Clinical trials
High blood pressure clinical trials
Persistently raised blood pressure, a major risk factor for heart disease and stroke. We’re tracking 984 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06500351Recruiting
Postpartum hypertension gene and aging study
This study looks at two things in women with postpartum hypertension (high blood pressure after giving birth). It tests a gene called Renalase and measures the length of telomeres (a marker of cell aging) to see if they are linked to this condition.
SohagAges 18–45 - NCT06343298RecruitingPhase 2
Testing MANP for hard-to-control high blood pressure
This trial tests a new drug called MANP for people whose blood pressure stays high despite taking three or more different types of blood pressure medications. The goal is to see if MANP is safe and effective in lowering blood pressure.
Little Rock, ArkansasAges 18–80 - NCT05311072Recruiting
Update a CTEPH patient database in China
This study helps doctors update and improve how they understand chronic thromboembolic pulmonary hypertension (CTEPH) in patients in China. It likely involves sharing your medical information (not a new drug) and confirming your diagnosis details to support future research.
BeijingAges 14 years+ - NCT06246396RecruitingPhase 4
Minocycline for resistant high blood pressure
This study tests whether minocycline, a common antibiotic, can help lower blood pressure in people whose high blood pressure is not controlled by multiple medications. If you have resistant hypertension, this trial may offer a new option to better manage your condition.
Gainesville, FloridaAges 18–100 - NCT06524440Recruiting
Hypertensive heart disease study in DR Congo
This trial studies people with hypertensive heart disease in DR Congo. It aims to learn more about the condition.
KinshasaAges 18 years+ - NCT07548567Recruiting
Nerve Block to Reduce Pain During Below-Knee Fracture Surgery
This study tests a nerve-blocking injection (numbing medicine around the femoral artery nerve in your groin area) to help reduce pain and blood pressure changes during below-knee fracture surgery when a tourniquet (pressure cuff) is used. The goal is to see if this approach makes surgery more comfortable and safer.
AthensAges 18 years+ - NCT06669806Recruiting
TIPS Stent Graft for Cirrhosis Complications
This study tests a TIPS stent graft (a tiny mesh tube placed in the liver to relieve pressure) for people with cirrhosis and complications like bleeding or fluid buildup. It aims to see how well it works and if it's safe.
Changsha, HunanAges 18–75 - NCT07498244Recruiting
Collagen fingerprinting to understand lung blood pressure
This study uses a special imaging method to look at collagen (a building block of lung tissue) in people with COPD or pulmonary fibrosis. Researchers want to see if collagen patterns can help doctors better understand and treat high blood pressure in the lungs (pulmonary hypertension).
Graz, StyriaAges 18 years+ - NCT04388124RecruitingPhase 2
Test drug to block endothelin for hard-to-control blood pressure
This Phase 2 trial tests whether blocking endothelin (using bosentan and related treatments) can improve blood pressure in people with resistant hypertension—high blood pressure that stays high despite multiple medicines. It may help if your blood pressure is still above target even with the right combination of therapy.
RouenAges 18–80 - NCT07450222Enrolling by invitation
Improving high blood pressure care
This trial studies a new way to help people with high blood pressure get better control of their numbers. It uses a team approach to support you in managing your blood pressure and lowering your risk for heart problems.
Peoria, IllinoisAges 18 years+ - NCT07272798Recruiting
Heart confidence after pulmonary hypertension surgery
This study looks at how confident patients feel about managing their heart health after surgery for chronic thromboembolic pulmonary hypertension. It may help doctors understand how to better support recovery.
Damascus, Rif-dimashq GovernorateAges Any age - NCT06804161RecruitingPhase 3
Testing SGLT2 Inhibitors for Heart Health in Hypertension
This trial tests whether an SGLT2 inhibitor (a type of diabetes drug) can help prevent heart attacks, strokes, and other heart problems in people with high blood pressure. You may be eligible if you are 60 or older, have high blood pressure, and have had a heart or blood vessel event (like a heart attack or stroke) or have certain risk factors (like smoking, high cholesterol, or obesity).
Lübeck, Schleswig-HolsteinAges 60 years+ - NCT07005050Recruiting
Kidney nerve treatment for high blood pressure pilot study
This study tests a new treatment that uses a device to calm overactive nerves in the kidneys, which may help lower high blood pressure. It is for people who are already taking at least two blood pressure medications and still have high readings.
Birmingham, AlabamaAges 21–80 - NCT06515795Recruiting
Simple exercises to lower blood pressure in resistant hypertension
This study tests two simple, low-effort exercises (like squeezing a ball or holding a gentle pose) to see if they can help lower blood pressure for people whose high blood pressure doesn’t respond well to medication. The goal is to offer a safe, easy way to improve heart health.
AveiroAges 40–75 - NCT06205992Recruiting
Comparing 2D and 3D MRI scans for liver scarring and pressure
This study compares two types of MRI scans (2D and 3D) to see which is better at measuring liver scarring and high blood pressure in the liver's main vein. It is for people with cirrhosis who are already scheduled to have their liver vein pressure measured.
Shenyang, LiaoningAges 18–75 - NCT06823947RecruitingPhase 1
Study of KK3910 in healthy people and those with high blood pressure
This study tests a new medicine called KK3910, first in healthy volunteers to check safety, then in Japanese patients with essential hypertension (high blood pressure) to see if it helps lower blood pressure.
Hakata, FukuokaAges 18–80 - NCT07593027RecruitingPhase 1/Phase 2
Study of IMC-003 for pulmonary arterial hypertension
This trial tests a new drug called IMC-003 for people with pulmonary arterial hypertension (PAH). It aims to see if the drug can help improve symptoms and exercise ability when added to your current PAH medications.
Beijing, Beijing MunicipalityAges 18–75 - NCT07305922Recruiting
Treating delayed brain damage after a brain bleed
This study tests a treatment for people who have had a brain bleed (subarachnoid hemorrhage) and are at risk for delayed brain damage due to narrowed blood vessels. It looks at whether a special procedure to relax the vessels (spasmolysis) combined with raising blood pressure can prevent long-term harm.
StockholmAges 18 years+ - NCT07147075Enrolling by invitation
Improving blood pressure care through better doctor-patient talks
This study tests a training program for doctors to help them communicate better with patients who have high blood pressure. If you have high blood pressure and see a doctor at certain Duke Primary Care clinics, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06911632Recruiting
AI-assisted check for pulmonary hypertension in interstitial lung disease
This study uses an AI tool to help doctors decide if you should be tested for pulmonary hypertension (high blood pressure in the lungs), which can be a complication of interstitial lung disease. If the tool suggests you might have it, you may get an echocardiogram (an ultrasound of the heart) and a right heart catheterization (a test to measure pressure in the heart) to find out for sure.
Birmingham, AlabamaAges 18 years+ - NCT07213479Recruiting
Exercise and lifestyle changes for high blood pressure
This trial tests whether isometric exercises (like wall sits or planks) and lifestyle changes can help manage high blood pressure. It's designed for people already on blood pressure medication who want to try a gentle exercise program.
Newcastle upon TyneAges 18 years+ - NCT06481852RecruitingPhase 1
Gut bacteria transplant for pulmonary arterial hypertension
This trial tests whether a special combination of antibiotics, fecal transplant (gut bacteria from healthy donors), and a fiber supplement can help people with pulmonary arterial hypertension (PAH). It aims to see if improving gut health can improve PAH symptoms and overall well-being.
Minneapolis, MinnesotaAges 18–75 - NCT07243886Recruiting
Mobile app for high blood pressure or diabetes in pregnancy
This study tests whether a mobile app can help monitor your blood pressure or blood sugar during pregnancy if you have high blood pressure or diabetes. It aims to make it easier to manage your condition and stay connected with your healthcare team.
BiratnagarAges 18 years+ - NCT06770023RecruitingPhase 1
Bridge to lung transplant with ECMO for right heart failure
This study tests a special heart-lung support machine (ECMO) for people waiting for a lung transplant whose heart is failing due to high blood pressure in the lungs. The machine helps rest the heart and lungs until transplant surgery.
Jacksonville, FloridaAges 18–80
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Common questions
- Are there clinical trials for high blood pressure?
- Yes. Clin2 currently lists 984 recruiting high blood pressure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a high blood pressure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a high blood pressure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.