Clinical trials · California
Epilepsy clinical trials in California
We’re tracking 38 recruiting epilepsy studies with a site in California — including Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07680842Recruiting
Non-invasive ultrasound for drug-resistant epilepsy
This study tests a non-invasive focused ultrasound treatment for people with epilepsy that doesn't respond to medications. The goal is to see if this gentle ultrasound can reduce seizures without surgery.
San Francisco, CaliforniaAges 21–65 - NCT07580183Recruiting
Memory and Brain Function in Epilepsy Surgery
This study examines how the brain recognizes spatial scenes (like rooms or landscapes) in people with epilepsy who may have surgery. Researchers want to understand memory patterns before and after surgery to help predict outcomes.
Sacramento, CaliforniaAges 18–55 - NCT06608966Recruiting
Epilepsy Journey: Helping Teens Manage Daily Challenges
This study tests a program called Epilepsy Journey to help teenagers with epilepsy improve skills like planning, organizing, and staying on task. It is designed for teens who struggle with these thinking skills and live at home with a caregiver.
Orange, CaliforniaAges 13–17 - NCT07110454Recruiting
Long-term follow-up study for epilepsy monitoring implant
This study follows people who previously enrolled in the DETECT study and had a Minder device implanted to monitor brain activity. The goal is to see how the device performs over a longer period of time.
Palo Alto, CaliforniaAges 18–75 - NCT06265103Recruiting
Epilepsy learning healthcare system registry
This is a registry study that collects information from people being treated for epilepsy at participating healthcare centers. The goal is to improve care by learning from real-world patient data.
Los Angeles, CaliforniaAges Any age - NCT07110337Recruiting
Diagnosing epilepsy to help guide treatment
This trial tests a new device to help diagnose epilepsy in people whose previous EEG brain monitoring did not give clear answers. If you have drug-resistant epilepsy with at least one seizure a month on average, this study may help find better treatment options.
Irvine, CaliforniaAges 18–75 - NCT06388707RecruitingPhase 1/Phase 2
Ultrasound therapy for drug-resistant temporal lobe epilepsy
This study tests if a new, non-invasive ultrasound treatment can safely reduce seizures in people whose seizures start in the temporal lobe and have not been controlled by at least two anti-epileptic drugs. The ultrasound is delivered through the scalp to gently stimulate the brain area where the seizures begin.
Palo Alto, CaliforniaAges 18 years+ - NCT05135091RecruitingPhase 3
Cell therapy trial for hard-to-control one-sided temporal lobe epilepsy
This Phase 3 study tests a neural cell therapy (NRTX-1001) for adults whose seizures come from one side of the hippocampus and have not improved with standard seizure medicines. The goal is to reduce seizure frequency and improve seizure control where other treatments have not worked.
Los Angeles, CaliforniaAges 18–75 - NCT01403402Recruiting
Study of congenital muscle disease patients and their families
This trial collects health information from patients with certain inherited (genetic) muscle diseases and from their families. It may help researchers better understand the disease and improve care by learning what symptoms and treatments patients experience over time.
Lakewood, CaliforniaAges Any age - NCT07723963RecruitingPhase 2/Phase 3
Study of JZP926 for juvenile myoclonic epilepsy
This study tests an investigational drug called JZP926 (a type of cannabinoid) to see if it can reduce the number of days with myoclonic seizures in people with juvenile myoclonic epilepsy. If you have this condition and are at least 10 years old, you might be able to join.
Sacramento, CaliforniaAges 10 years+ - NCT07563881RecruitingPhase 3
Testing RAP-219 for Focal Seizure Control in Adults
This study tests whether a new medication called RAP-219 can help adults with focal seizures (seizures that start in one area of the brain) control their seizures better. You would take this medication alongside your current seizure drugs for about 12 weeks.
Palmdale, CaliforniaAges 18–75 - NCT06952764Enrolling by invitation
ECLIPSE: Tracking epilepsy cycles to predict seizures
This trial tests if tracking your brain activity with an implanted device can help predict when seizures might happen. It is for adults who have seizures despite medication and already have the RNS System implanted.
San Francisco, CaliforniaAges 18 years+ - NCT06716866Enrolling by invitation
Electric field stimulation for epilepsy
This trial tests a new type of brain stimulation using electric fields to treat epilepsy, specifically for people who are already having invasive EEG monitoring as part of their care.
Sacramento, CaliforniaAges 18 years+ - NCT06422923RecruitingPhase 1/Phase 2
Cell therapy for hard-to-treat epilepsy starting in both temporal lobes
This trial tests a new cell therapy (NRTX-1001) for people with epilepsy that starts in both sides of the brain's temporal lobes and doesn't get better with medication. It aims to reduce or stop seizures.
Los Angeles, CaliforniaAges 18–75 - NCT06063850RecruitingPhase 1/Phase 2
Gene therapy for adults with hard-to-control epilepsy
This trial tests a one-time gene therapy (AMT-260) for adults whose seizures start in one area of the brain (the temporal lobe) and aren't controlled by medication. The goal is to see if it's safe and reduces seizure frequency.
Palo Alto, CaliforniaAges 18–75 - NCT05794295Recruiting
Sleep study in people with focal epilepsy
This trial studies how sleep patterns relate to thinking and memory in people with focal epilepsy. It may help researchers understand what sleep changes could support brain function in epilepsy.
Sacramento, CaliforniaAges 18–40 - NCT05718817Enrolling by invitationPhase 3
Long-term study of XEN1101 for people with epilepsy
This study gives XEN1101 in an open-label way (everyone knows they’re getting the drug) to people who finished earlier epilepsy studies. It aims to see how the treatment continues to work and whether it’s safe over the long term.
Los Angeles, CaliforniaAges 12 years+ - NCT05283811Recruiting
Brain recording during epilepsy care, while doing a memory task
This study listens to brain activity in people with epilepsy who already need electrodes placed inside the brain. Researchers want to understand how different parts of the brain respond while you complete simple thinking and memory-related tasks, which may help improve future treatments.
Los Angeles, CaliforniaAges 10–64 - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Los Angeles, CaliforniaAges 1 day–6 months - NCT02151175Enrolling by invitation
Focused ultrasound to treat medication-resistant temporal lobe seizures
This trial tests a low-intensity focused ultrasound treatment aimed at reducing seizures caused by problems in one side of the hippocampus (a brain area involved in memory and seizures). It’s for people whose seizures have not responded to several seizure medicines and who have been offered a specific type of surgery.
Los Angeles, CaliforniaAges 18–60 - NCT07822178Enrolling by invitation
How the brain understands faces during epilepsy monitoring
This study looks at how the brain understands faces by recording brain activity while you look at pictures. It uses the electrodes already placed in your brain during epilepsy monitoring, so no extra procedures are needed.
Los Angeles, CaliforniaAges 18 years+ - NCT07663578Recruiting
Brain stimulation study for epilepsy patients and healthy volunteers
This study tests a new non-invasive brain stimulation method called TIEFS. It uses safe electric fields to see how it affects thinking and brain waves. You may join if you are having brain surgery for epilepsy or are a healthy adult.
Sacramento, CaliforniaAges 18–65 - NCT07454785Enrolling by invitation
How the brain learns new patterns
This study looks at how the brain learns and uses patterns. If you have epilepsy that requires brain monitoring, you may be able to join and help researchers understand memory and thinking.
Los Angeles, CaliforniaAges 18 years+ - NCT07226908Enrolling by invitation
Brain electrode study for epilepsy and memory
This study places electrodes in the brain to learn how seizures spread and how memory works. It may help people with temporal lobe epilepsy understand their condition better and improve future treatments.
Stanford, CaliforniaAges 18–65
Epilepsy trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting epilepsy studies listed above.
- Stanford University · 7 studies
- University of California, San Francisco · 4 studies
- University of California, Davis · 3 studies
- University of California, Irvine · 3 studies
- Cedars-Sinai Medical Center · 2 studies
- UC Davis Health · 2 studies
- University of California San Diego · 2 studies
- University of California, Los Angeles · 2 studies
What taking part in a epilepsy study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Epilepsy trials in other states
Common questions
- Are there epilepsy clinical trials in California?
- Yes. We're currently tracking 38 recruiting epilepsy studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a epilepsy study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a epilepsy trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New epilepsy studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.