Clinical trials · Houston, TX
Epilepsy clinical trials in Houston
We’re tracking 25 recruiting epilepsy studies with a site in or near Houston — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Houston
- NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Houston, TexasAges 18–75 - NCT05989893Recruiting
Mapping human thinking during brain surgery
This study maps how thinking works in people with epilepsy or brain lesions near important brain areas. It involves testing during brain surgery procedures to help researchers understand healthy brain function.
Houston, TexasAges 18–75 - NCT05608408Recruiting
Preserving Memory in People With Epilepsy Using Brain Stimulation
This study tests a type of brain stimulation in people with epilepsy to see if it can help preserve memory. Researchers will compare memory and brain effects over time to understand whether stimulation changes memory outcomes.
Houston, TexasAges 18–65 - NCT05871372Recruiting
Study brain circuits behind mood using brain monitoring
This study looks at how brain networks relate to mood and depression by recording brain activity during specific procedures. You may be able to join if you’re already having brain monitoring for epilepsy or are part of a depression deep brain stimulation program.
Houston, TexasAges 21–70 - NCT05981755Recruiting
Breathing rescue to prevent SUDEP in epilepsy
This trial tests a breathing rescue device to prevent SUDEP (sudden unexpected death in epilepsy) in people with hard-to-control focal epilepsy who are staying in the hospital for invasive brain monitoring.
Houston, TexasAges 18 years+ - NCT06555965Recruiting
STXBP1 and SYNGAP1 natural history study
This study follows people with STXBP1 or SYNGAP1 gene changes over time to learn more about how these conditions affect the body and mind. It does not test a treatment but helps researchers understand the natural course of the disorder.
Houston, TexasAges Any age - NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Houston, TexasAges 18–70 - NCT06443463Enrolling by invitationPhase 2
Long-term safety of BHV-7000 in epilepsy
This study checks the long-term safety of BHV-7000 for people who already completed an earlier trial with this drug. You keep taking the same medicine while doctors watch for any side effects over time.
Houston, TexasAges 18–75 - NCT06934356Recruiting
Awareness and brain arousal study
This study looks at how your brain becomes aware of things—like sounds and images—by measuring pupil size and brain activity. Healthy people may have an MRI; epilepsy patients with special brain electrodes already implanted can also join a part of the study.
Houston, TexasAges 13 years+ - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Houston, TexasAges 1 day–6 months - NCT07287163Enrolling by invitationPhase 3
Long-term study of vormatrigine for epilepsy
This trial is for adults with epilepsy who have already taken vormatrigine in a previous study or through a special access program. It aims to collect ongoing safety and effectiveness information.
Houston, TexasAges 18–85 - NCT06132893RecruitingPhase 2/Phase 3
Testing BHV-7000 for hard-to-control focal seizures in adults
This study tests a new medicine called BHV-7000 for adults whose focal seizures (starting in one part of the brain) are not controlled by current treatments. The goal is to see if it can reduce seizures safely.
Houston, TexasAges 18–75 - NCT07509177Recruiting
Infrared light therapy for stress in epilepsy
This trial tests if infrared light therapy can help reduce stress in people with epilepsy. You would wear a ring to track your sleep and activity, and attend 45 light therapy sessions over several months.
Houston, TexasAges 18 years+ - NCT06422923RecruitingPhase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes
This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.
Houston, TexasAges 18–75 - NCT06695767Recruiting
Behavioral therapy for epilepsy and depression in veterans
This trial tests a special therapy program for veterans who have both epilepsy and major depression. It uses talk therapy and text message support to help improve mood and seizure control.
Houston, TexasAges 18 years+ - NCT07594119RecruitingPhase 3
Testing RAP-219 to reduce seizures in focal epilepsy
This study tests a new medication called RAP-219 to see if it can reduce seizure frequency in adults with focal epilepsy (seizures starting in one area of the brain). You'll take the medication alongside your current seizure drugs and track your seizures daily using an app.
Houston, TexasAges 18–75 - NCT04677751Recruiting
Testing acupuncture effects in people with an implanted seizure device
This study looks at how adding acupuncture may change seizure activity in people who already have an implanted RNS seizure monitor and stimulator. You might benefit by learning whether acupuncture helps with seizure patterns without changing your usual treatments.
Houston, TexasAges 15–60 - NCT05418894Recruiting
Study brain signals and improve treatment-resistant depression
This trial studies how brain activity relates to feelings and depression, using brain electrodes to measure signals. It’s meant for people with long-lasting, treatment-resistant major depression who may need stimulation while continuing psychiatric care.
Houston, TexasAges 22–70 - NCT03953768Recruiting
Testing a new vagus nerve stimulator for gut and immune health
This study looks at what happens to your immune system and stomach/gut function after getting a vagus nerve stimulator (VNS) for the first time for epilepsy. It may help doctors understand whether the device benefits more than seizures.
Houston, TexasAges birth–60 years - NCT02846272Recruiting
Brain scans in children with hard-to-treat epilepsy
This study uses special brain imaging to look at how brain cells and networks work in children with intractable, or hard-to-treat, epilepsy. The goal is to connect the scan findings with what’s found in clinical evaluation to better understand the condition.
Houston, TexasAges birth–18 years - NCT05600738Recruiting
Deep brain stimulation to treat epilepsy
This trial studies how adding or using deep brain stimulation devices affects people with epilepsy. It may help researchers understand which outcomes improve when these implanted devices are used.
Houston, TexasAges 18 years+ - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Houston, TexasAges 18–75 - NCT05283811Recruiting
Brain recording during epilepsy care, while doing a memory task
This study listens to brain activity in people with epilepsy who already need electrodes placed inside the brain. Researchers want to understand how different parts of the brain respond while you complete simple thinking and memory-related tasks, which may help improve future treatments.
Houston, TexasAges 10–64 - NCT07051629RecruitingPhase 1
Testing a new epilepsy medicine for safety in healthy people and patients
This study tests a new medicine called SIF001 for safety. It first gives the medicine to healthy volunteers, and then to people with epilepsy who have seizures even while on their current medicines. The goal is to find a safe dose.
Cypress, TexasAges 18–70
Hear when a new Epilepsy trial opens near Houston, TX
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Epilepsy trials in other cities
Where these studies are running near Houston
Institutions with a site for the recruiting epilepsy studies listed above.
- The University of Texas Health Science Center at Houston · 12 studies
- Baylor College of Medicine · 5 studies
- Michael E. DeBakey VA Medical Center · 3 studies
- Clinical Research Solutions LLC · 2 studies
- Horizon Clinical Research Center · 2 studies
- Texas Children's Hospital · 2 studies
- Houston Neuroscience Brain Center
- Research Site
What taking part in a epilepsy study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting epilepsy studies in Texas.
Common questions
- Are there epilepsy clinical trials near Houston?
- Yes. We're currently tracking 25 recruiting epilepsy studies with a site near Houston, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a epilepsy study near Houston?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Houston to take part?
- Not necessarily. These studies have a site near Houston, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New epilepsy studies open near Houston regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.