Clinical trials
Head and Neck Carcinoma clinical trials
Below are recruiting head and neck carcinoma clinical trials, each written for real people, not researchers. We’re tracking 503 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07173270Recruiting
Improving oral health in head and neck cancer survivors
This trial aims to improve oral health in people being treated for head and neck cancer. If you are receiving radiation therapy, this study may help manage side effects and keep your mouth healthier.
UppsalaAges 18 years+ - NCT07156227RecruitingPhase 1
Testing camonsertib with radiation for returning head and neck cancer
This study tests whether adding the drug camonsertib to radiation therapy can help people whose head and neck cancer has come back in a spot that was already treated with radiation. Camonsertib is an experimental drug that may help radiation work better.
Duarte, CaliforniaAges 18 years+ - NCT05621837Recruiting
Biomarker study to guide treatment for several advanced cancers
This study measures how strongly your immune system is being suppressed and uses that information to help personalize cancer treatment. It mainly looks at people with certain advanced cancers and needs tumor tissue and follow-up to check possible immune-related markers.
MilanAges 18–90 - NCT07147426RecruitingPhase 2
Tislelizumab plus chemo before surgery for head and neck cancer
This trial tests whether giving the immunotherapy drug tislelizumab with chemotherapy before surgery can help people with advanced head and neck cancer. The goal is to shrink the tumor enough to remove it completely during surgery.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07149207RecruitingPhase 2
Using a dye during head and neck cancer surgery
This study tests whether a special dye (ICG) injected before surgery can help surgeons see head and neck cancer more clearly during the operation. It is for people with squamous cell carcinoma who are at risk of their cancer returning and are scheduled for surgery.
Charleston, South CarolinaAges 18 years+ - NCT06540443RecruitingPhase 1
Enhanced MRI for staging head and neck cancer
This trial tests a new imaging agent (MPB-2043) that may help doctors see cancer spread to lymph nodes more clearly during an MRI scan. It is for people with head and neck cancer who are planning to have lymph node surgery.
TaipeiAges 20 years+ - NCT03406247RecruitingPhase 2
Immunotherapy after salvage surgery for head and neck cancer
This Phase 2 trial tests an immunotherapy given after salvage surgery for certain head and neck squamous cell cancers that came back (or a new second cancer) in an area that was already treated with radiation. It aims to lower the chance the cancer returns after surgery, especially in higher-risk situations.
Villejuif, Val De MarneAges 18 years+ - NCT07131566Recruiting
Immune response in neck lymph nodes in head and neck cancer
This study looks at how the immune system in the lymph nodes of the neck responds to head and neck cancer. It will help researchers understand how the body fights these cancers, which could lead to better treatments.
Stockholm, Stockholm CountyAges 18 years+ - NCT07125755RecruitingPhase 3
Comparing Chemo plus Radiation vs. Radiation Alone for Head and Neck Cancer
This trial tests whether adding chemotherapy to radiation therapy after surgery can help prevent head and neck cancer from coming back. It is for people who have certain risk factors after their surgery but no signs of cancer spread.
Guangzhou, GuangdongAges 18–70 - NCT07109726RecruitingPhase 1/Phase 2
Testing TER-2013 for advanced tumors with AKT/PI3K/PTEN changes
This trial tests a new drug called TER-2013, alone or combined with another drug (fulvestrant), for people with advanced solid tumors that have specific genetic changes in the AKT/PI3K/PTEN pathway. It aims to see if the drug is safe and effective.
Duarte, CaliforniaAges 18 years+ - NCT07105592RecruitingPhase 1/Phase 2
Study of nimotuzumab plus adebrelimab with chemo for head and neck cancer patients who cannot take cisplatin
This trial tests a combination of two drugs (nimotuzumab and adebrelimab) along with chemotherapy for people with head and neck cancer that has returned or spread, and who cannot take the standard chemo drug cisplatin. The goal is to see if this combination works and is safe for these patients.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07090499RecruitingPhase 1
Study of PF-08046876 for advanced solid tumors
This trial tests a new medicine, PF-08046876, for people with advanced cancers of the bladder, lung, head and neck, esophagus, or pancreas. It aims to see if the drug is safe and works against these cancers.
Duarte, CaliforniaAges 18 years+ - NCT07094685RecruitingPhase 2
Ivonescimab before surgery for head and neck cancer
This study tests a new immunotherapy drug called ivonescimab given before surgery for people with advanced head and neck cancer. The goal is to see if it helps shrink the tumor and improve outcomes.
Ann Arbor, MichiganAges 18 years+ - NCT06744296Recruiting
ctDNA surveillance for HPV-negative head and neck cancer
This trial uses a blood test to look for tiny bits of tumor DNA after treatment for head and neck cancer. It aims to see if this test can detect any remaining cancer cells early, so you and your doctor can make informed decisions.
Boston, MassachusettsAges 18 years+ - NCT07070518RecruitingPhase 1/Phase 2
Study of GV20-0251 for advanced solid tumors
This trial tests a new study drug, GV20-0251, for people with advanced solid tumors that no longer respond to standard therapies. It aims to see if the drug can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07062354Enrolling by invitationPhase 2
Study of amivantamab plus chemo for head and neck cancer
This trial tests a new drug (amivantamab) combined with two chemotherapy drugs (carboplatin and paclitaxel) for people with head and neck cancer that has spread or come back after treatment and cannot be removed by surgery. This study aims to see if this combination can help shrink tumors.
Tucson, ArizonaAges 18 years+ - NCT07059221RecruitingPhase 1/Phase 2
New drug combo for advanced head and neck cancer
This trial tests a new combination of drugs (SHR-A2102 and Adebrelimab) with or without other anti-cancer therapies for head and neck cancer that has come back or spread. It aims to see if these treatments can shrink tumors or slow the disease.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07058116RecruitingPhase 1
BNCT radiation therapy for head and neck cancer
This trial tests a type of radiation therapy called BNCT (boron neutron capture therapy) for people with head and neck cancer that cannot be surgically removed. It may be an option if you have already had radiation or chemo and have no distant spread of cancer.
HelsinkiAges 18 years+ - NCT07055841RecruitingPhase 2
Study of PD-L1 antibody plus chemo before surgery for head and neck cancer
This trial tests whether adding a PD-L1 antibody (Adabelimab) to standard chemotherapy before surgery can help treat advanced head and neck squamous cell carcinoma. It is for people who have not had treatment for this cancer before and are well enough to undergo the therapy.
Jinan, ShandongAges 18–85 - NCT07063212RecruitingPhase 2
Sacituzumab govitecan plus cetuximab for head and neck cancer
This trial tests a combination of two drugs—sacituzumab govitecan and cetuximab—for people with advanced head and neck cancer that has gotten worse after immunotherapy. The goal is to see if this new treatment can shrink or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT07058805RecruitingPhase 2
Radiation therapy after surgery for head and neck cancer
This trial tests whether giving radiation therapy in a specific way (compartmentalized) after surgery for head and neck cancer is safe and effective. It is for people with certain types of head and neck cancer that have been removed, and aims to improve outcomes while managing side effects.
BaselAges 18 years+ - NCT06997094RecruitingPhase 1
Decitabine plus standard therapy for HPV-negative head and neck cancer
This trial tests whether adding the drug decitabine to standard treatment (surgery and possibly radiation) can help people with a type of head and neck cancer not caused by HPV. You would receive decitabine before surgery, and then continue with standard care after.
Jacksonville, FloridaAges 18 years+ - NCT06995508RecruitingPhase 2
Olanzapine for appetite loss in head and neck cancer patients
This trial tests if the drug olanzapine can help improve appetite in people with head and neck cancer who are getting chemotherapy and radiation. It aims to prevent or reduce weight loss during treatment.
Buffalo, New YorkAges 18 years+ - NCT06997068RecruitingPhase 2
Drug combination for returning head and neck cancer
This trial tests a combination of three drugs—methotrexate, erlotinib, and celecoxib—for people whose head and neck cancer has come back or spread. It is designed for patients in the rural Midwest who have already had or chosen not to have standard first treatment.
Rochester, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for head and neck carcinoma?
- Yes. Clin2 currently lists 503 recruiting head and neck carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Head and Neck Cancer Squamous Cell Carcinoma
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Resectable Head and Neck Squamous Cell Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.