Clinical trials
Glioblastoma, Adult clinical trials
Below are recruiting glioblastoma, adult clinical trials, each written for real people, not researchers. We’re tracking 32 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06954636Recruiting
Smell test to predict glioblastoma outcomes (newly diagnosed)
This study looks at whether a simple smell test can help predict how glioblastoma will progress. It is for people who are newly diagnosed and have not started treatment yet.
EssenAges 18 years+ - NCT04573140RecruitingPhase 1
RNA vaccine study for newly diagnosed adult and pediatric brain tumors
This Phase 1 trial studies an “RNA-lipid particle” vaccine given after surgery for certain newly diagnosed brain cancers (glioblastoma in adults, high-grade glioma in children/teens). The goal is to see whether the vaccine is safe and can train the immune system to fight the tumor.
Washington D.C., District of ColumbiaAges 4 years+ - NCT07100730RecruitingPhase 3
A new drug for recurrent glioblastoma vs standard care
This trial tests a new targeted drug, TLX101-Tx, added to standard care for people with glioblastoma that has come back after initial treatment. It aims to see if the combination helps control the tumor better than standard care alone.
Gold Coast, QueenslandAges 18 years+ - NCT06146725Recruiting
Resection vs. biopsy in high-grade glioma patients
This study compares whether having surgery to remove as much of the tumor as possible (resection) or just taking a small sample (biopsy) leads to better outcomes for people with a fast-growing brain tumor (high-grade glioma). The goal is to help guide treatment decisions.
San Francisco, CaliforniaAges 18–90 - NCT05353530RecruitingPhase 1
CAR T cell treatment for CD70-positive newly diagnosed glioblastoma
This trial tests a customized immune-cell treatment (CAR T cells) for adults with newly diagnosed glioblastoma (GBM) whose tumors have enough CD70 protein. If you qualify, the goal is to see whether this treatment can better control the cancer by targeting it in the brain.
Gainesville, FloridaAges 18–80 - NCT06991101RecruitingPhase 2
Ruxolitinib with radiation and chemo for new glioblastoma
This trial tests adding ruxolitinib, a targeted drug, to the standard radiation and chemotherapy for newly diagnosed glioblastoma. It aims to see if this combination helps people live longer without their cancer growing.
Miami, FloridaAges 18 years+ - NCT05052957RecruitingPhase 2
Autologous stem cell rescue for newly diagnosed brain tumor
This trial tests giving a patient’s own stem cells back to help the bone marrow recover after treatment for newly diagnosed glioblastoma or gliosarcoma. It may help reduce blood-count problems so treatment can be given more safely.
Cleveland, OhioAges 18–75 - NCT06496971RecruitingPhase 3
Testing focused ultrasound plus Avastin for recurrent glioblastoma
This study tests whether adding focused ultrasound to the standard drug Avastin (bevacizumab) can help treat recurrent glioblastoma. The ultrasound may help more of the drug reach the tumor.
TaipeiAges 18–80 - NCT06283927Recruiting
Surgery vs. medical care for recurrent glioblastoma
This trial compares surgery to the best non-surgical treatment for people whose glioblastoma has come back. The goal is to see which approach helps people live longer with a better quality of life.
San Francisco, CaliforniaAges 18–90 - NCT05954858Recruiting
Surgical flap to help treat glioblastoma by bypassing the blood-brain barrier
This trial tests a surgical technique that places a tissue flap near a glioblastoma surgery site to help medicines reach the brain more effectively. You might be considered if you are planning major brain tumor surgery and meet specific health, imaging, and lab requirements.
New York, New YorkAges 18 years+ - NCT03213002RecruitingPhase 1/Phase 2
CAPTEM pills after brain radiation for newly diagnosed glioblastoma
This trial studies whether taking two chemotherapy pills (capecitabine and temozolomide) after the initial 6-week radiation-and-chemo phase can help people with newly diagnosed glioblastoma. It aims to test safety and early effectiveness right before the usual maintenance temozolomide phase.
New York, New YorkAges 18–74 - NCT07134842RecruitingPhase 1
Immunotherapy before standard brain cancer treatment
This trial tests giving the immunotherapy drug ipilimumab before the usual treatment for newly diagnosed glioblastoma (a type of brain cancer). The goal is to see if this approach is safe and possible, and whether it might help the immune system fight the tumor better.
London, Greater LondonAges 18 years+ - NCT04427384Recruiting
Brain tumor patients treated with GammaTiles registry
This study is a patient registry for people with brain tumors who had surgery to remove as much as safely possible and then had GammaTiles placed. It mainly collects information and follow-up imaging to understand how patients do after the treatment.
Phoenix, ArizonaAges Any age - NCT06805305RecruitingPhase 2
Immunotherapy for newly diagnosed glioblastoma
This trial tests a new personalized immunotherapy (DOC1021) for people with newly diagnosed glioblastoma. The treatment uses your own immune cells to attack the tumor and is given after surgery and with standard chemotherapy and radiation.
Gilbert, ArizonaAges 18 years+ - NCT06146738Recruiting
Palliative care vs. surgery for high-grade glioma patients
This study compares receiving palliative care (supportive treatments) versus surgery (removing the tumor) for people with a high-grade glioma, a fast-growing brain tumor. The goal is to find out which approach improves quality of life and survival.
San Francisco, CaliforniaAges 18–90 - NCT05653622RecruitingPhase 2
FDOPA PET–guided radiation planning for glioblastoma patients
This Phase 2 trial tests a radiation “planning” approach guided by an FDOPA PET scan. It aims to better target glioblastoma tissue in people who can’t follow the standard STUPP treatment plan.
Nancy, DeAges 18 years+ - NCT06389591RecruitingPhase 1
RNA Vaccine for Recurrent Glioblastoma
This trial tests a new personalized RNA vaccine made from your own tumor tissue. It is designed to help your immune system fight the cancer after it has returned. You will have surgery to collect the tumor, and then the vaccine is given to try to stop the tumor from growing again.
Gainesville, FloridaAges 18–80 - NCT07668869Recruiting
Electric fields with targeted radiation vs. alone for recurrent brain cancer
This trial tests whether adding a precise, MRI-guided radiation treatment to tumor-treating electric fields (TTFields) can help people with recurrent glioblastoma. You may qualify if your tumor has come back 1 to 3 times after standard therapy and you haven't had certain prior treatments.
BydgoszczAges 18 years+ - NCT06273176Recruiting
Surgery with or without brain mapping for recurrent glioblastoma
This study is testing whether using a special brain-mapping technique during surgery helps people with recurrent glioblastoma. It compares standard surgery to surgery with mapping to see if it leads to better outcomes for tumors near important brain areas.
San Francisco, CaliforniaAges Up to 90 years - NCT06118723Recruiting
Supramaximal vs maximal surgery for brain tumors
This trial compares removing as much tumor as safely possible (supramaximal resection) with standard maximal resection in people with high-grade glioma (an aggressive brain tumor). The goal is to see if more extensive removal improves survival and quality of life.
San Francisco, CaliforniaAges 18–90 - NCT05765812RecruitingPhase 1/Phase 2
Debio 0123 with temozolomide for recurrent or new glioblastoma
This early-phase study tests Debio 0123 (an anticancer medicine) combined with temozolomide, and for newly diagnosed patients also with radiation. It aims to see whether this treatment combination can slow or control glioblastoma in adults.
Chicago, IllinoisAges 18 years+ - NCT05271240RecruitingPhase 3
Targeted brain-artery drug added to standard treatment for new GBM
This Phase 3 trial tests whether delivering a cancer drug directly into brain blood vessels, along with standard radiation and temozolomide, works better than standard treatment alone in newly diagnosed glioblastoma (GBM). The goal is to improve control of the tumor while comparing side effects between the two approaches.
New York, New YorkAges 18 years+ - NCT06902350RecruitingPhase 1
Experimental drug CS231295 for advanced solid tumors
This trial tests an experimental drug called CS231295 for people with advanced solid tumors that have not responded to standard treatments. The purpose is to study safety and find out if the drug can shrink tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT04541082RecruitingPhase 1
Oral ONC206 for recurrent brain and spinal tumors
This early-phase study tests an oral medicine called ONC206 in adults with recurrent, rare brain or spinal cord tumors. The goal is to find a safe dose and look for signs the treatment can shrink or control the cancer.
Bethesda, MarylandAges 18 years+
Hear when a new Glioblastoma, Adult trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for glioblastoma, adult?
- Yes. Clin2 currently lists 32 recruiting glioblastoma, adult studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a glioblastoma, adult trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a glioblastoma, adult trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.