Clinical trials
Frailty clinical trials
Below are recruiting frailty clinical trials, each written for real people, not researchers. We’re tracking 265 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05625204Recruiting
HIIT exercise program to improve frailty in older veterans
This trial tests a high-intensity interval training (HIIT) exercise program to help older veterans feel stronger and more resilient and to reduce frailty. It may help people who are not yet very frail (or are just starting to become frail) but can safely exercise.
Kansas City, MissouriAges 65 years+ - NCT05257954Recruiting
Testing frailty in people getting a left atrial appendage closure
This study looks at frailty (how strong or vulnerable a person is) in adults who are having a left atrial appendage closure procedure through a catheter. The goal is to understand which patients may be more vulnerable during or after the procedure.
Québec, QuebecAges 18 years+ - NCT03458429Enrolling by invitationPhase 1/Phase 2
Plasma from healthy donors for frailty and immune health
This Phase 1/2 study tests whether transfusions of donated plasma can improve frailty and immune function in older adults. It mainly checks safety first, and also looks for signs that the immune system and overall strength may improve.
Boynton Beach, FloridaAges 55–95 - NCT05018767RecruitingPhase 1
Testing an IV stem cell treatment for aging frailty safety
This early study (Phase 1) tests whether a lab-made stem cell product given through an IV is safe in people with “aging frailty.” It looks mainly at side effects and safety while also exploring whether the treatment can be given safely.
St John'sAges Any age - NCT07183033Enrolling by invitation
VR brain training for older adults with mild memory and health issues
This trial uses virtual reality exercises to see if they can help improve brain function in older adults who have some memory concerns and physical frailty. Researchers want to know if a fun, interactive VR program can strengthen connections in the brain and improve daily life.
Beijing, Beijing MunicipalityAges 60 years+ - NCT06704256Recruiting
Using neck muscle scans to predict frailty before ENT surgery
This study looks at neck CT scans to see if muscle size can help predict frailty in people having ear, nose, or throat surgery. It may help doctors better prepare for your recovery.
New York, New YorkAges 18 years+ - NCT05922202Recruiting
Studying how frailty affects outcomes in COPD
This study looks at whether frailty (how weak or vulnerable someone is) changes the risk of heart-related events and death in people with COPD. It may help doctors better predict who is at higher risk and tailor care.
ModenaAges 40 years+ - NCT06507527Recruiting
Frailty in older adults having outpatient digestive endoscopy
This study looks at frailty in older adults (70+) who are having an outpatient digestive endoscopy. It aims to understand how frailty affects the procedure and recovery.
BarcelonaAges 70–100 - NCT06503198Recruiting
Virtual postsurgical care for older adults with frailty
This trial tests whether virtual care after surgery helps older adults with frailty recover at home instead of going to a nursing home or rehab. You'll get check-ins via video or phone to support your recovery.
Ottawa, OntarioAges 60 years+ - NCT07345832Recruiting
Volunteer-led lifestyle program for older adults with muscle loss
This study tests a volunteer-led program to improve muscle health in older adults with sarcopenia. It uses a mobile app to guide exercise and nutrition, and aims to see if this approach helps people regain strength.
Hong KongAges 60 years+ - NCT07733726Enrolling by invitation
Dual-Task Mouth and Memory Training for Oral Frailty
This study tests a program that combines mouth exercises with memory tasks to see if it can improve both chewing, swallowing, and thinking skills in people who have oral frailty and some memory decline.
KowloonAges 50 years+ - NCT07029243Recruiting
Prehabilitation and supplement for frail cirrhosis patients
This study tests whether a prehabilitation program (exercise and nutrition planning) along with a supplement containing creatine and whey protein can help improve strength and well-being in people with cirrhosis who are frail. The goal is to see if this combination can help you feel stronger and more active.
San Francisco, CaliforniaAges 18 years+ - NCT03824106Recruiting
Frailty rehab program for older adults at YMCA
This trial studies a rehabilitation (rehab) program to help older adults who are at risk of losing mobility and independence. You may be offered group-based rehab at the YMCA if you meet age, mobility, safety, and participation requirements.
Hamilton, OntarioAges 65 years+ - NCT04524247Recruiting
Testing a custom stent graft for frail aortic aneurysms
This study looks at a specialized, customized stent graft to treat certain aneurysms (bulges) of the aorta in people who may be considered frail. It’s meant to see how well the device works and how safely it can be used in patients who fit specific aneurysm patterns.
Los Angeles, CaliforniaAges 18 years+ - NCT05078957Recruiting
Study gut microbiome in older adults with well-controlled HIV
This trial studies how the bacteria in your gut (“microbiome”) relate to frailty (weakness/low physical resilience) in people with HIV who are stably doing well on treatment. It may help researchers understand why some people become frail and how the gut may play a role.
MarseilleAges 55 years+ - NCT05091645Recruiting
Testing a Greek version of a frailty screening for hip fracture patients
This trial checks whether a translated and culturally adapted questionnaire (called the Groningen Frailty Indicator) works well for people age 65+ who have a hip fracture and are having surgery. It may help care teams better understand frailty and plan support after surgery.
LarissaAges 65 years+ - NCT05292989Recruiting
Using a frailty checklist to help older people choose care
This study looks at how a personalized “frailty” checklist can help older adults (65+) understand their health and make better choices. You may be asked to complete questionnaires and a frailty-type assessment to see if the approach works for you.
Woolloongabba, QueenslandAges 65–100 - NCT05694338Recruiting
Study frailty during major surgery for gut cancer
This trial studies how “frailty” affects people with gastrointestinal (gut) cancer who are about to have major surgery, sometimes after chemotherapy or other treatment beforehand. It may help doctors better prepare and support patients through surgery.
East Corning, New YorkAges 18 years+ - NCT05928767Recruiting
Using frailty scores to predict death in ICU sepsis
This trial checks whether a “frailty” rating (how physically/mentally vulnerable someone is) can predict the risk of death in ICU patients with sepsis shock. It may help doctors identify higher-risk patients earlier and tailor care.
BéthuneAges 18–65 - NCT05946174Recruiting
Personalized frailty program for older people with heart frailty
This trial aims to adjust frailty-support activities for people who are physically vulnerable because of heart problems. It may help by creating a plan tailored to your needs, while carefully checking health issues that could make participation unsafe.
SingaporeAges 21–100 - NCT05987982Recruiting
Does mouth odor help prevent pneumonia from oral frailty?
This trial looks at whether checking your mouth odor can help prevent pneumonia in people who have weak oral health (called oral frailty). You'll get an oral assessment and be followed to see if it helps lower the risk of pneumonia.
TainanAges 50 years+ - NCT05993754Recruiting
Preventing confusion after surgery in frail older adults
This study tests whether a special nursing care plan can help prevent confusion after surgery in older adults who are frail. If you are 65 or older, having planned surgery, and generally healthy enough, this trial may be an option.
Santiago, Santiago MetropolitanAges 65 years+ - NCT06055387Recruiting
Frailty care for older stomach cancer patients after surgery
This study tests a frailty assessment and intervention program for people aged 65+ with stage II or III stomach cancer who will have surgery and chemotherapy afterward. It aims to improve recovery and quality of life.
Taoyuan, TaiwanAges 65 years+ - NCT06099912Recruiting
Personalized frailty-based treatment for older adults with new multiple myeloma
This trial tests a personalized treatment approach for people aged 65 and older with newly diagnosed multiple myeloma. The goal is to tailor therapy based on each patient's level of frailty, which could help improve outcomes and reduce side effects.
Changchun, JilinAges 65 years+
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Common questions
- Are there clinical trials for frailty?
- Yes. Clin2 currently lists 265 recruiting frailty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frailty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frailty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.