Clinical trials
Focal Epilepsy clinical trials
Below are recruiting focal epilepsy clinical trials, each written for real people, not researchers. We’re tracking 47 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06205160Recruiting
Flexible brain electrodes for epilepsy surgery
This trial is testing new flexible brain electrodes during epilepsy surgery. These electrodes may help doctors map brain activity better than standard rigid ones. If you are having surgery for epilepsy caused by a brain lesion, you might be able to join.
UtrechtAges 18 years+ - NCT06492720Recruiting
Testing focused ultrasound for drug-resistant epilepsy
This study tests a new device called NaviFUS that uses focused sound waves to gently stimulate a small area of the brain. It is for people whose seizures start in one part of the brain and are not fully controlled by seizure medicines.
TaipeiAges 18–65 - NCT06248333Recruiting
Deep brain stimulation for focal motor epilepsy
This trial tests whether deep brain stimulation of a small area in the brain can help reduce seizures that start in the motor part of the brain and do not respond to medication. It may be an option for people who cannot have surgery or whose surgery did not help enough.
Beijing, Beijing MunicipalityAges 14–65 - NCT07095933RecruitingEarly Phase 1
Everolimus for hard-to-control focal epilepsy
This study tests whether the medicine everolimus (taken as a pill) can safely reduce seizures in adults with focal epilepsy that hasn't been controlled by other treatments. You would continue your current seizure medicines and add everolimus.
Beijing, Beijing MunicipalityAges 18–60 - NCT03268824Recruiting
Brain imaging study in drug-resistant focal epilepsy
This study uses MRI brain scans to see how “epileptic discharges” may affect brain connections in the developing brain. It also scans comparison participants without drug-resistant focal epilepsy to help researchers understand what is different.
ParisAges 1.5 years–16 years - NCT07012148Recruiting
Seizure forecasting with EEG and wearables for epilepsy
This study tests a wearable device that records brain waves to help predict and track seizures in people with temporal lobe epilepsy. It may help you better understand your seizure patterns and reduce uncertainty.
Rochester, MinnesotaAges 18–75 - NCT06022055Recruiting
studying brain tissue from epilepsy surgery
This study collects brain tissue from people with epilepsy that is not controlled by medication, during their planned surgery. Researchers will study the tissue to better understand epilepsy and improve treatments.
ParisAges 18 years+ - NCT06719791RecruitingEarly Phase 1
Sirolimus for hard-to-treat focal epilepsy
This trial tests if the drug sirolimus can help people with focal seizures (starting in one part of the brain) that don't improve with at least two other medications. It aims to reduce seizure frequency in adults aged 18 to 60.
BeijingAges 18–60 - NCT07656857Recruiting
Flexible brain sensor study for epilepsy surgery
This trial tests a new flexible brain sensor to help guide surgery for people with drug-resistant focal epilepsy. It aims to find exactly where seizures start so surgeons can remove that area safely.
Beijing, Beijing MunicipalityAges 3–60 - NCT07287163Enrolling by invitationPhase 3
Long-term study of vormatrigine for epilepsy
This trial is for adults with epilepsy who have already taken vormatrigine in a previous study or through a special access program. It aims to collect ongoing safety and effectiveness information.
Miami, FloridaAges 18–85 - NCT02107989Recruiting
MRI and brain scans before epilepsy surgery
This study collects noninvasive brain scan data (mainly MRI, sometimes MEG) from people being evaluated for focal epilepsy surgery, and from healthy volunteers. It aims to build reference “normal” brain images and improve how doctors plan and interpret epilepsy surgery evaluations.
Bethesda, MarylandAges 8–120 - NCT04653012Recruiting
Testing brain-activity recordings in people with drug-resistant epilepsy
This study looks at brain activity using electrodes placed inside the brain in people with focal, drug-resistant epilepsy before surgery. It may help doctors better map where seizures start and improve planning for treatment.
ParisAges 18 years+ - NCT05981755Recruiting
Breathing rescue to prevent SUDEP in epilepsy
This trial tests a breathing rescue device to prevent SUDEP (sudden unexpected death in epilepsy) in people with hard-to-control focal epilepsy who are staying in the hospital for invasive brain monitoring.
Houston, TexasAges 18 years+ - NCT06453759Recruiting
Brain recordings during SEEG in children
This study takes extra recordings from the brain during a routine SEEG procedure in children with epilepsy to learn more about how the brain works. It may help improve future epilepsy surgeries.
LondonAges 2–20 - NCT06716801Recruiting
How cenobamate works as early add-on treatment for epilepsy
This study looks at how well cenobamate works when added to other seizure medications for adults with focal epilepsy. It uses real-world data from medical records to see how people respond to treatment.
Paris, FranceAges 18 years+ - NCT07605858Recruiting
Epilepsy, Sleep, and Brain Activity Study
This study examines how seizures affect sleep quality and dreams in people with hard-to-treat focal epilepsy. Researchers will use specialized brain electrodes to understand these connections during sleep, which may help improve treatment in the future.
Durham, North CarolinaAges 18–55 - NCT06443463Enrolling by invitationPhase 2
Long-term safety of BHV-7000 in epilepsy
This study checks the long-term safety of BHV-7000 for people who already completed an earlier trial with this drug. You keep taking the same medicine while doctors watch for any side effects over time.
Birmingham, AlabamaAges 18–75 - NCT06466681Recruiting
Attention changes after a seizure in epilepsy
This study looks at how attention and concentration change right after a seizure in people with epilepsy. It uses a short hospital stay to track these changes, which may help improve understanding and future treatment.
LilleAges 18–80 - NCT06922175Recruiting
Study on cenobamate and healthcare use in epilepsy
This study looks at how cenobamate (a medication for seizures) affects healthcare use, like hospital visits or emergency room trips, in people with epilepsy whose seizures were not well-controlled by 2 to 5 other medicines. It is a real-world study, meaning it uses medical records to understand the impact.
Freiburg im Breisgau, GermanyAges 18 years+ - NCT06391294Enrolling by invitation
Brain stimulation study for language mapping during awake surgery
This study uses gentle electrical stimulation on the brain during awake surgery to understand how language works. It's for people having brain tumor removal or epilepsy monitoring who can speak English and do not have serious speech or thinking problems.
Chicago, IllinoisAges 18–80 - NCT06908356RecruitingPhase 2
Testing PRAX-628 for focal or tonic-clonic seizures
This study tests an experimental pill called PRAX-628 for adults whose seizures are not fully controlled by current medications. It aims to see if the drug is safe and effective at reducing seizures.
Phoenix, ArizonaAges 18–75 - NCT06388161Recruiting
Autoantibody study in new focal seizures
This research study looks for specific immune system markers (autoantibodies) in the blood and spinal fluid of people who have recently started having focal seizures (seizures that start in one part of the brain) with no known cause. Finding these markers could help doctors understand why the seizures started.
Hangzhou, ZhejiangAges 14–100 - NCT06065852Recruiting
National registry for rare kidney diseases
This study creates a registry to collect health information from people with rare kidney diseases. It aims to improve understanding and future treatments by tracking patient experiences.
Bristol, South WestAges Any age
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Common questions
- Are there clinical trials for focal epilepsy?
- Yes. Clin2 currently lists 47 recruiting focal epilepsy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a focal epilepsy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a focal epilepsy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.