Clinical trials
Head and Neck Squamous Cell Carcinoma clinical trials
Below are recruiting head and neck squamous cell carcinoma clinical trials, each written for real people, not researchers. We’re tracking 484 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07217028RecruitingPhase 1
Safety study of a new PET tracer for head and neck cancer
This study tests a new radioactive tracer called [18F]NOTA-ABY030 to see if it's safe for people with head and neck cancer that may have spread. The tracer lights up cancer cells on a PET scan, helping doctors find tumors more clearly.
Nashville, TennesseeAges 18 years+ - NCT07232524RecruitingPhase 1
BL-M24D1 for advanced head and neck and other solid tumors
This study tests a new drug called BL-M24D1 in people with head and neck cancer or other solid tumors that have spread or cannot be surgically removed. The goal is to see if the drug is safe and can help shrink tumors.
Chengdu, SichuanAges 18 years+ - NCT07242859Recruiting
Rice bran for mouth sores from radiation in head and neck cancer
This trial tests whether a rice bran supplement can help prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you're getting radiation with or without chemo, this simple addition might ease side effects.
CairoAges 18 years+ - NCT07253402Recruiting
Microbiota-guided radiation therapy for head and neck cancer
This trial is testing a new way to use radiation therapy for head and neck cancer by also looking at the bacteria in your mouth and gut. The goal is to see if adjusting the treatment based on your bacteria can improve outcomes and reduce side effects.
Milan, MilanAges 18 years+ - NCT07254585RecruitingPhase 2
SYS6010 plus enlonstobart for head and neck cancer
This trial is testing a new combination treatment, SYS6010 plus enlonstobart, for people with head and neck squamous cell carcinoma that has come back or spread. It aims to see if this combination works better than enlonstobart alone.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07264075RecruitingPhase 3
Ivonescimab with or without ligufalimab vs pembrolizumab for head and neck cancer
This trial tests a new immunotherapy combination (ivonescimab alone or with ligufalimab) against the standard immunotherapy pembrolizumab (Keytruda) for people with head and neck cancer that has come back or spread. It may be an option if you have not had any prior immunotherapy and your tumor is PD-L1 positive.
Le HavreAges 18–80 - NCT07274852RecruitingPhase 1
Study of a radioactive drug for advanced solid tumors
This trial tests a new radioactive drug (177Lu-BL-ARC001) for people with advanced lung, breast, head and neck, or other solid tumors that have not responded to standard treatments. It aims to see if the drug can target and shrink tumors while limiting side effects.
Chengdu, SichuanAges 18 years+ - NCT07285044RecruitingPhase 2
Home cancer treatment program for Florida panhandle residents
This study tests whether people with certain cancers can safely receive their regular intravenous treatments at home instead of coming to the clinic. It aims to make treatment more convenient and improve satisfaction, especially for those living in the Florida Panhandle.
Jacksonville, FloridaAges 18 years+ - NCT07333274RecruitingPhase 3
Radiation plus nimotuzumab for head and neck cancer
This trial compares radiation therapy alone versus radiation therapy plus a targeted drug called nimotuzumab for people with advanced head and neck cancer who cannot take cisplatin chemotherapy. The goal is to see if adding nimotuzumab improves outcomes.
Shandong, ProvinceAges 18 years+ - NCT00568490Recruiting
Finding blood markers that show low oxygen in tumors
This study looks for substances in blood that may reflect how “low-oxygen” a tumor is. If you have head and neck cancer or non-small cell lung cancer, it may help researchers understand tumor oxygen levels and improve future care.
Stanford, CaliforniaAges 18 years+ - NCT07348211RecruitingPhase 1
Study of SIM0610 for advanced solid tumors
This trial tests a new drug called SIM0610 for people with advanced solid tumors that have stopped responding to standard treatments. The study aims to see if the drug is safe and effective.
Chongqing, Chongqing MunicipalityAges 18 years+ - NCT07369882Recruiting
Less extensive surgery after immunotherapy for advanced head and neck cancer
This trial compares a less extensive surgery to the standard surgery for patients with advanced head and neck cancer who have responded well to initial chemotherapy and immunotherapy. The goal is to see if a smaller operation can be just as effective while causing fewer side effects.
Guangzhou, GuangdongAges 18–75 - NCT07371611RecruitingPhase 3
Sintilimab plus chemo before and after surgery for advanced oral cancer
This trial tests whether adding an immunotherapy drug (sintilimab) to standard chemotherapy before and after surgery can improve outcomes for people with advanced oral squamous cell carcinoma. The treatment is given first to shrink the tumor, then again after surgery to help prevent recurrence.
Guangzhou, GuangdongAges 18–75 - NCT07390838RecruitingPhase 1
Study of SH009 for advanced solid tumors
This trial tests an investigational drug called SH009 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective.
ShanghaiAges 18 years+ - NCT01473784Recruiting
Robot-assisted mouth and throat surgery for head and neck tumors
This trial studies using a robot-assisted operation through the mouth to diagnose or treat certain non-cancer (benign) and cancer (malignant) tumors in the head and neck. It may help some people avoid more invasive surgery by using an approach that reaches the throat and voice box area through the mouth.
Columbus, OhioAges 18 years+ - NCT02139020Recruiting
Plasma sample collection for head and neck squamous cancer
This study collects blood plasma samples from people with squamous cell cancer of the head and neck. Researchers want to better understand how treatments work, based on your prior cancer therapy, which may help future care.
Ottignies, Brabant WallonAges 18 years+ - NCT02678884Recruiting
PET-CT scan study for head and neck cancer before radiotherapy
This study uses PET-CT scans (a type of imaging that highlights active cancer cells) in people with a specific kind of head and neck cancer. The goal is to see how well the first scan identifies tumors that should be checked again with a second scan, to better guide care with radiotherapy.
Toronto, OntarioAges 18 years+ - NCT02572778Recruiting
Study using patient tumor samples in head and neck cancer
This study uses tumor tissue taken from people with head and neck cancer, then grows it in a lab to better understand the cancer and predict responses. If you have a new or returning cancer and can share key medical details and follow-up information, you may be able to take part.
BrusselsAges 18 years+ - NCT07059221RecruitingPhase 1/Phase 2
New drug combo for advanced head and neck cancer
This trial tests a new combination of drugs (SHR-A2102 and Adebrelimab) with or without other anti-cancer therapies for head and neck cancer that has come back or spread. It aims to see if these treatments can shrink tumors or slow the disease.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07513389RecruitingPhase 2
HPV throat cancer trial skipping radiation with blood tests
This study tests whether patients with a specific type of HPV-positive throat cancer can safely skip radiation after surgery by using blood tests to monitor for cancer recurrence. The goal is to reduce side effects while keeping patients cancer-free.
Charleston, South CarolinaAges 18 years+ - NCT07402525Recruiting
Radiation after surgery for early-stage tongue cancer with risk factors
This trial tests whether adding radiation therapy after surgery helps prevent the return of early-stage tongue cancer in patients who have certain risk factors, such as nerve invasion or poorly differentiated cells. It is for people whose cancer was limited to the front two-thirds of the tongue and was completely removed.
Bengbu, AnhuiAges 18–70 - NCT07405086RecruitingPhase 4
Morning vs. afternoon immunotherapy for advanced solid tumors
This trial compares giving immunotherapy in the morning versus the afternoon to see if timing affects how well it works. It is for people with certain types of advanced or metastatic solid tumors who have not had this treatment before.
Portland, OregonAges 18 years+ - NCT07405645Recruiting
Focused Ultrasound for Cancer Pain in the Head or Neck
This trial tests a non-invasive focused ultrasound treatment aimed at a specific brain area to reduce severe cancer-related pain in the head, neck, or upper chest. It may help if your pain hasn't responded to standard medications.
Boston, MassachusettsAges 18–85 - NCT07408063RecruitingPhase 2
Study of new drug for advanced head and neck cancer
This trial tests a new drug (GSK5764227) for head and neck cancer that has spread or come back. It looks at your tumor's biomarkers to understand why some people respond to treatment. You may need to have had certain prior treatments depending on which group you join.
Toronto, OntarioAges 18 years+
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Common questions
- Are there clinical trials for head and neck squamous cell carcinoma?
- Yes. Clin2 currently lists 484 recruiting head and neck squamous cell carcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a head and neck squamous cell carcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a head and neck squamous cell carcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Recurrent Head and Neck Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Locally Advanced Head and Neck Squamous Cell Carcinoma
- Head and Neck Cancer Squamous Cell Carcinoma
- Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
- Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
- Resectable Head and Neck Squamous Cell Carcinoma
- Cutaneous Squamous Cell Carcinoma of the Head and Neck
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.