Clinical trials
Hypothyroidism clinical trials
Below are recruiting hypothyroidism clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07354048Recruiting
Thyroid health and its effect on liver function
This study looks at how thyroid problems (both overactive and underactive) may affect liver function tests. It aims to help researchers understand the link between thyroid and liver health.
SohagAges 20–60 - NCT07408765Recruiting
Physical activity and well-being in women with hypothyroidism
This study looks at how physical activity, social support, and fatigue affect psychological well-being in women with hypothyroidism. By joining, you may help researchers understand how lifestyle factors interact with your thyroid condition.
Oviedo, Principality of AsturiasAges 18 years+ - NCT07707830Recruiting
Thyroid and body health assessment for adults with low thyroid function
This study looks at how an underactive thyroid (hypothyroidism) affects internal organs, muscles, and bones. It uses ultrasound and physical measurements to understand these effects, which may help improve care.
AndijanAges 18–59 - NCT07781514Enrolling by invitation
Vitamin E as an add-on to levothyroxine for hypothyroidism
This trial tests whether adding vitamin E to your usual levothyroxine treatment helps improve thyroid function and reduce oxidative stress (a type of cell damage) in adults with hypothyroidism.
DhakaAges 18–75 - NCT05682482RecruitingPhase 3
Combination T4/T3 vs T4 alone for autoimmune hypothyroid fatigue
This trial compares adding T3 (plus T4) versus taking only T4 to see if it improves severe ongoing tiredness in people with autoimmune hypothyroidism. You would stay on your thyroid medicine plan during the study and be monitored with blood tests and health checks.
Almere StadAges 18 years+ - NCT07393165Recruiting
Thyroid hormone therapy for children with mild thyroid issues
This trial tests whether a thyroid hormone medication (levothyroxine) can improve heart function in children who have slightly high TSH levels but normal thyroid hormones. It may help children aged 4 to 15 with subclinical hypothyroidism.
Tanta, El-GharbiaAges 4–15 - NCT07380854Recruiting
Thyroid Hormone After Heart Bypass for Mild Underactive Thyroid
This study looks at whether giving thyroid hormone replacement to people with mild underactive thyroid (subclinical hypothyroidism) after heart bypass surgery improves their recovery. It is for adults who are scheduled for bypass surgery and have not recently used thyroid or anti-thyroid medications.
Seongnam-siAges 19–90 - NCT04831957Recruiting
Testing thyroid hormone changes after TAVI in older adults
This study looks at how thyroid problems may develop after a heart procedure called TAVI in people age 70 and older. It may help doctors spot thyroid side effects earlier so they can treat them sooner.
BrusselsAges 70 years+ - NCT05276856Recruiting
Study of recovery in secondary hypothyroidism with thyroid pills
This trial looks at how people with secondary hypothyroidism recover while taking T4 replacement therapy (thyroid hormone medicine). It may help doctors understand what recovery rates to expect and who might benefit from specific management.
HalifaxAges 18 years+ - NCT05316922RecruitingPhase 3
Lowering thyroid hormone during radiation to prevent low thyroid
This study tests whether using treatment to keep thyroid-stimulating signals low during radiation to the thyroid area can help prevent a treatment-related drop in thyroid function in children. It is aimed at kids with certain cancers whose radiation plan includes thyroid tissue.
MilanAges Any age - NCT06041204Recruiting
Thyroid hormone plus letrozole for PCOS and mild hypothyroidism
This trial tests whether adding a low-dose thyroid hormone (levothyroxine) to the standard fertility treatment letrozole improves pregnancy rates in women with both PCOS and mild hypothyroidism. It may help if you have trouble getting pregnant and have these two conditions.
CairoAges 20–40 - NCT06083636Recruiting
Better lab tests for people with hypothyroidism on levothyroxine
This study aims to improve lab tests for people with hypothyroidism who take levothyroxine. It compares their test results to healthy volunteers to see if doctors can make more accurate diagnoses.
Amsterdam, North HollandAges 18–100 - NCT06345339RecruitingPhase 2/Phase 3
Comparing Armour Thyroid to synthetic T4 for hypothyroidism
This study is testing whether Armour Thyroid (a natural pig-derived thyroid hormone) works as well as synthetic T4 (levothyroxine) for people with hypothyroidism. If you are already on a stable dose of levothyroxine, you may be able to switch to Armour Thyroid and see how it compares.
Birmingham, AlabamaAges 18–75 - NCT06724224Recruiting
Comparing thyroid hormone drugs for babies with low thyroid
This study compares two types of levothyroxine (a thyroid hormone medicine) to see which works better for newborns and children with congenital hypothyroidism (a condition where the thyroid gland doesn't work properly from birth). If your child was diagnosed early and lives in the Emilia-Romagna region of Italy, this trial may help find the best treatment.
Bologna, BolognaAges Up to 11 years - NCT06728735Recruiting
Genetic study for congenital hypothyroidism with normal thyroid location
This study uses advanced genetic testing to find the cause of permanent congenital hypothyroidism in children who have a thyroid gland in the normal position. It may help families understand why their child developed this condition.
Bologna, BolognaAges Up to 18 years - NCT06731764RecruitingPhase 2/Phase 3
New ways to treat hypothyroidism
This study tests a new approach for people with hypothyroidism who are already taking levothyroxine. You may be able to join if you are on a certain dose and do not have other health conditions that could affect the results.
Farmington, ConnecticutAges 18 years+ - NCT06757712Recruiting
Resistance training for quality of life in women with hypothyroidism
This trial tests if a special resistance-training schedule can improve quality of life in women with well-controlled hypothyroidism who are also overweight. You will follow a periodized (changing intensity) exercise plan and see how it affects your daily energy and well-being.
SuezAges 35–45 - NCT07257250Recruiting
Levothyroxine for IVF in women with mild thyroid issues
This study tests whether taking levothyroxine (a thyroid hormone medication) before IVF or ICSI with frozen embryo transfer improves pregnancy rates in women with subclinical hypothyroidism (a mild thyroid condition). It aims to see if this treatment helps women like you have a better chance of getting pregnant.
Ho Chi Minh City, Ho Chi MinhAges 18–45 - NCT07280104Recruiting
Infants with congenital hypothyroidism and development
This study looks at how babies with primary congenital hypothyroidism (low thyroid hormone from birth) grow and develop after being treated. It helps doctors understand if treatment helps them reach normal milestones.
NiğdeAges 6 months–1.5 years - NCT07421869Recruiting
Recovery from immune therapy-related hypothyroidism
This trial looks at whether patients can recover from low thyroid function caused by immune checkpoint inhibitor drugs. If you've finished immune therapy and are on thyroid medication, you may be able to stop or reduce it.
Seongnam-siAges 19 years+ - NCT07603817Recruiting
Thyroid Disease and Fatty Liver Disease Study
This study looks at the connection between thyroid problems (especially when the thyroid doesn't make enough hormone) and a common liver condition where fat builds up in the liver. Researchers want to understand how these two conditions relate to each other in people without diabetes.
Sohag, Sohag GovernorateAges 18 years+ - NCT06864039Enrolling by invitation
Quality of life in treated congenital hypothyroidism
This study looks at the long-term quality of life for people who were diagnosed with congenital hypothyroidism at birth and started treatment within the first month of life. It aims to understand how early treatment affects their health and well-being as they grow up.
NaplesAges 16–21 - NCT06660888Enrolling by invitation
Study of fatigue, depression, and anxiety in people with low thyroid
This study looks at how common fatigue, depression, and anxiety are in people with hypothyroidism (underactive thyroid). It aims to understand if these symptoms are linked to thyroid hormone levels.
Asyut, AssuitAges 18–60 - NCT07747103RecruitingPhase 3
Porcine thyroid extract for hypothyroidism
This trial tests a new porcine (pig) thyroid hormone replacement tablet for people with primary hypothyroidism (underactive thyroid). It aims to see if this treatment is safe and effective compared to current levothyroxine therapy.
Modesto, CaliforniaAges 18–75
Hear when a new Hypothyroidism trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Hypothyroidism trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for hypothyroidism?
- Yes. Clin2 currently lists 39 recruiting hypothyroidism studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a hypothyroidism trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a hypothyroidism trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.