial looks at whether guided hypnosis can improve how people feel about having face surgery performed with numbing medicine (local anesthesia). If you’re experiencing significant anxiety beforehand, hypnosis support may help you feel more comfortable during your outpatient procedure.
AmiensAges 18 years+
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Common questions
- Are there clinical trials for effectiveness?
- Yes. Clin2 currently lists 6,374 recruiting effectiveness studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a effectiveness trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a effectiveness trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.