Clinical trials
Immune System clinical trials
Below are recruiting immune system clinical trials, each written for real people, not researchers. We’re tracking 126 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05655273Enrolling by invitationPhase 4
Switch tacrolimus timing after liver transplant to Envarsus
This trial looks at whether changing your maintenance anti-rejection medicine from Prograf (usually twice daily) to Envarsus (once daily) can help keep your liver and kidney function stable. It targets people who may be having kidney side effects, symptoms from tacrolimus, or trouble taking a twice-daily medicine.
Toronto, OntarioAges 18–99 - NCT05134779Recruiting
Study aims to tailor cancer treatment to your biology
This study looks at how genes, the cancer environment, and your immune system interact to develop treatments that work better for people with breast cancer. It may help researchers learn why some treatments work for certain people and not others.
New York, New YorkAges 18–90 - NCT05334888Recruiting
Study how sex and gut bacteria relate to heart risk
This study follows people over time to understand how sex-related factors and gut bacteria may affect heart and blood-vessel risk. It may help researchers identify who could benefit from earlier prevention, based on personal risk patterns.
BerlinAges 18–50 - NCT04663204RecruitingPhase 2
Sparsentan study for IgA kidney disease in adults
This Phase 2 trial studies whether sparsentan is safe and can slow down kidney damage in adults with IgA nephropathy (IgAN). Participants may receive sparsentan to improve kidney-related measures such as protein in the urine.
Cambridge, EnglandAges 18 years+ - NCT04323566Enrolling by invitationPhase 2
Rituximab for OCD or psychosis linked to immune inflammation
This trial tests rituximab (an immune system medicine) to see if it can reduce OCD symptoms and/or psychosis when there are signs the immune system may be involved. You may be considered if other standard psychiatric treatments have not helped enough and your illness seems relatively recent with possible inflammation clues.
UppsalaAges 18–55 - NCT04242095Recruiting
Immunotherapy side effects research study
This study collects blood, stool, and tissue samples from people who have had side effects from immunotherapy (a type of cancer treatment that helps your immune system fight cancer). It aims to learn more about these side effects, so doctors can better manage them in the future.
Anchorage, AlaskaAges Any age - NCT04174066Recruiting
Study on kidney damage in children and adults with MGLS or FSGS
This trial collects medical data and blood/urine samples from patients with minimal change disease or focal segmental glomerulosclerosis (FSGS) to better understand how the immune system damages kidney cells.
NiceAges 1 year+ - NCT03908736RecruitingPhase 2
Zinc supplements study for adults on the Navajo Nation
This study tests how daily zinc supplements affect participants in specific Navajo Nation communities by checking changes in blood and urine. It’s mainly meant for adults who are willing to take zinc and come to scheduled study visits.
Albuquerque, New MexicoAges 21–64 - NCT03207854Recruiting
Donate blood and immune samples for cancer, blood, or healthy volunteers study
This study collects blood and immune-related samples from people with cancer, certain immune-related blood conditions, or healthy volunteers. It helps researchers understand immune changes and may support future diagnosis or treatments.
Los Angeles, CaliforniaAges 19 years+ - NCT01503190Recruiting
Study of how breast cancer affects the immune system
This study looks at how the immune system changes in people with breast cancer, using patient tissue samples. It may help researchers understand immune responses in young women and guide future cancer treatments.
Aurora, ColoradoAges 18 years+ - NCT02257892Recruiting
Study of rare immune system genetic disorders
This study looks for genetic causes of immune problems, such as unusually frequent infections, abnormal allergies, or autoimmune or inflammation conditions. It may help by improving how doctors understand these disorders and by matching families with possible genetic diagnoses.
Bethesda, MarylandAges 3–99 - NCT02579967RecruitingPhase 2
Stem cell transplant for primary immune system disorders
This study tests whether an allogeneic stem cell (bone marrow) transplant can correct an inherited immune problem in people with severe primary immunodeficiencies. It may help reduce life-threatening infections and improve quality of life, depending on your overall health and donor match.
Bethesda, MarylandAges 4–75 - NCT01351545Recruiting
Cryopreserved cord blood access program for transplant patients
This trial studies an organized way to obtain and distribute unlicensed (not FDA-approved for general use) stored cord blood units that have been frozen and kept. It may help people who need a cord blood transplant but don’t fit the “licensed cord blood only” options.
Birmingham, AlabamaAges Any age - NCT01568697Recruiting
Studying gum disease in people with immune and genetic differences
This study looks at how mouth bacteria and the immune system may work together to cause gum disease (periodontitis), especially in people with certain genetic immune problems. It may help researchers understand what drives severe gum disease and how to better monitor or treat it in the future.
Bethesda, MarylandAges 7–100 - NCT01386437Recruiting
Study immune problems and fungal infections
This study looks at how immune system problems relate to fungal infections, using medical records and lab tests on blood and tissue. It may help researchers understand the cause of these infections—especially for people with inherited immune conditions—and improve future care.
Bethesda, MarylandAges 1 day–99 years - NCT00001406Recruiting
Understanding eosinophil behavior in rare blood and tissue conditions
This research study examines how eosinophils (a type of white blood cell) behave and function when they become abnormally high in the blood or tissues. Researchers want to understand these conditions better to potentially improve treatment options.
Bethesda, MarylandAges 1–100 - NCT00006150Recruiting
Understanding Hyper-IgE Syndrome: Natural History and Genetics
This study follows people with or suspected Hyper-IgE syndrome (a rare immune disorder causing repeated infections and skin problems) to understand how the condition develops, how best to manage it, and which genes are involved. Researchers also welcome healthy relatives of patients to help identify genetic patterns.
Bethesda, MarylandAges 1 month–120 years - NCT00001979Recruiting
Understanding Immune System Kidney Disease
This research study looks at kidney diseases caused by the immune system—conditions where your body's defense system mistakenly attacks the kidneys. Researchers will study your medical history, blood, and urine to better understand these diseases and potentially improve treatment.
Bethesda, MarylandAges 10–99 - NCT07512518Recruiting
Study of Long-Term Viral Brain Infections
This study follows patients with chronic viral infections affecting the brain and spinal cord. Researchers will collect spinal fluid samples and track your health over one year to better understand these infections and improve care.
Beijing, Beijing MunicipalityAges 14 years+ - NCT07348055RecruitingPhase 1/Phase 2
A study of GR1803 for lupus
This trial tests a new drug called GR1803 for people with systemic lupus erythematosus (SLE), an autoimmune disease that causes inflammation. It may help reduce disease activity when standard treatments haven't worked well enough.
Wuhan, HubeiAges 18–60 - NCT06829238RecruitingPhase 4
Metformin to boost immune function in people with a history of drug use
This study tests whether metformin, a common diabetes drug, can help restore immune system balance in people who have used injection drugs in the past. It includes both people living with HIV and those who are HIV-negative.
Birmingham, AlabamaAges 18–64 - NCT06685887RecruitingPhase 2
Chemo, Immunotherapy, and Heated Belly Chemo for Stomach Cancer Spread
This trial tests combining standard chemotherapy and immunotherapy (tirelizumab) with heated chemotherapy given directly into the belly. It aims to treat stomach cancer that has spread to the abdominal lining, and may help shrink or control the cancer.
Wuhan, HubeiAges 18–75 - NCT03953768Recruiting
Testing a new vagus nerve stimulator for gut and immune health
This study looks at what happens to your immune system and stomach/gut function after getting a vagus nerve stimulator (VNS) for the first time for epilepsy. It may help doctors understand whether the device benefits more than seizures.
Louisville, KentuckyAges birth–60 years - NCT07174843RecruitingEarly Phase 1
CAR-T cell therapy for autoimmune diseases
This study tests a new type of cell therapy called CAR-T cells that target three proteins (CD19, CD22, BCMA) to treat people with autoimmune diseases that have not responded to standard treatments. The goal is to see if it can reset the immune system and reduce disease activity.
Shanghai, Shanghai MunicipalityAges 18–70
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Common questions
- Are there clinical trials for immune system?
- Yes. Clin2 currently lists 126 recruiting immune system studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a immune system trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a immune system trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.