Clinical trials
Focused Ultrasound clinical trials
Below are recruiting focused ultrasound clinical trials, each written for real people, not researchers. We’re tracking 104 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06185972RecruitingPhase 2
MRI-guided ultrasound radiation for breast and chest cancer
This trial tests a new way to give radiation therapy using MRI imaging and ultrasound to make the radiation more targeted and potentially safer. If you have chest-wall or breast cancer and are already scheduled for radiation, this approach might offer a more precise treatment option.
Toronto, OntarioAges 18 years+ - NCT07166289Recruiting
Ultrasound treatment for tough depression
This study uses focused ultrasound to stimulate brain circuits in people with treatment-resistant depression. It aims to see if this can help when other treatments haven't worked.
Tulsa, OklahomaAges 18–65 - NCT06633601RecruitingPhase 1
Ultrasound and microbubbles with radiation for breast cancer
This trial tests a new way to combine radiation therapy with ultrasound and tiny bubbles to treat breast cancer that has spread to the chest wall or is advanced. It aims to make radiation more effective and safer.
Toronto, OntarioAges 18 years+ - NCT06939348Recruiting
Ultrasound therapy for patients with consciousness disorders
This trial tests whether ultrasound stimulation can help people with disorders of consciousness, like coma or a minimally conscious state. It aims to improve brain function and recovery for patients who have been injured for over a month.
Los Angeles, CaliforniaAges 18–79 - NCT07668882Recruiting
Ultrasound brain stimulation for persistent stuttering
This study tests whether low-intensity focused ultrasound can change brain activity linked to stuttering. It may help people who have not had stuttering treatment in the past year.
Ann Arbor, MichiganAges 18–65 - NCT07757490Recruiting
Sonablate HIFU registry for prostate cancer and BPH
This study is a registry that collects information from men who have had Sonablate HIFU treatment for prostate cancer or enlarged prostate (BPH). It will help doctors learn more about how well this treatment works in real life.
Indianapolis, IndianaAges 18 years+ - NCT06487013Recruiting
Focused ultrasound for painful bone metastases
This trial tests a focused ultrasound treatment called ArcBlate to relieve pain from bone cancer that has spread. It is for people who have moderate to severe pain despite cancer therapy and have chosen not to have surgery or radiation for that pain.
New Taipei CityAges 18 years+ - NCT06435663Recruiting
ultramicro-flow technique for focused ultrasound treatment of uterine tumors
This study tests a new imaging tool (ultramicro-flow technique) to help doctors treat uterine fibroids or adenomyosis with focused ultrasound without surgery. The goal is to make the treatment safer and more accurate, especially for tumors deep inside the uterus.
Yiwu, ZhejiangAges 18–50 - NCT07287605Recruiting
Virtual reality for mood during focused ultrasound for essential tremor
This study tests if using virtual reality can improve your mood while you undergo a focused ultrasound procedure for essential tremor. If you are already scheduled for this treatment, you may be able to join.
North York, OntarioAges 18 years+ - NCT07690514Recruiting
Ultrasound treatment for cervical dystonia
This study tests a new type of ultrasound treatment for cervical dystonia (neck muscle spasms). It uses focused sound waves to target the brain areas causing the condition, and aims to see if it can reduce symptoms without surgery.
Toronto, OntarioAges 18–90 - NCT07728994RecruitingPhase 2
Focused ultrasound for OCD treatment study
This trial tests if focused ultrasound can help treat OCD. If you join, you'll wear a special device during sessions and have an MRI scan.
San Francisco, CaliforniaAges 22–80 - NCT07558148Recruiting
Low-intensity ultrasound for OCD symptom detection and relief
This study tests whether a wearable sleeve device using ultrasound can detect compulsive hand and arm movements in people with OCD, and whether the device can help reduce symptoms. You'll undergo MRI brain scans and wear the device during treatment sessions.
Philadelphia, PennsylvaniaAges 18–60 - NCT05317858RecruitingPhase 3
Open the brain’s blood barrier to treat lung cancer brain spots
This trial tests whether using focused ultrasound to temporarily open the brain’s blood barrier—plus standard immune therapy—can better treat non-small cell lung cancer (NSCLC) that has spread to the brain. It aims to help medicines reach the brain tumor spots more effectively, while still using the usual lung cancer treatment.
Phoenix, ArizonaAges 18–100 - NCT06964906RecruitingPhase 2
HIFU, immunotherapy, and chemo for ER+ HER2- breast cancer
This trial tests a combination of high-intensity focused ultrasound (HIFU, a non-invasive treatment that uses sound waves to heat and destroy tumor tissue) with the immunotherapy drug toripalimab and standard chemotherapy before surgery for women with a specific type of breast cancer (ER-positive, HER2-negative). The goal is to see if this approach can improve treatment outcomes for women with high-risk disease.
Hangzhou, ZhejiangAges 18–75 - NCT04557891Recruiting
Low-intensity ultrasound for generalized anxiety disorder
This trial tests a non-drug brain treatment using low-intensity focused ultrasound to reduce symptoms of generalized anxiety disorder (GAD). It may help if your anxiety has been moderate to severe and you’ve already tried standard medications without enough relief.
Los Angeles, CaliforniaAges 18–65 - NCT04803773Recruiting
MRI-guided ultrasound to treat painful bone tumors
This feasibility study tests an MRI-guided focused ultrasound treatment for certain painful bone tumors, including bone metastases and osteoid osteoma. The goal is to see if the treatment can be safely delivered to the right spot and help with pain.
StrasbourgAges 18 years+ - NCT07226648Recruiting
Ultrasound treatment for fibromyalgia pain
This trial tests a new ultrasound device that targets a pain-related brain area to relieve fibromyalgia. It is for people who have not found enough relief from at least two medications and have also tried other therapies like exercise or CBT.
Ann Arbor, MichiganAges 22 years+ - NCT05111964Recruiting
Ultrasound treatment for soft tissue sarcoma tumors
This trial tests a non-surgical ultrasound treatment (HIFU) that targets the tumor from the outside of the body. It may help by shrinking or controlling certain types of soft tissue sarcoma or desmoid tumors when they are hard to remove surgically or when surgery/chemo/radiation is not a good option.
Oxford, OxfordshireAges 18 years+ - NCT05219695Recruiting
Imaging and controlled heat treatment for breast tumors
This study uses special ultrasound-like imaging to guide a controlled heat treatment during planned surgery for certain breast tumors. It may help doctors better see and treat tumor tissue while you already have surgery scheduled.
New York, New YorkAges 18 years+ - NCT05291507RecruitingEarly Phase 1
MRI-guided focused ultrasound for breast cancer during surgery
This early study tests whether a device that uses focused ultrasound (guided by MRI) can be safely used during surgery for women with invasive breast cancer. It mainly looks at feasibility—whether the treatment can be delivered as planned and is safe.
Salt Lake City, UtahAges 18 years+ - NCT05500118Recruiting
Decision help tool for symptom-free fibroids treated with HIFU
This study is testing a decision-making tool to help doctors choose the best care for women with small fibroids that cause no symptoms. It also looks at factors that may affect outcomes when using HIFU, a non-surgical treatment that heats tissue with focused ultrasound.
Shenzhen, GuangdongAges 18–55 - NCT05565443Recruiting
Ultrasound plus GCase treatment for Parkinson’s symptoms
This trial studies whether MR-guided focused ultrasound combined with an enzyme treatment called GCase can improve Parkinson’s disease. It includes people with specific Parkinson’s diagnosis and scan findings, and it may help those with certain genetic or imaging markers.
Toronto, OntarioAges 35–80 - NCT05762419RecruitingPhase 1
FUS and etoposide treatment for midline brain tumors
This early-phase study tests whether focusing ultrasound (FUS) plus etoposide can help treat children and teens with diffuse midline glioma that affects the brainstem (pons) and/or thalamus, especially with an H3K27M change. Participants must have cancer that is getting worse and be healthy enough to safely receive study treatment.
New York, New YorkAges 4–21 - NCT05784805Recruiting
Focused ultrasound treatment during EEG monitoring for ongoing seizures
This trial tests whether a focused ultrasound treatment can change brain electrical activity seen on an EEG in people with ongoing seizure emergencies. It may help doctors learn safer ways to modulate seizure activity when standard medicines are not fully stopping it.
New Haven, ConnecticutAges 19–85
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Common questions
- Are there clinical trials for focused ultrasound?
- Yes. Clin2 currently lists 104 recruiting focused ultrasound studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a focused ultrasound trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a focused ultrasound trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.