Clinical trials
Genetic Variation clinical trials
Below are recruiting genetic variation clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03294460RecruitingPhase 1
Genetic study of smoking and alcohol response in healthy adults
This Phase 1 study tests whether certain genes linked to nicotine receptors affect how people feel and respond to alcohol. It also compares alcohol responses in smokers versus non-smokers using brain imaging (MRI) and alcohol-earning/reward tasks, aiming to better understand why some people may crave alcohol more than others.
Bethesda, MarylandAges 21–60 - NCT03781752RecruitingPhase 4
Test of methylphenidate effects based on a genetic difference
This trial studies whether a genetic difference called “carboxylesterase 1” changes how methylphenidate (a common ADHD medicine) works for children with ADHD. It’s a single-dose test, meant to help understand why some children respond differently to ADHD medication.
Gainesville, FloridaAges 6–17 - NCT04151342Recruiting
Study of Canadian adults with cancer rare DNA changes
This real-world study follows adults in Canada who have cancer that was tested and found to have rare molecular (DNA/protein) changes. It helps researchers understand how these rare findings show up and how care happens in everyday practice.
Calgary, AlbertaAges 18 years+ - NCT05359796Recruiting
Study of long-term type 1 diabetes symptoms and characteristics
This study looks at what day-to-day health and medical features are like in people who have had type 1 diabetes for many years. It may help researchers better understand long-term needs in type 1 diabetes and guide future care.
Changsha, HunanAges Any age - NCT07062588RecruitingPhase 2
AGA2115 for osteogenesis imperfecta in adults with COL1A1/COL1A2 variations
This trial tests a new drug called AGA2115 for people with osteogenesis imperfecta (also known as brittle bone disease) who have a confirmed genetic change in the COL1A1 or COL1A2 genes. The study aims to see if the drug can help strengthen bones and reduce fracture risk.
Phoenix, ArizonaAges 18–75 - NCT06996561RecruitingPhase 2/Phase 3
How your genes affect pain relief after surgery
This study looks at how your genes might affect pain relief from a medication called nalbuphine after abdominal or pelvic surgery. It aims to personalize pain management based on your genetic makeup.
Karachi, SindhAges 18–70 - NCT07086924Recruiting
Gene change and methotrexate response in psoriasis
This study looks at a specific gene change (called TRAF3IP2) in people with psoriasis or psoriatic arthritis who are about to start methotrexate. The goal is to see if the gene affects how well the treatment works or if it causes side effects.
QinaAges 18–70 - NCT07135427RecruitingPhase 4
Genes and vaccines in alpha-1 antitrypsin deficiency
This study looks at how genetic differences in alpha-1 antitrypsin deficiency affect immune response to a pneumonia vaccine. It may help find better ways to prevent lung infections.
Birmingham, AlabamaAges 19 years+ - NCT00710177Recruiting
Study genes and risk of persistent lung blood pressure in newborns
This study looks at a newborn’s genes (PTGS1 variation) and whether that relates to persistent pulmonary hypertension of the newborn (PPHN), a serious breathing/lung blood-pressure problem. It may help doctors understand who is at higher risk and how to better identify affected babies early.
Milwaukee, WisconsinAges Up to 1 year - NCT06914726Enrolling by invitation
Cancer risk follow-up care for hereditary syndromes
This study tests a tool to help primary care doctors provide better cancer prevention care for people with hereditary breast and ovarian cancer (HBOC) or Lynch syndrome (LS). It aims to ensure you're up-to-date on recommended screenings and preventive steps.
Minneapolis, MinnesotaAges 18 years+ - NCT05327283Recruiting
Genetic testing for early menopause in younger people
This study looks at DNA changes to understand the cause of premature ovarian insufficiency (early menopause). It may help clarify what’s happening in your body and guide future care.
GenovaAges 15–38 - NCT05767216Recruiting
Study of genetic and epigenetic differences in twin pairs with Down syndrome
This study looks at how genetics and gene-regulation (how genes turn on and off) differ between close family members who have different Down syndrome status. Researchers hope the findings will help explain why Down syndrome outcomes can vary even in very closely related people.
ParisAges 4–11 - NCT05364294Recruiting
Molecular testing for rare inflammatory (autoinflammatory) diseases
This study uses lab testing to better identify the cause of certain rare inflammatory conditions that happen without infection. Finding the cause may help doctors choose more targeted care for you or your child.
ParisAges 1 week–120 years - NCT06886672Recruiting
Genetic study in pleural mesothelioma
This study looks at the role of inherited genes in malignant pleural mesothelioma. It includes people recently diagnosed and healthy people who were exposed to asbestos. The goal is to better understand why some people get this cancer.
Pavia, PaviaAges 18 years+ - NCT00710112Recruiting
Genetic risk study in very low birth-weight babies
This study looks at genetic differences to understand why some very low birth-weight babies develop certain health problems. It may help doctors predict risk and tailor care for these babies.
Milwaukee, WisconsinAges Any age
Hear when a new Genetic Variation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for genetic variation?
- Yes. Clin2 currently lists 15 recruiting genetic variation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a genetic variation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a genetic variation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.