Clinical trials
Genetic Mutations clinical trials
Below are recruiting genetic mutations clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06340646Recruiting
Washington University cancer gene study
This study collects genetic information from people with certain cancers to learn more about cancer risks and outcomes. It may help researchers understand how genes affect cancer in different groups.
St Louis, MissouriAges 18 years+ - NCT05691036Recruiting
Studying bile acid levels and genes in pregnancy itching
This study looks at bile acid levels and possible genetic changes in people with persistent pregnancy itching. The goal is to better understand the cause of intrahepatic cholestasis of pregnancy and related pregnancy outcomes.
Chandigarh, ChandigarhAges 21–45 - NCT03538639Recruiting
Study blood and tissue samples for vascular disease discovery
This study collects blood (and sometimes tissue samples) from people who may have vascular (blood vessel) problems and from certain pregnant participants. Researchers use the samples to better understand vascular disease and to help guide future research.
Bethesda, MarylandAges 2–100 - NCT06277466Recruiting
Gene changes and diabetes risk study
This study looks at how certain gene changes affect blood sugar control in type 2 diabetes and also in people who have had pancreas surgery. It compares these groups with healthy volunteers to see how genes influence the risk of diabetes.
XuzhouAges 25–70 - NCT05129605Recruiting
Prostate cancer genetic risk screening study for men
This study looks at your personal and family risk for prostate cancer and helps decide who should have extra screening like MRI. It may help you find cancer earlier if you are at higher genetic risk.
Boston, MassachusettsAges 35–74 - NCT03544983Enrolling by invitation
Genetic education program for BRCA family members
This trial offers education about BRCA1 and BRCA2 gene mutations to help families understand testing, cancer risk, and next steps. It may be helpful if you are a family member of someone who recently learned they have a BRCA mutation.
Washington D.C., District of ColumbiaAges 21–75 - NCT06089421Recruiting
Genetic information assistant for cancer risk testing
This study tests a tool called GIA (Genetic Information Assistant) that helps people understand genetic testing for cancer risk. You would use the tool on a smartphone or computer during a genetic counseling session.
Charlottesville, VirginiaAges 18 years+ - NCT06792721Recruiting
Measuring mutation levels in siblings with BRCA risk
This study looks at how genetic mutations (changes in DNA) are measured in the blood of sisters. One sister has a BRCA1 or BRCA2 gene mutation that raises cancer risk, and the other does not. The goal is to understand mutation differences between them.
Caen, FranceAges 30–50 - NCT05898009Recruiting
Study BRCA2 gene changes in breast cancer in Reunion
This study looks at how often certain BRCA2 gene changes occur in people in Réunion who have breast cancer. Your participation may help doctors understand breast cancer risk in the local community and guide future care.
Saint-PierreAges 18 years+ - NCT05420064Recruiting
Help with family cancer gene testing and unclear results
This trial helps people and their doctors understand and act on genetic test results, including when results are uncertain. It tests whether a structured approach improves who gets tested in families and helps patients and primary care providers stay up-to-date.
Basking Ridge, New JerseyAges 25 years+ - NCT06584994Enrolling by invitation
Genetics and cancer risk in families
This study looks at how genes passed down in families might increase the chance of getting cancer. It collects samples from children with cancer and their family members to better understand cancer risks.
CambridgeAges Any age - NCT05848271Recruiting
Natural history study for people with HPDL gene changes
This study follows people who have an HPDL gene change to better understand how symptoms and health progress over time. It may help clinicians learn more about the condition and plan future treatments.
San Diego, CaliforniaAges Any age - NCT06642168Recruiting
Genetic Testing for Sudden Cardiac Arrest in Young Athletes
This study looks at young people who had a sudden cardiac arrest during sports. Doctors will check for genetic causes to help prevent future events in athletes and their families.
Paris, FranceAges 12–35 - NCT05552157RecruitingPhase 2/Phase 3
Study of treatments for early onset Alzheimer's caused by genetic mutations
This trial tests potential treatments for people who are at risk for or have early onset Alzheimer's disease due to a specific genetic mutation. It aims to find treatments that could slow or prevent symptoms.
Birmingham, AlabamaAges 18 years+ - NCT06647498RecruitingPhase 2/Phase 3
Study of a treatment for early-onset Alzheimer's caused by a gene change
This study tests a potential disease-modifying treatment for people who have a specific gene mutation that causes early-onset Alzheimer's disease. The goal is to see if the treatment can delay or prevent symptoms.
Birmingham, AlabamaAges 18 years+ - NCT07329257Recruiting
Project PENGUIN: Study of rare brain development disorders
This study looks at rare and ultra-rare conditions that affect brain development. It aims to learn more about what causes these conditions. You may join if you or your child have a diagnosed or suspected neurogenetic disorder.
Columbia, MissouriAges Up to 99 years - NCT02775461Recruiting
Registry for people at high risk for pancreatic cancer
This study is a registry (a way to track health over time) for people with a strong family history or certain inherited genetic risks for pancreatic cancer. It may help doctors learn how best to monitor and protect high-risk people, and to see who benefits most from follow-up.
New York, New YorkAges 18 years+ - NCT07498829Recruiting
Cancer risk genetic testing for people with female organs
This study offers free genetic testing to women, trans men, and non-binary people (with female reproductive organs) who have not had previous testing for certain cancer-related genes. It aims to find people at higher risk for cancer so they can take steps to prevent it or catch it early.
LondonAges 18 years+ - NCT06722313Enrolling by invitation
Better embryo genetic testing for couples without an affected child
This trial is testing a new, more efficient way to perform genetic testing on embryos (PGT-M) for couples who do not have a DNA sample from an affected child. It aims to help families where standard methods are difficult, such as when the carrier has no symptoms, or when the female partner has low egg reserve.
Shanghai, Shanghai MunicipalityAges Any age - NCT01689584Recruiting
Study of genetic variants in cancer families
This study looks at how a specific DNA genetic change (variant) runs within cancer families. It may help researchers better understand cancer risk and improve genetic testing and interpretation.
Bastia, CorsicaAges 18 years+ - NCT05364294Recruiting
Molecular testing for rare inflammatory (autoinflammatory) diseases
This study uses lab testing to better identify the cause of certain rare inflammatory conditions that happen without infection. Finding the cause may help doctors choose more targeted care for you or your child.
ParisAges 1 week–120 years - NCT07215416RecruitingPhase 1/Phase 2
Gene therapy for ataxia-telangiectasia with specific ATM mutation
This trial tests a new genetic medicine designed for people with A-T who have a specific ATM gene change. It aims to see if the treatment is safe and if it can improve symptoms.
Boston, MassachusettsAges birth–17 years - NCT06659341RecruitingPhase 1
Study of BAY3498264 with Sotorasib for KRAS G12C Cancers
This trial tests a new drug (BAY3498264) combined with sotorasib, a targeted therapy, for people with advanced cancers that have a specific genetic change called KRAS G12C. It's for those who have already tried other treatments and need new options.
Albury, New South WalesAges 18 years+ - NCT06470685Enrolling by invitation
Preventive prostate removal for prostate cancer risk
This study tests whether removing the prostate before cancer develops can help people at higher risk, such as those with certain gene changes (like BRCA2), a strong family history, or Black African/Caribbean ancestry. It also includes people who have already had their prostate removed for cancer treatment.
LondonAges 18 years+
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Common questions
- Are there clinical trials for genetic mutations?
- Yes. Clin2 currently lists 44 recruiting genetic mutations studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a genetic mutations trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a genetic mutations trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.