Clinical trials
Head and Neck Squamous Cell Cancer clinical trials
Below are recruiting head and neck squamous cell cancer clinical trials, each written for real people, not researchers. We’re tracking 439 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07812805RecruitingPhase 1
New targeted treatment with imaging for advanced solid tumors
This trial tests a new experimental treatment (SKL35501) that uses a special imaging agent (SKL35502) to find and target a marker called NTSR1 found on some advanced cancers. The goal is to see if this treatment is safe and can help people whose cancer has stopped responding to standard treatments.
Glen Burnie, MarylandAges 18 years+ - NCT07814248RecruitingPhase 1
TS-104 for advanced solid tumors
This trial tests a new drug called TS-104 for people with certain advanced solid tumors that have stopped responding to standard treatments. The drug is given alone (not with other cancer treatments) to see if it can shrink tumors or slow their growth.
Maumee, OhioAges 18 years+ - NCT07807163RecruitingPhase 2
Study of ficerafusp alfa with pembrolizumab for head and neck cancer
This study tests a new drug called ficerafusp alfa combined with pembrolizumab (an immunotherapy) in people with head and neck cancer that has returned or spread. The drug targets a protein that may help the immune system fight the cancer. The study is comparing two different schedules of giving the drug to see which is better.
Fort Myers, FloridaAges 18 years+ - NCT06534762RecruitingPhase 2
Miraberon for advanced solid tumors (first treatment)
This study tests a drug called Miraberon for people with advanced solid tumors that have not yet been treated with chemotherapy or other cancer drugs. The goal is to see if Miraberon can help shrink or control the cancer.
Hangzhou, ZhejiangAges 18–65 - NCT07791745RecruitingPhase 2/Phase 3
Comparing treatments for advanced head and neck cancer
This trial tests a new combination of treatments for head and neck cancer that has returned or spread and can't be cured with local therapy. It compares a standard chemotherapy with or without an additional drug to see which is more effective and safe.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05933889Recruiting
Study of robotic throat surgery for early oropharyngeal cancer
This study looks at how well different robotic surgery approaches work for people with early oropharyngeal squamous cell carcinoma (throat cancer). You may be asked for consent for extra tissue and imaging analysis to help researchers understand patterns related to outcomes.
LondonAges 18 years+ - NCT06100497RecruitingPhase 2
PD-1 plus chemo for advanced head and neck cancer
This trial tests a combination of immunotherapy (PD-1) and chemotherapy for people with advanced head and neck cancers that are poorly differentiated. The goal is to see if the combination helps shrink tumors before possible surgery or radiation.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07770100RecruitingPhase 2
Matching immunotherapy and targeted radiation for advanced cancer
This trial tests combining immunotherapy (a treatment that boosts your immune system to fight cancer) with a targeted type of radiation called SBRT, which precisely delivers high-dose radiation to multiple cancer spots. The main goal is to see if this combination helps control metastatic cancer (cancer that has spread) better than standard care.
Lexington, KentuckyAges 18–99 - NCT06572514RecruitingPhase 1/Phase 2
Lower radiation after chemo-immunotherapy for head and neck cancer
This trial tests if giving less radiation than usual is safe and effective for certain head and neck cancers after initial treatment with chemotherapy and immunotherapy. It aims to reduce side effects while still controlling the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07766226Recruiting
Online support group for head and neck cancer patients
This study tests whether an online support group can help people with head and neck cancer feel better during and after their radiation treatment. You would participate in a shared online community and complete questionnaires about your well-being.
Chengdu, SichuanAges 18–75 - NCT06248996RecruitingPhase 3
Testing a stronger radiation schedule for large head and neck cancers
This trial tests whether giving a slightly different schedule of radiation (more frequent, smaller doses) can improve treatment for people with large head and neck cancers. It is for patients who are getting radiation as their main treatment, sometimes with chemotherapy as well.
GävleAges 18–100 - NCT07755449RecruitingPhase 2
Targeted radiation for head and neck cancer after surgery
This trial tests a new way of giving radiation therapy only to the side of the neck that needs it, which may reduce side effects while still preventing cancer from coming back. It is for people who have had surgery for head and neck cancer and have not had the cancer spread to the lymph nodes.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06137378RecruitingPhase 2
Pembrolizumab for advanced throat cancer to avoid laryngectomy
This trial tests whether a drug called pembrolizumab (Keytruda) can help people with advanced throat cancer avoid removal of the voice box. You may be eligible if you have a specific type of larynx or hypopharynx cancer that hasn't been treated with radiation or immunotherapy before.
Mannheim, Baden-WürtembergAges 18–70 - NCT05996432RecruitingEarly Phase 1
Using imaging to guide radiation therapy for head and neck cancer or brain tumors
This trial uses a special PET scan tracer called 18F-FMISO to see areas of low oxygen (hypoxia) in your tumor. The results may help doctors adjust your radiation plan to target those areas more precisely.
Nashville, TennesseeAges 18 years+ - NCT07726199Recruiting
Neck treatment approaches for oral cancer without neck spread
This study compares different ways to treat the neck in patients with early-stage oral cancer that hasn't spread to the neck. The goal is to find which approach works best while keeping side effects low.
Kolhāpur, MaharashtraAges 21–75 - NCT07717307Recruiting
Comparing two neck surgeries for oral cancer spread
This trial tests whether a smaller neck surgery works as well as a larger one for people with oral cancer that has spread to one lymph node. The goal is to see if less extensive surgery can reduce side effects while still controlling the cancer.
Kolhāpur, MaharashtraAges 21–75 - NCT05286619RecruitingPhase 2
Pembrolizumab with chemotherapy for recurrent head and neck cancer
This trial studies whether pembrolizumab plus chemotherapy (platinum and gemcitabine) can control recurrent or metastatic head and neck squamous cell carcinoma that can’t be cured with local treatments. It may help shrink tumors and slow disease growth in people who haven’t had cancer medicines for this stage before.
Kuala LumpurAges 18 years+ - NCT04593589RecruitingPhase 1
Stem cell transplant to protect salivary function after oral cancer
This Phase 1 study tests whether transplanting stem cells into the submandibular gland can help restore saliva function after surgery and radiation for oral cavity squamous cell cancer. You may be considered because you recently had tumor removal and radiation aimed at the neck area, which can damage salivary glands.
GroningenAges 18 years+ - NCT07690618RecruitingPhase 1
Heat therapy for head and neck cancer
This phase 1 trial tests adding heat therapy (thermotherapy) to standard radiation (with or without chemo) for head and neck cancer. It aims to see if it is safe and effective for patients with locally advanced disease who have not had radiation before.
Rotterdam, South HollandAges 18 years+ - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT07672236RecruitingPhase 3
Comparing two mouth pain treatments for head and neck cancer patients
This trial tests a new mouthwash (BupiZenge) against a standard numbing medicine (lidocaine) for pain caused by mouth sores from radiation therapy. It may help you if you are about to start radiation for certain head and neck cancers.
CopenhagenAges 18–80 - NCT07662681RecruitingPhase 1/Phase 2
Camrelizumab plus famitinib for rare head and neck cancers
This trial tests a combination of two drugs—camrelizumab (an immunotherapy) and famitinib (a targeted therapy)—for people with rare head and neck tumors that cannot be removed by surgery or have spread. It may be an option if you have not had a prior PD-1 inhibitor and have had at most one prior systemic treatment.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07659678RecruitingPhase 2
Pet scan for head and neck cancer
This study tests a special PET/CT scan that may help doctors see the cancer more clearly in people with head and neck cancer, either at diagnosis or if it comes back.
St Louis, MissouriAges 18 years+ - NCT07662746RecruitingPhase 2
Paclitaxel micelles for advanced head and neck cancer
This trial tests a new form of chemotherapy called paclitaxel polymeric micelles for people with head and neck cancer that has come back or spread. It is for patients who have already tried one line of treatment and may benefit from a different option.
Shanghai, Shanghai MunicipalityAges 18–75
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Common questions
- Are there clinical trials for head and neck squamous cell cancer?
- Yes. Clin2 currently lists 439 recruiting head and neck squamous cell cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck squamous cell cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck squamous cell cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Head and Neck Cancer Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Head and Neck Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Resectable Head and Neck Squamous Cell Carcinoma
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.