Clinical trials
Head and Neck Carcinoma clinical trials
Below are recruiting head and neck carcinoma clinical trials, each written for real people, not researchers. We’re tracking 504 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07020117RecruitingPhase 1
Study of AKY-1189 for advanced solid tumors
This trial tests a new radioactive drug, AKY-1189, for people with solid tumors that have spread or cannot be removed. It may help if other treatments have stopped working.
Duarte, CaliforniaAges 18 years+ - NCT06666881Recruiting
Exercise training for head and neck cancer patients
This trial studies if exercise training can improve outcomes for people with head and neck squamous cell cancer who need chemotherapy and radiation. It uses body scans to see if muscle changes from exercise are linked to better prognosis.
New Taipei CityAges 20–80 - NCT07546045Recruiting
Robotic Surgery and Swallowing Recovery for Head and Neck Cancer
This trial tests a specialized robotic surgical approach for head and neck cancers, combined with personalized speech and swallowing rehabilitation. The goal is to remove tumors while preserving organ function and improving your ability to swallow and speak after surgery.
LausanneAges 18 years+ - NCT06161779Recruiting
Reconstructing the hypopharynx after cancer removal
This trial tests a surgical technique using a flap from under your chin to rebuild the hypopharynx after removing cancer. It may help people with hypopharyngeal cancer that has not spread far and who have not had radiation before.
Guangzhou, GuangdongAges 18–80 - NCT04999761RecruitingPhase 1
Study testing new drug combinations for advanced cancers
This study tests new drug combinations for people with various advanced cancers that have progressed after standard treatment, or in some cases, as a first treatment. It aims to see if these combinations are safe and effective. The study is divided into groups based on cancer type and treatment history, so not everyone will qualify for every group.
AichiAges 18 years+ - NCT03238378Recruiting
Radiation boost plus warming for recurrent head and neck tumors
This trial tests a “salvage” treatment that combines targeted radiation (brachytherapy) with controlled body warming (hyperthermia) for head and neck cancer that has come back. It may help by better shrinking tumors while fitting the treatment to the tumor’s exact location.
ErlangenAges 18 years+ - NCT03787056Recruiting
Blood test marker study in many cancer types
This study measures a blood marker called progastrin (at diagnosis and during treatment) to see how well it predicts response or outcomes. It may help doctors choose or monitor treatment more precisely for several cancer types.
BronAges 18 years+ - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT04470024RecruitingPhase 1
Testing a vaccine plus immunotherapy for recurrent head and neck cancer
This early-phase (Phase 1b) study tests a vaccine designed to train the immune system to fight head and neck squamous cell carcinoma, plus standard immunotherapy. It may help some people by boosting the body’s anti-cancer immune response, but it mainly focuses on safety and finding the best approach.
Portland, OregonAges 18 years+ - NCT04593589RecruitingPhase 1
Stem cell transplant to protect salivary function after oral cancer
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
GroningenAges 18 years+ - NCT04767048RecruitingPhase 2
Robot or laser tongue scraping plus tonsil removal to assess lymph nodes
This trial looks at whether a more precise procedure—removing a small area of tongue lining using a robot or laser, along with tonsil removal—can find the likely source of stubborn swollen neck lymph nodes. It’s designed for people with signs of head-and-neck cancer in lymph nodes, but no clear primary tumor found yet.
CaenAges 18 years+ - NCT04842162RecruitingPhase 2
Near-infrared dye imaging to help remove all mouth/throat cancer
This Phase 2 study tests a special camera and dye during surgery to help surgeons confirm they removed all cancer at the edge of the removed tissue. If it works, it may lower the chance of cancer being left behind after oral cavity or oropharynx squamous cell cancer surgery.
AnderlechtAges 18 years+ - NCT04916990Recruiting
Care program for rural adults with several lung and head cancers
This study looks at how to improve care for adults with certain cancers who live in rural areas and may face access problems. It mainly focuses on people receiving cancer treatment at specific Colorado-area hospitals, and who are uninsured or underinsured.
Aurora, ColoradoAges 18–99 - NCT04930432RecruitingPhase 1/Phase 2
MCLA-129 for advanced EGFR- and MET-positive lung and other cancers
This early-phase trial tests MCLA-129, an antibody that targets EGFR and MET, in people with advanced cancers that have specific lab “biomarker” results. It’s for patients whose cancer has grown after standard treatments or can’t take standard treatment, with the goal of shrinking tumors and improving symptoms.
BaodingAges 18 years+ - NCT05082961Recruiting
Blood immune markers and brain radiation after head/neck surgery
This study looks at immune system signals in your blood during and after postoperative radiation therapy for certain head and neck cancers involving the brain or skull base. Researchers want to see whether these “immune markers” relate to treatment response or side effects.
CaenAges 18 years+ - NCT05260671RecruitingPhase 2
Penpulimab plus cetuximab for advanced head and neck cancer
This trial studies penpulimab (an immune medicine) combined with cetuximab (an antibody drug) for recurrent or metastatic squamous cell head and neck cancer that cannot be treated with surgery or radiation. It aims to shrink tumors and improve survival in people whose tumor shows a specific immune marker (PD-L1).
Changchun, JilinAges 18–80 - NCT05313191Recruiting
Proton therapy for tumors after prior radiation
This study looks at whether a type of proton beam treatment can be given safely and effectively to tumors that have already been treated with radiation before. It may help people whose tumors came back or persisted after earlier radiation, using a specific proton method called pencil beam scanning.
New York, New YorkAges 18 years+ - NCT05319483Recruiting
Study of new head and neck cancer patients
This study enrolls adults with a first-time head and neck cancer diagnosis and collects health and treatment information to better understand the disease. It may help clinicians improve care by learning which treatments and patient features matter most.
Pécs, BaranyaAges Any age - NCT05358548RecruitingPhase 2
Alternating treatment for advanced lung and head-neck cancers
This Phase 2 study tests an approach that alternates treatments for advanced lung cancer or recurrent/metastatic head and neck squamous cell cancer. It may help by improving how well the cancer responds while managing side effects differently than standard back-to-back therapy.
Elizabeth, New JerseyAges 18 years+ - NCT05379712RecruitingPhase 2
Nutrition supplements during radiation for head and neck cancer
This trial studies whether a nutritional supplement helps people with head and neck squamous cell cancer when they are receiving radiation (with or without chemotherapy). You must be able to eat by mouth and have specific cancer types and recent CT imaging.
Edmonton, AlbertaAges 18 years+ - NCT05483400RecruitingPhase 2
Atezolizumab and tiragolumab study for several solid tumors
This Phase 2 trial tests the cancer medicines atezolizumab and tiragolumab in people with different solid tumors. It aims to see how well these drugs work and what side effects they cause in specific patient groups.
GroningenAges 18 years+ - NCT05757817Recruiting
New flap surgery for mouth or throat cancer reconstruction
This trial studies whether a new surgical reconstruction method can improve outcomes for people with oral cavity or oropharyngeal squamous cell carcinoma (a type of head and neck cancer). The goal is to rebuild the area using a tissue flap while reducing problems where the tissue is taken from.
MontpellierAges 18 years+ - NCT05777824RecruitingPhase 2
Testing treatment after head and neck cancer response to chemo-immunotherapy
This Phase 2 study looks at what treatment is best after you first receive chemotherapy plus immunotherapy, then have surgery for head and neck squamous cell cancer. It tries to use how your tumor responds (shown in lab tissue after treatment) to guide the next steps, which may improve outcomes.
Beijin, Beijing MunicipalityAges 18–75 - NCT05944237RecruitingPhase 1/Phase 2
Early trial for advanced cancers using HTL0039732
This is a Phase 1/2 study testing how well HTL0039732 works and is tolerated in people with advanced solid tumors that have not responded to standard treatments. It may help by offering a new treatment option and learning which cancer types and body markers respond best.
CambridgeAges 18 years+
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Common questions
- Are there clinical trials for head and neck carcinoma?
- Yes. Clin2 currently lists 504 recruiting head and neck carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Head and Neck Cancer Squamous Cell Carcinoma
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Resectable Head and Neck Squamous Cell Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.