Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT01607502Recruiting
Database study for people with pulmonary hypertension symptoms
This study builds a medical and symptom database for people who have pulmonary hypertension or may be at risk, to better understand the condition. If you choose to participate, your basic health information and symptom history may be recorded and used for research.
GrazAges 18 years+ - NCT01712620RecruitingPhase 2
Spironolactone for pulmonary arterial hypertension in stable patients
This trial studies whether spironolactone can improve pulmonary arterial hypertension, a disease that makes the blood vessels in the lungs work too hard. You may be eligible if your condition is confirmed by specific heart-lung pressure tests and your medication plan has been stable for at least 4 weeks.
Bethesda, MarylandAges 18–100 - NCT01730092Recruiting
Study of blood and imaging biomarkers in pulmonary artery hypertension
This study tracks natural changes in “biomarkers” (measurable signals in blood) and imaging findings in people with pulmonary arterial hypertension (PAH) or suspected PAH. It also includes healthy people for comparison, helping researchers understand what these signals mean over time.
Bethesda, MarylandAges 18–100 - NCT01347216Recruiting
COMPERA study for lung vessel pressure medicines
This study follows people with different types of high blood pressure in the lungs (pulmonary hypertension) to see how starting specific lung blood vessel medicines affects outcomes. It may help improve how clinicians choose and monitor treatment over time.
LeuvenAges 1 week+ - NCT02417740Recruiting
Study of the natural course of noncirrhotic portal hypertension
This study follows people with noncirrhotic portal hypertension (NCPH) or people at risk for it to better understand how the condition progresses over time. It does not sound like a medication trial—more like careful monitoring to learn what happens in different people.
Bethesda, MarylandAges 12–100 - NCT02770066Recruiting
Registry study of PTRA in difficult-to-control blood pressure
This study keeps track of people with renovascular hypertension (high blood pressure likely linked to blocked kidney arteries) who may receive a procedure called PTRA. It aims to understand who benefits and how kidney and heart outcomes change over time.
AalborgAges Any age - NCT02608996RecruitingPhase 1/Phase 2
Nesiritide test for hard-to-control blood pressure
This Phase 1/2 study tests nesiritide, a medicine that affects blood vessels and heart strain, to see if it can improve blood pressure control in people with hypertension. It’s mainly for people whose blood pressure stays high even during the day despite medication.
OsloAges 18–79 - NCT02249923Recruiting
Children with pulmonary hypertension registry in Spanish or English
This registry study collects information from children and families affected by pulmonary hypertension to better understand the condition. It may help researchers track outcomes over time and improve future care.
Palo Alto, CaliforniaAges 1 day–21 years - NCT02691689Recruiting
Genetics study in families with congenital heart defects and PAH
This study looks at genes that may contribute to pulmonary arterial hypertension (PAH) in people born with certain heart “shunts” (holes between heart chambers). If you have (or your family has) ASD or VSD and PAH confirmed by a heart pressure test, you may be invited to share genetic and health information to help researchers understand risk and better target future care.
LeuvenAges 18 years+ - NCT02804074Recruiting
Treat “hidden” high blood pressure using 24-hour monitoring
This study looks at better treatment for people whose blood pressure looks okay in the clinic, but stays high during daily life or at night. It uses 24-hour blood pressure monitoring (a test that checks readings throughout the day) to guide care and see if it helps control “masked uncontrolled” hypertension.
MilanAges 35–80 - NCT07115953Recruiting
Spiral nerve treatment for uncontrolled high blood pressure
This trial tests a new procedure to treat high blood pressure by using a special catheter to calm overactive nerves in your kidneys. It may help you achieve better blood pressure control if medications are not enough.
MelbourneAges 18 years+ - NCT07075588Recruiting
Food and coaching to lower blood pressure for Black and Hispanic adults
This study tests a program that helps people manage their blood pressure by offering healthy food choices, personal diet coaching, and text messages that match your culture. It's for Black/African American or Hispanic/Latino adults living in certain low-income areas of Maryland.
Baltimore, MarylandAges 21–70 - NCT01725763Enrolling by invitation
MRI without contrast to help diagnose pulmonary hypertension
This study uses an MRI scan that does not use contrast dye to better diagnose and sort out pulmonary hypertension (high blood pressure in the lungs). It may help doctors classify your condition more accurately, especially around the time you’re scheduled for a right-heart catheterization.
Graz, StyriaAges 18 years+ - NCT01571700Enrolling by invitation
Study breathing-heart timing differences in pulmonary hypertension
This study looks at timing mismatches (“dysynchrony”) in the heart and lungs in people with pulmonary hypertension. It may help researchers understand what causes symptoms and how the timing affects heart function.
Stanford, CaliforniaAges 5 years+ - NCT07400549Recruiting
Exercise plan study for people with high blood pressure, blood sugar, cholesterol, or uric acid
This study tests a tool that helps doctors create personalized exercise plans for people with conditions like high blood pressure, diabetes, high cholesterol, or high uric acid (the "Four Highs"). It could help you stay active and manage your health better.
BeijingAges 18 years+ - NCT07419724Recruiting
Portal hypertension biobank study
This study collects medical data and images from people with portal hypertension who have enlarged veins in the esophagus or stomach. It aims to build a database for future research.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07424963Recruiting
Comparing two ways to measure liver pressure
This study compares a newer, less invasive method using an endoscope (EUS-PPG) with a standard catheter method (HVPG) to measure liver pressure in people with advanced liver disease. The goal is to see if the newer method is equally accurate and safer.
Prague, BohemiaAges 18–75 - NCT07448818Recruiting
Strength training for older adults with high blood pressure
This study tests whether different types of strength training (dynamic and isometric) can help older adults with high blood pressure who are already taking medication. It's designed for people who are not very active and have no major health risks.
São Paulo, São PauloAges 60 years+ - NCT07453017Recruiting
Electrical impedance tomography for pulmonary hypertension
This study tests a new, noninvasive way to measure lung function in people with pulmonary hypertension (high blood pressure in the lungs). It uses a belt with electrodes placed around your chest during a standard heart catheterization procedure.
São Paulo, São PauloAges 18 years+ - NCT07453550Recruiting
Exercise and Blood Pressure Study
This study tests whether short periods of exercise can lower blood pressure. It is for adults with slightly elevated blood pressure who are not on medication and do not smoke or have certain health conditions.
West Hartford, ConnecticutAges 18–55 - NCT07457762Recruiting
Reminder app for pulmonary hypertension inhaler
This study tests if a smartphone app can help people with pulmonary arterial hypertension (PAH) stick to their inhaled iloprost treatment. It is for adults already on this treatment at a specific clinic in Brazil.
São Paulo, São PauloAges 18 years+ - NCT07457970Recruiting
Health coaching to lower heart risk for women after pregnancy high blood pressure
This trial tests whether a community health worker can coach women who had high blood pressure during pregnancy to lower their future heart disease risk. It starts during pregnancy and continues after delivery.
Columbia, South CarolinaAges 18 years+ - NCT07461415Recruiting
Telehealth coaching for high-risk hypertension
This trial tests whether community health workers can help people with very high blood pressure manage it better through phone calls and home visits. It may help you if you have had a dangerously high blood pressure reading in the emergency room but do not have serious organ damage.
Karachi, SindhAges 18 years+ - NCT07462260RecruitingPhase 2/Phase 3
Sildenafil for severe pulmonary hypertension from rheumatic valve disease
This trial tests if sildenafil can help people with severe pulmonary hypertension caused by rheumatic valvular heart disease. It aims to see if the drug improves symptoms and heart function.
Hyderābād, SindhAges 18 years+
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Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 984 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.