Clinical trials
Knee Arthritis Osteoarthritis clinical trials
Below are recruiting knee arthritis osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 211 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07396233Recruiting
Knee Osteoarthritis Therapy: Diagonal Movement Patterns
This trial tests a type of physical therapy called proprioceptive neuromuscular facilitation for people with knee osteoarthritis. It may help reduce pain and improve how well your knee works.
Karachi, SindhAges 40–60 - NCT07383740Recruiting
Reliability of a gentle bike test for hip or knee osteoarthritis
This study checks whether a simple, low-effort bike test gives consistent results for people with hip or knee osteoarthritis. It helps doctors understand how well this test can measure your fitness without pushing you too hard.
GothenburgAges 30 years+ - NCT06129214Recruiting
Partial tendon cleaning to reduce knee clicking after replacement
This trial studies a partial cleaning procedure on the quadriceps tendon during knee replacement to reduce clicking or rubbing sensation (crepitus). It is only for people getting a specific type of knee implant (posterior-stabilized) and whose kneecap is not replaced.
Seoul, GangnamGuAges 19 years+ - NCT07323342Recruiting
Hyaluronic acid plus fibrinogen for knee arthritis
This study tests whether a combination of two natural substances—hyaluronic acid (a joint lubricant) and fibrinogen (a blood protein that helps healing)—given as an injection into the knee, can safely reduce pain and improve function in people with knee osteoarthritis. It is for Vietnamese patients who have not recently used certain painkillers or had other knee treatments.
Ho Chi Minh CityAges 45–75 - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80 - NCT07313020Enrolling by invitationEarly Phase 1
Handheld imaging to track stem cells in knee osteoarthritis
This trial tests a new handheld imaging device (MPI) to track stem cells injected into the knee. It aims to see if the device can safely monitor how the stem cells move and work in people with knee osteoarthritis.
Haikou, HainanAges 18–75 - NCT06357741Recruiting
Desuzumab for knee osteoarthritis
This study tests a new medicine called Desuzumab for knee osteoarthritis. It looks at whether the medicine can help reduce pain and improve joint function.
Wuhan, HubeiAges 45–75 - NCT07198555RecruitingPhase 1
Study of BBM-A101 for knee osteoarthritis
This trial tests a new medicine called BBM-A101 for people with moderate knee osteoarthritis. It aims to see if it is safe and helps reduce pain and improve function.
Shenzhen, GuangdongAges 40–75 - NCT07198750Recruiting
Pulsed magnetic field therapy for knee osteoarthritis in older adults
This trial tests two types of high-intensity pulsed electromagnetic field therapy (one using two modes, another using one mode) to see if they can reduce pain and improve function in older adults with knee osteoarthritis. You would attend 9 treatment sessions and do exercises at home.
Guadalajara, JaliscoAges 60 years+ - NCT07178951Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial tests a non-surgical treatment that uses ultrasound to target nerves causing pain on the inner side of your knee due to osteoarthritis. It may help reduce pain and improve function for people with moderate to severe knee pain.
North York, OntarioAges 18 years+ - NCT06956222Recruiting
Home vs in-person rehab for knee osteoarthritis
This study compares doing physical therapy exercises at home through a video call (tele-rehab) versus doing them in person at a clinic. It is for people with mild to moderate knee osteoarthritis to see if home rehab works just as well.
JeddahAges 40–80 - NCT07130630Recruiting
Pain and activity confidence in Vietnamese knee osteoarthritis
This study tests a questionnaire that measures how confident people with knee osteoarthritis feel about doing daily activities despite pain. Your answers will help doctors better understand and support Vietnamese-speaking patients.
Ho Chi Minh City, Ho Chi MinhAges 50 years+ - NCT06859164RecruitingPhase 2
Knee artery treatment for chronic osteoarthritis pain
This trial tests a procedure called genicular artery embolization to reduce pain in people with knee osteoarthritis that hasn't improved with other treatments. The goal is to see if blocking certain blood vessels can relieve pain and help you avoid or delay knee replacement surgery.
Chicago, IllinoisAges 40–80 - NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06946329Enrolling by invitation
Water exercise for knee pain in obese men
This study tests whether a supervised water exercise program (called WATERinMOTION) can reduce knee pain and improve movement in obese men with knee osteoarthritis. It may help if you are looking for a gentle, joint-friendly way to manage your knee pain.
Zahedan, Sistan and BaluchestanAges 45–65 - NCT06911359RecruitingPhase 2
Anti-inflammatory vs. Prolotherapy for Knee Osteoarthritis
This study tests whether anti-inflammatory medications or dextrose prolotherapy (sugar water injections) can reduce knee pain and improve function in people with knee osteoarthritis. If you are a military healthcare beneficiary with moderate to severe knee pain, you may be able to join.
Travis AFB, CaliforniaAges 45–75 - NCT06893250Enrolling by invitationPhase 2/Phase 3
Orthobiologic treatment for knee osteoarthritis
This study tests a treatment made from your own body's healing components to reduce knee pain. It may help people with mild to moderate knee osteoarthritis who haven't had knee surgery or strong pain relievers lately.
Tromsø, TromsøAges 40–70 - NCT06845553RecruitingPhase 2
Vutiglabridin for knee osteoarthritis: a phase 2 study
This trial tests an experimental pill called Vutiglabridin for people with knee osteoarthritis. It aims to see if the drug is safe and effective at reducing knee pain and improving function.
Seongnam-si, Gyeonggi-doAges 40–75 - NCT06570291RecruitingPhase 3
Stem cell injection for knee osteoarthritis
This trial tests a new treatment using donor stem cells injected into the knee for people with moderate knee osteoarthritis. It aims to see if these cells can reduce pain and improve function.
Shanghai, ChinaAges 40–75 - NCT06809998RecruitingPhase 1/Phase 2
Steroid injection in non-surgical knee before knee replacement
This study tests whether a single steroid injection in the healthy knee (the one not being replaced) can reduce pain and improve recovery after total knee replacement. It may help people who have arthritis in both knees but are only having one replaced now.
Toronto, OntarioAges 18 years+ - NCT06782529RecruitingPhase 4
Knee injection study for patients with obesity and arthritis
This study tests if steroid injections for knee arthritis work in people with obesity. It may help you manage pain and avoid surgery.
Jacksonville, FloridaAges 55–85 - NCT06779071Enrolling by invitationPhase 3
NPNP-001 injection for knee osteoarthritis pain
This study tests a new medicine called NPNP-001 for people with knee osteoarthritis who have not gotten enough relief from other treatments. The medicine is given as an injection into the knee to see if it can reduce pain and improve function.
SeoulAges 40 years+ - NCT06781463Recruiting
Knee arthritis treatment registry
This study tracks patients with knee arthritis who undergo a procedure called genicular artery embolization (GAE), a minimally invasive option for those not ready for or not eligible for knee replacement. The goal is to see how well GAE works for pain relief.
Chicago, IllinoisAges 18 years+
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Common questions
- Are there clinical trials for knee arthritis osteoarthritis?
- Yes. Clin2 currently lists 211 recruiting knee arthritis osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee arthritis osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee arthritis osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.