Clinical trials · Raleigh–Durham, NC
Epilepsy clinical trials in Raleigh–Durham
We’re tracking 15 recruiting epilepsy studies with a site in or near Raleigh–Durham — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Raleigh–Durham
- NCT07594119RecruitingPhase 3
Testing RAP-219 to reduce seizures in focal epilepsy
This study tests a new medication called RAP-219 to see if it can reduce seizure frequency in adults with focal epilepsy (seizures starting in one area of the brain). You'll take the medication alongside your current seizure drugs and track your seizures daily using an app.
Raleigh, North CarolinaAges 18–75 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Raleigh, North CarolinaAges 12 years+ - NCT07110454Recruiting
Long-term follow-up study for epilepsy monitoring implant
This study follows people who previously enrolled in the DETECT study and had a Minder device implanted to monitor brain activity. The goal is to see how the device performs over a longer period of time.
Durham, North CarolinaAges 18–75 - NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Durham, North CarolinaAges 18–75 - NCT06545643Recruiting
Sleep-sensitive seizure risk test with wearable EEG
This study uses a comfortable headband to track your sleep and brain activity. It may help better understand when seizures are likely to happen.
Durham, North CarolinaAges 18 years+ - NCT04715646RecruitingPhase 3
Brivaracetam study for children with hard-to-control seizures
This trial looks at how safe brivaracetam is and how well it can be used in children and teens with certain types of epilepsy that are not well controlled. It may help families who are dealing with frequent focal seizures despite taking seizure medicines.
Durham, North CarolinaAges 1 month+ - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Durham, North CarolinaAges 18–75 - NCT06138808Enrolling by invitation
5-sense score validation for epilepsy surgery
This study is for people with epilepsy who are being considered for brain surgery but cannot have a direct surgical approach. It tests a new scoring method (5-SENSE) that uses non-invasive tests like MRI and EEG to see if it can help doctors make better surgery decisions.
Durham, North CarolinaAges 15 years+ - NCT07271966Recruiting
Vitamin B6 for Keppra side effects in brain tumor patients
This trial tests whether vitamin B6 can help reduce mood and behavior side effects of levetiracetam (Keppra) in people with brain tumors and seizures. If you're taking Keppra and feeling down or distressed, this study might offer a way to feel better.
Durham, North CarolinaAges 18 years+ - NCT06422923RecruitingPhase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes
This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.
Durham, North CarolinaAges 18–75 - NCT07605858Recruiting
Epilepsy, Sleep, and Brain Activity Study
This study examines how seizures affect sleep quality and dreams in people with hard-to-treat focal epilepsy. Researchers will use specialized brain electrodes to understand these connections during sleep, which may help improve treatment in the future.
Durham, North CarolinaAges 18–55 - NCT06262594RecruitingPhase 3
Testing a sleep medicine for epilepsy-related insomnia
This study tests a new sleep medicine called lemborexant for people with epilepsy whose seizures happen during sleep and who also have trouble sleeping. The goal is to see if the medicine can help you sleep better without making your seizures worse.
Durham, North CarolinaAges 18 years+ - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Chapel Hill, North CarolinaAges 1 day–6 months - NCT06443463Enrolling by invitationPhase 2
Long-term safety of BHV-7000 in epilepsy
This study checks the long-term safety of BHV-7000 for people who already completed an earlier trial with this drug. You keep taking the same medicine while doctors watch for any side effects over time.
Chapel Hill, North CarolinaAges 18–75 - NCT06252532Enrolling by invitation
Brain wave study for epilepsy with electrodes
This research study looks at how certain brain waves (called theta oscillations) help you focus and prioritize information. If you have epilepsy that hasn't been controlled with medicines and you already have brain electrodes in place for your epilepsy monitoring, you may be able to join this study to help scientists understand the role of these brain signals.
Chapel Hill, North CarolinaAges 18–80
Hear when a new Epilepsy trial opens near Raleigh–Durham, NC
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Epilepsy trials in other cities
Where these studies are running near Raleigh–Durham
Institutions with a site for the recruiting epilepsy studies listed above.
- Duke University · 4 studies
- Duke University Medical Center · 4 studies
- University of North Carolina at Chapel Hill · 3 studies
- Duke University Health System · 2 studies
- Ep0156 237
- Meridian Clinical Research, LLC
- Velocity Clinical Research
What taking part in a epilepsy study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting epilepsy studies in North Carolina.
Common questions
- Are there epilepsy clinical trials near Raleigh–Durham?
- Yes. We're currently tracking 15 recruiting epilepsy studies with a site near Raleigh–Durham, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a epilepsy study near Raleigh–Durham?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Raleigh–Durham to take part?
- Not necessarily. These studies have a site near Raleigh–Durham, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New epilepsy studies open near Raleigh–Durham regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.