Clinical trials
Focused Ultrasound clinical trials
Below are recruiting focused ultrasound clinical trials, each written for real people, not researchers. We’re tracking 104 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05610852Recruiting
Surgery through the bladder opening versus focused ultrasound for prostate cancer
This trial compares two ways to treat early prostate cancer: a single small surgery through the bladder versus high-intensity focused ultrasound (HIFU). It aims to see which approach works better while keeping side effects and recovery acceptable.
Cleveland, OhioAges 19 years+ - NCT06453109Recruiting
Focused ultrasound for chronic back pain with opioid use
This study tests whether focused ultrasound (a non-invasive treatment using sound waves) can help people with chronic back pain who also have opioid use disorder and anxiety. It aims to find a better way to manage pain without relying on opioids.
Washington D.C., District of ColumbiaAges 18–75 - NCT07277309Recruiting
Recovery after brain injury using focused ultrasound
This study tests whether focused ultrasound can help people recover from a brain injury that has left them with a disorder of consciousness. The treatment involves a non-invasive technique that uses sound waves to stimulate brain activity.
Boston, MassachusettsAges 18–79 - NCT05620290RecruitingPhase 1
MR-guided ultrasound plus radiation to help skin cancer respond
This Phase 1 study tests a new way to make radiation work better using MRI-guided focused ultrasound. It focuses on improving treatment for malignant melanoma and other skin cancers, while checking safety and how patients experience treatment.
Toronto, OntarioAges 18 years+ - NCT06036199Recruiting
Focused ultrasound for movement problems in cerebral palsy
This trial tests if focused ultrasound can help reduce uncontrolled movements in children and young adults with cerebral palsy caused by a lack of oxygen at birth. It may offer an option for those whose current medications aren't working well enough.
Washington D.C., District of ColumbiaAges 8–22 - NCT06405074Recruiting
Ultrasound for Smoking Cessation in Veterans
This study tests if a gentle ultrasound aimed at a specific part of the brain (the insula) can help veterans who smoke tobacco reduce or quit smoking. The research is for veterans who smoke heavily and are motivated to think about quitting but are not currently in treatment.
Washington D.C., District of ColumbiaAges 18–75 - NCT06816511Enrolling by invitation
Focused ultrasound study for hard-to-treat OCD
This trial tests if a non-invasive ultrasound treatment can help people with obsessive-compulsive disorder (OCD) that hasn't improved with standard therapies. You must have had OCD for at least five years, have severe symptoms, and have tried multiple medications and cognitive-behavioral therapy without enough benefit.
TaipeiAges 18–65 - NCT07734623Recruiting
Ultrasound treatment for severe opioid or amphetamine use disorder
This trial tests a low-intensity focused ultrasound treatment for people with severe opioid or amphetamine use disorder. The ultrasound targets a part of the brain linked to addiction, and the goal is to see if it is safe and helpful.
TaipeiAges 20–50 - NCT06906211Recruiting
Ultrasound for chronic back pain in veterans
This trial tests if a gentle ultrasound treatment to a specific part of the brain can help veterans with chronic back pain. It aims to see if targeting the insula can reduce pain that spreads to other areas of the body.
Washington D.C., District of ColumbiaAges 21–75 - NCT04063514Enrolling by invitation
MRI-focused ultrasound study of blood-brain barrier in low-grade glioma
This study uses special imaging during routine MRI scans to check how well the blood-brain barrier lets substances pass in people with low-grade brain tumors. It may help researchers better measure and track treatment effects over time.
Santa Monica, CaliforniaAges 18 years+ - NCT07168850Recruiting
Focused Ultrasound for Dystonia of Arms or Legs
This study tests whether focused ultrasound, a noninvasive treatment that uses sound waves to target a small area in the brain, can improve limb dystonia that has not been helped by medications or Botox injections. It is a possible option for people whose dystonia affects their arms or legs and who are looking for another treatment without surgery.
Mestre, (Venice)Ages 18–80 - NCT07343986RecruitingPhase 1
Ultrasound and Immunotherapy for Newly Diagnosed Brain Cancer
This trial tests whether a special ultrasound (LIFU) can open the blood-brain barrier to help an immunotherapy drug (cetuximab) reach glioblastoma tumors better. It is for people with a specific type of glioblastoma that has not been treated yet and that has a certain protein called EGFR.
Charlottesville, VirginiaAges 18–70 - NCT07172295Recruiting
Low-intensity focused ultrasound for hand tremor
This study uses low-intensity focused ultrasound to stimulate a deep brain area and reduce hand tremors. It is for people with Parkinson's disease, essential tremor, or dystonic tremor whose medications don't work well enough.
Hsinchu, Hsinchu CityAges 18–80 - NCT07220005Recruiting
Focused ultrasound for stroke recovery
This study tests a gentle sound wave therapy (focused ultrasound) to see if it can help improve arm movement in people who had a stroke at least 6 months ago. It aims to find the best settings for this treatment.
Durham, North CarolinaAges 21 years+ - NCT05417555Recruiting
Focused ultrasound for mild memory problems and early Alzheimer’s
This trial studies whether a low-intensity focused ultrasound treatment can improve brain function in people with mild cognitive impairment (early memory decline) or mild Alzheimer’s disease. It may help slow symptoms or improve how the brain works, but it’s still being tested.
Los Angeles, CaliforniaAges 50–90 - NCT06496971RecruitingPhase 3
Testing focused ultrasound plus Avastin for recurrent glioblastoma
This study tests whether adding focused ultrasound to the standard drug Avastin (bevacizumab) can help treat recurrent glioblastoma. The ultrasound may help more of the drug reach the tumor.
TaipeiAges 18–80 - NCT07076472RecruitingEarly Phase 1
Sound and drug therapy for recurrent glioblastoma
This trial tests a new approach that combines a drug (SONALA-001 or 5-ALA) with focused ultrasound to treat glioblastoma that has come back or is growing despite standard treatments. The drug makes tumor cells sensitive to sound waves, and the ultrasound waves are directed at the tumor using MRI guidance. This may help damage cancer cells while sparing healthy brain tissue.
Rochester, MinnesotaAges 18 years+ - NCT07179328RecruitingPhase 1
Focused ultrasound for glioblastoma during standard chemo
This trial tests whether focused ultrasound can safely open the blood-brain barrier to help your chemotherapy work better. It is for people with glioblastoma who have already completed standard surgery and chemo-radiation and are now on maintenance chemo.
Toronto, OntarioAges 18–85 - NCT06283758Recruiting
Ultrasound treatment for kidney fat to lower blood pressure
This trial tests a new ultrasound treatment that targets the fat pad around your kidney to lower blood pressure. It might be an option if your blood pressure is still high despite medication and you meet the size requirements for the fat pad.
Nanjing, JiangsuAges 18–65 - NCT07616440Recruiting
Ultrasound drug delivery with chemotherapy for HER2-positive breast cancer
This study tests a new technique that uses focused ultrasound to deliver cancer drugs directly to breast tumors, combined with standard chemotherapy. The goal is to improve treatment effectiveness for HER2-positive breast cancer before surgery.
Hangzhou, ZhejiangAges 18–70 - NCT03192436Recruiting
Safety study using brain mapping with focused ultrasound
This study tests the safety of a brain stimulation approach that uses special brain recording and “focused ultrasound” targeted by brain signals. It is designed for healthy adults and checks whether the procedure is tolerated without serious side effects.
Pittsburgh, PennsylvaniaAges 18–64 - NCT07518927Enrolling by invitation
Brain Mapping Study Using Ultrasound and Implanted Electrodes
This research study uses focused ultrasound waves combined with brain electrodes (already implanted for your epilepsy or psychiatric treatment) to map how your brain responds. The goal is to better understand brain function and potentially improve future treatments.
Philadelphia, PennsylvaniaAges 21–75 - NCT07220655Recruiting
How focused ultrasound affects thinking and brain activity
This trial uses low-intensity focused ultrasound (LIFU) and brain scans to see how it affects thinking. It may help researchers find new ways to treat brain conditions.
Minneapolis, MinnesotaAges 18 years+ - NCT07161518Enrolling by invitationPhase 4
Testing focused ultrasound on the brain during sedation
This trial uses focused ultrasound to gently stimulate parts of the brain while you are under sedation. It aims to understand how this technology affects brain activity and could lead to new ways to treat brain disorders without surgery.
Palo Alto, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for focused ultrasound?
- Yes. Clin2 currently lists 104 recruiting focused ultrasound studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a focused ultrasound trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a focused ultrasound trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.