Clinical trials · Pennsylvania
Epilepsy clinical trials in Pennsylvania
We’re tracking 18 recruiting epilepsy studies with a site in Pennsylvania — including Early Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT07110454Recruiting
Long-term follow-up study for epilepsy monitoring implant
This study follows people who previously enrolled in the DETECT study and had a Minder device implanted to monitor brain activity. The goal is to see how the device performs over a longer period of time.
Philadelphia, PennsylvaniaAges 18–75 - NCT04649008RecruitingEarly Phase 1
MRI and brain electrodes to map epilepsy areas
This early study looks at how MRI scans and implanted brain electrodes (intracranial EEG) can pinpoint where seizures start, especially in the temporal (side) lobe. It may help doctors better localize seizure sources for people whose seizures don’t respond well to medications.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Philadelphia, PennsylvaniaAges 18–75 - NCT06265103Recruiting
Epilepsy learning healthcare system registry
This is a registry study that collects information from people being treated for epilepsy at participating healthcare centers. The goal is to improve care by learning from real-world patient data.
Philadelphia, PennsylvaniaAges Any age - NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Philadelphia, PennsylvaniaAges 18–75 - NCT07219407RecruitingPhase 2
Long-term safety study of RAP-219 for focal seizures
This study tests the long-term safety and effectiveness of RAP-219, an investigative medication for focal epilepsy. It is for people who already completed an earlier study of RAP-219, have a type of epilepsy that doesn't respond to standard medicines, and use a surgically implanted brain device (RNS system) to help manage seizures.
Philadelphia, PennsylvaniaAges 18–70 - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Philadelphia, PennsylvaniaAges 18–75 - NCT07287163Enrolling by invitationPhase 3
Long-term study of vormatrigine for epilepsy
This trial is for adults with epilepsy who have already taken vormatrigine in a previous study or through a special access program. It aims to collect ongoing safety and effectiveness information.
Philadelphia, PennsylvaniaAges 18–85 - NCT06063850RecruitingPhase 1/Phase 2
Gene therapy for adults with hard-to-control epilepsy
This trial tests a one-time gene therapy (AMT-260) for adults whose seizures start in one area of the brain (the temporal lobe) and aren't controlled by medication. The goal is to see if it's safe and reduces seizure frequency.
Philadelphia, PennsylvaniaAges 18–75 - NCT06132893RecruitingPhase 2/Phase 3
Testing BHV-7000 for hard-to-control focal seizures in adults
This study tests a new medicine called BHV-7000 for adults whose focal seizures (starting in one part of the brain) are not controlled by current treatments. The goal is to see if it can reduce seizures safely.
Pittsburgh, PennsylvaniaAges 18–75 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Philadelphia, PennsylvaniaAges 12 years+ - NCT01238250Recruiting
Online autism genetics study for families with certain genetic changes
This study asks people with specific genetic changes linked to autism and their family members to complete online tasks and questionnaires. It may help researchers better understand how these genetic differences relate to autism traits.
Lewisburg, PennsylvaniaAges Any age - NCT07713706Enrolling by invitation
Brain activity study for speech production
This study looks at how the brain stops speech, using electrical recordings taken during your already-planned epilepsy monitoring. It may help understand speech control.
Pittsburgh, PennsylvaniaAges 8–26 - NCT05450978Recruiting
Study drug levels in epilepsy meds during pregnancy and breastfeeding
This study measures how much epilepsy medicine (lamotrigine, levetiracetam, or oxcarbazepine) your body absorbs during pregnancy and breastfeeding. It may help doctors better understand dosing and safety during these times.
Pittsburgh, PennsylvaniaAges 18–45 - NCT06555965Recruiting
STXBP1 and SYNGAP1 natural history study
This study follows people with STXBP1 or SYNGAP1 gene changes over time to learn more about how these conditions affect the body and mind. It does not test a treatment but helps researchers understand the natural course of the disorder.
Philadelphia, PennsylvaniaAges Any age - NCT06934356Recruiting
Awareness and brain arousal study
This study looks at how your brain becomes aware of things—like sounds and images—by measuring pupil size and brain activity. Healthy people may have an MRI; epilepsy patients with special brain electrodes already implanted can also join a part of the study.
Pittsburgh, PennsylvaniaAges 13 years+ - NCT06443463Enrolling by invitationPhase 2
Long-term safety of BHV-7000 in epilepsy
This study checks the long-term safety of BHV-7000 for people who already completed an earlier trial with this drug. You keep taking the same medicine while doctors watch for any side effects over time.
Pittsburgh, PennsylvaniaAges 18–75 - NCT06138808Enrolling by invitation
5-sense score validation for epilepsy surgery
This study is for people with epilepsy who are being considered for brain surgery but cannot have a direct surgical approach. It tests a new scoring method (5-SENSE) that uses non-invasive tests like MRI and EEG to see if it can help doctors make better surgery decisions.
Pittsburgh, PennsylvaniaAges 15 years+
Epilepsy trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting epilepsy studies listed above.
- University of Pennsylvania · 8 studies
- Thomas Jefferson University Hospital · 5 studies
- University of Pittsburgh Medical Center · 3 studies
- Allegheny Health Network · 2 studies
- Children's Hospital of Philadelphia · 2 studies
- Geisinger Health System
- Penn State Hershey
- Praxis Research Site
What taking part in a epilepsy study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Epilepsy trials in other states
Common questions
- Are there epilepsy clinical trials in Pennsylvania?
- Yes. We're currently tracking 18 recruiting epilepsy studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a epilepsy study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New epilepsy studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.