Clinical trials
Frailty clinical trials
Below are recruiting frailty clinical trials, each written for real people, not researchers. We’re tracking 245 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05291676RecruitingPhase 2
Study how vaccines work in aging and frailty adults
This trial studies how well your immune system responds to a vaccine in people who are younger adults or, especially, older adults and those with frailty. Your participation may help researchers understand why vaccine responses can differ with age.
New Haven, ConnecticutAges 21 years+ - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT06911619Recruiting
Nutrition support for liver transplant patients
This study tests whether nutritional support can help reduce frailty in patients waiting for a liver transplant. It aims to improve strength and overall health before surgery.
LyonAges 18 years+ - NCT06896643Recruiting
Urine infections and bone surgery in older adults
This trial looks at whether having a urinary tract infection or bacteria in urine affects recovery after bone surgery. It focuses on people 65 and older who will have surgery for a broken bone or other bone problem.
ZlínAges 65 years+ - NCT06894914Recruiting
Physical activity counseling for older adults with complex health needs
This study looks at ways to help older adults with multiple health conditions get more physical activity. It compares two types of counseling that physiotherapists provide. You may be eligible to take part if you are 65 or older, live in the community, have certain health challenges, and can walk a short distance.
Vancouver, British ColumbiaAges Up to 99 years - NCT06874413Enrolling by invitation
Exercise program for frail older adults before hernia surgery
This study tests whether a supervised exercise program before hernia repair surgery helps frail older adults recover better. The program includes physical exercises and breathing muscle training.
Greenville, South CarolinaAges 65 years+ - NCT06868069Recruiting
Blood pressure changes and frailty in older adults
This study looks at how blood pressure changes over time in older adults with high blood pressure, and how it relates to frailty (a state of increased weakness). The goal is to learn more about managing blood pressure in older people.
MilanAges 75 years+ - NCT06844318Recruiting
IBD treatment and frailty in patients over 60
This study looks at how inflammatory bowel disease (IBD) activity affects frailty in people over 60. It tests whether starting or changing medication for active IBD can help understand and manage frailty.
Vitoria-Gasteiz, AlavaAges 60 years+ - NCT06820021Recruiting
Strength-based exercise program at home for older adults
This study tests a personalized home exercise program to help older adults regain strength and independence after a hospital stay. If you are 60 or older, had a recent hospital stay of at least 2 days, and are at risk of losing function, this program may help you stay active and recover better.
Hong KongAges 60 years+ - NCT06796894Recruiting
Asthma symptoms, breathing, and frailty study
This study looks at symptoms, breathing problems, and frailty in people with allergic or eosinophilic asthma. It aims to understand how these factors relate to each other.
Ankara, StateAges 35–75 - NCT06802991Recruiting
Optimized post-discharge care for older colon cancer patients
This trial tests better nutrition and follow-up care for older patients after colon cancer surgery. It focuses on people who are somewhat frail and at risk for poor nutrition, to see if extra support at home can improve recovery.
HerlevAges 65 years+ - NCT04715581Recruiting
Pre-surgery rehab program for frail older adults having stomach surgery
This trial studies a “prehabilitation” program—exercise and coaching before surgery—to help frail older adults recover better after major digestive cancer surgery. It may help you strengthen your body and function before the operation, which can improve outcomes after surgery.
Beijing, Beijing MunicipalityAges 65–89 - NCT06069297Recruiting
Prehabilitation before pancreatic cancer surgery
This trial tests whether a pre-surgery program of exercise and nutrition (called prehabilitation) can help people with pancreatic cancer recover better after surgery. Participants will receive guidance on physical activity and diet before their operation.
Milan, LombardyAges 18 years+ - NCT06036615Recruiting
Exercise training for frailty and fall risk in heart failure
This trial tests whether a supervised exercise program can reduce frailty and fall risk in people with chronic heart failure, and what happens when training stops. It may help you feel stronger and more stable.
Thessaloniki, ThermiAges 18–100 - NCT06687291Recruiting
Thinking and memory after stomach or esophagus cancer surgery
This study looks at how surgery and chemotherapy for stomach or esophageal cancer may affect your thinking, memory, and other cognitive functions. Researchers want to understand these changes to better support patients.
HuddingeAges 18 years+ - NCT06645847Recruiting
Ketone drink for walking and strength in older adults
This study tests whether a special ketone drink can help older adults who are starting to feel frail (slower walking, less energy). You would be assigned to one of several groups, and researchers will check if the drink improves your strength and daily function.
Novato, CaliforniaAges 65 years+ - NCT06611228Recruiting
Preventing disability in older hospital patients
This study tests if a program designed for older, frail hospital patients can prevent loss of ability to do daily tasks. It focuses on physical activity, mental engagement, and nutrition to help you stay independent.
Monza, LumbardyAges 70 years+ - NCT06586970Recruiting
Meals plus therapy to prevent falls for older adults
This study tests whether adding occupational therapy and dietitian services to home-delivered meals helps older adults stay safe and reduce falls. It's for people who are homebound, can't have a caregiver cook for them, and live in central Ohio.
Columbus, OhioAges 60 years+ - NCT06554717RecruitingPhase 2
Tesamorelin and exercise for physical function in HIV
This study tests whether adding tesamorelin to an exercise program helps older adults with HIV improve their physical function and reduce belly fat. It is designed for people who are mostly sedentary and show early signs of frailty.
Aurora, ColoradoAges 50–80 - NCT06516198Recruiting
Ear acupressure before lung surgery
This study tests whether ear acupressure can help people get stronger before major lung surgery. You'll wear small seeds on your ears and do exercise prehabilitation.
Chicago, IllinoisAges 50 years+ - NCT06502275Recruiting
Nutrition and Exercise for Older Colorectal Cancer Patients
This trial tests a nutrition and exercise program designed for older adults with colorectal cancer. It uses a smartphone app to help you stay active and eat well at home.
Chiayi CityAges 60 years+ - NCT06469437Recruiting
Geriatric check for older adults with type 2 diabetes
This study looks at how a full health check for older adults with type 2 diabetes can help doctors choose the best treatment plan. It aims to improve care for people 60 and older.
Porto Alegre, Rio Grande do SulAges 60 years+ - NCT06359652Recruiting
Get Fit for Function: Exercise before lung surgery
This study tests a program to help you get stronger before lung surgery. It may improve your recovery after the operation.
Chicago, IllinoisAges 18 years+ - NCT06374537Recruiting
Exercise program for weak kidney patients
This study tests whether a targeted exercise program can help people who are very weak due to kidney disease. If you are on dialysis, have advanced kidney disease, or have had a kidney transplant, this program may improve your strength and daily function.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for frailty?
- Yes. Clin2 currently lists 245 recruiting frailty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a frailty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a frailty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.