Clinical trials
Frail Elderly clinical trials
Below are recruiting frail elderly clinical trials, each written for real people, not researchers. We’re tracking 48 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06645847Recruiting
Ketone drink for walking and strength in older adults
This study tests whether a special ketone drink can help older adults who are starting to feel frail (slower walking, less energy). You would be assigned to one of several groups, and researchers will check if the drink improves your strength and daily function.
Novato, CaliforniaAges 65 years+ - NCT03209414Recruiting
Study of frailty in heart patients receiving heart care
This trial looks at “frailty,” meaning reduced strength and resilience, in older adults with coronary artery disease who are getting heart care. It may help doctors better understand which patients are more at risk and how care decisions could be improved.
Zabrze, Upper SilesiaAges 65 years+ - NCT05710809Recruiting
Exercise and health check study for older colorectal cancer patients
This trial looks at sarcopenia (loss of muscle strength/size) and vertigo (feeling dizzy or off-balance) in older adults with colorectal cancer. It tests whether a structured, exercise-based approach can help these issues alongside cancer care.
CopenhagenAges 65 years+ - NCT05830942Recruiting
Training walks plus brain stimulation for thinking skills in older adults
This study tests whether a structured walking exercise, combined with brain stimulation and brain scans, can improve or slow decline in thinking skills. It’s aimed at older adults who notice memory or confusion getting worse.
Gainesville, FloridaAges 65 years+ - NCT05935618Recruiting
Occupational therapy rehab for frail older adults with swallowing trouble
This trial tests an occupational therapy–based rehabilitation program to help frail older adults with swallowing problems work more safely and comfortably. You may be considered if your swallowing screen results fall in a specific range and you can participate in the therapy and consent process.
HvidovreAges 65 years+ - NCT06208527RecruitingPhase 2
Nicotinamide Riboside for Frailty in Older Adults
This trial tests whether a daily supplement called nicotinamide riboside can help older adults who feel weak or frail to get stronger and more energetic. It lasts for several months and involves simple tests like a walking test and memory checks.
Bergen, VestlandAges 75 years+ - NCT06444321Recruiting
Integrated care for frail patients with heart failure
This trial tests a special care program for people with both frailty (being weak or vulnerable) and heart failure (when the heart doesn't pump well). The program brings together different types of support to help you manage your health better after a hospital stay.
Drammen, AkershusAges 18 years+ - NCT06530511RecruitingPhase 2
PRO trial for elderly, frail patients with a type of lymphoma
This trial tests a combination of three drugs (Polatuzumab, Rituximab, and Orelabrutinib) for elderly patients who are frail or over 80 with a specific type of untreated diffuse large B-cell lymphoma (non-GCB DLBCL). The goal is to see if this drug combo is safe and effective for those who may not tolerate standard chemotherapy.
Nantong, JiangsuAges 60 years+ - NCT06671353Recruiting
Video decision support for advance care planning in frail older adults
This trial tests if watching a video helps older adults with frailty make informed decisions about future medical care. You may be able to join if you are 65 or older, have been diagnosed with frailty, and can watch a video and sign a consent form.
TaipeiAges 65 years+ - NCT06857981Recruiting
Prepare for Your Surgery: A Program for Frail Patients
This trial is for people who are frail and planning to have elective surgery in at least 4 weeks. It focuses on a program to help you prepare for your surgery, so you may have a better recovery.
Santiago, Santiago MetropolitanAges 18 years+ - NCT07015112Recruiting
Medication check for older adults with multiple conditions
This trial tests a team-based approach to review and improve medication use for older adults (65+) who have three or more chronic conditions and are staying in an intermediate care hospital. The goal is to make sure your medicines are as safe and effective as possible.
Barcelona, BarcelonaAges 65 years+ - NCT07303166Recruiting
Osteoporosis care decisions for frail elderly patients
This study learns from doctors in Alsace who treat osteoporosis in frail older patients. It aims to understand what helps or hinders their use of a practical guide. If you are a doctor who has used this guide, your insights could improve future care.
StrasbourgAges 18 years+ - NCT07433153Recruiting
Phone vs. class for fall prevention in older adults
This trial compares two ways to do fall-prevention exercises: using a smartphone app or joining a community class. It may help older adults who are at risk of falling improve their balance and strength.
Binghamton, New YorkAges 55 years+ - NCT07441382Recruiting
Comparing treatments for frail older adults with atrial fibrillation
This study tests whether combining a heart procedure (catheter ablation) with a device to close the left atrial appendage (LAAO) is safer or better than blood thinners alone for frail patients 75 years or older with atrial fibrillation and high stroke risk. It aims to find a treatment that reduces stroke while lowering bleeding risks.
Guangzhou, GuangdongAges 75 years+ - NCT07463352Recruiting
Pre-surgery nutrition for frail seniors with hip fractures
This study tests if giving a special protein drink before surgery helps frail older adults with a broken hip recover better. It might reduce complications after surgery.
DüzceAges 65 years+ - NCT07597850RecruitingPhase 2
TCM formula versus HMB supplement for muscle strength in older adults
This study compares a traditional Chinese medicine formula with HMB (a muscle-building supplement) to see which helps preserve muscle strength and bone health in adults aged 65 and older who are starting to show signs of frailty. Both treatments aim to help you stay stronger and more active as you age.
TaipeiAges 65 years+ - NCT03675724Enrolling by invitationPhase 2
Fisetin for frailty and inflammation in older adults
This trial studies whether fisetin, a supplement-like drug, can reduce frailty and inflammation in people age 70 and older. It may help improve health measures related to aging, but you must meet several safety and medication rules to join.
Rochester, MinnesotaAges 70 years+ - NCT04765514RecruitingPhase 2
Chemo with radiation versus chemo alone for older brain tumor patients
This trial compares two standard treatments for newly diagnosed glioblastoma (a serious brain cancer) in older and frail patients: chemo plus radiation versus chemo alone. It may help determine which approach works best and is safest for people in your age and health group.
Calgary, AlbertaAges 65 years+ - NCT05557552Recruiting
Chemo and immunotherapy plus chest radiation for stage III lung cancer
This trial studies a treatment plan that combines chemotherapy, immunotherapy, and radiation to the chest for people with unresectable stage III non-small-cell lung cancer (NSCLC). It may help by delivering anti-cancer drugs while also shrinking tumors with targeted radiation, especially for people who are not able to have the standard “chemo and radiation at the same time.”
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05952024RecruitingPhase 2
Acalabrutinib plus rituximab for older untreated DLBCL
This trial studies the combination of acalabrutinib and rituximab in older or frail people with newly diagnosed DLBCL (a type of lymphoma). It aims to see how well this treatment works and how safe it is for people who may not be able to tolerate standard chemotherapy.
Berkeley, CaliforniaAges 65–99 - NCT06202118Recruiting
Alpha radiation therapy for breast cancer in older or frail patients
This trial tests a new type of radiation therapy (DaRT) that uses tiny, implantable seeds to deliver targeted alpha radiation to breast tumors. It is designed for older patients (65+) or those who are too frail for surgery, offering a less invasive option for controlling the cancer.
JerusalemAges 65–120 - NCT06552234RecruitingPhase 2
Study of repotrectinib for older or frail patients with ROS1-positive lung cancer
This trial tests an oral targeted therapy called repotrectinib in people with advanced non-small cell lung cancer (NSCLC) that has a change in the ROS1 gene. It is designed for patients who are either 70 or older, or have a lower performance status (ECOG 2 or higher), meaning they may be more frail or have more symptoms. The goal is to see if repotrectinib can help shrink or control the cancer.
Aix-en-Provence, Bouches Du RhôneAges 18 years+ - NCT07259499Recruiting
Predictors of emergency visits in frail older adults
This study looks at why frail older adults go to the emergency room. Researchers want to see if blood tests and brain scans can help predict who needs emergency care. Participation involves one interview and having had a recent brain scan and blood work.
Pisa, PisaAges 65 years+ - NCT04012840Recruiting
Prevention program study for frailty risk in older adults
This study looks at what makes older adults become frail and checks whether a prevention-focused geriatric assessment and regular follow-up can help. If you’re at risk for frailty, you may be asked to join assessments and answer follow-up calls for three years.
Paris, Île-de-France RegionAges 70 years+
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Common questions
- Are there clinical trials for frail elderly?
- Yes. Clin2 currently lists 48 recruiting frail elderly studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frail elderly trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frail elderly trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.