Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06389435Recruiting
Robotic vs. conventional knee replacement study
This trial compares robotic-assisted knee replacement surgery to the standard, conventional method. It aims to see if the robotic technique leads to better outcomes for patients getting a total knee replacement.
StockholmAges 18 years+ - NCT06090097Recruiting
Game therapy for knee osteoarthritis
This trial tests a game-based therapy that uses biofeedback to help strengthen your knee. It may help you move better and feel less pain.
Chapel Hill, North CarolinaAges 30–75 - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+ - NCT07105657Recruiting
Rehabilitation after hip or knee replacement
This trial tests if three weeks of intensive rehabilitation helps people who still have physical problems after a total hip or knee replacement. It aims to improve your recovery and function.
BrædstrupAges 18 years+ - NCT07134244Recruiting
Predicting cartilage damage and pain after knee injury or early arthritis
This study uses computer models and MRI scans to predict how knee cartilage and pain may change over time in people with early osteoarthritis or a recent ACL tear. It aims to find better ways to manage these conditions and prevent long-term damage.
Aalborg, North DenmarkAges 18–70 - NCT06451783Enrolling by invitationEarly Phase 1
Herbal Medicine and Joint Manipulation for Knee Osteoarthritis
This trial tests a combination of a Chinese herbal formula (Shengyu Decoction) and a hands-on joint manipulation technique (Lijin Manipulation) to improve knee movement and reduce pain in people with knee osteoarthritis. It uses special 3D walking analysis to see how well the treatment works.
ShanghaiAges 45–85 - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT06462625Recruiting
Knee realignment surgery for arthritis with bowed legs
This study tests how well a realignment surgery (osteotomy) works for people with mild knee arthritis and a bent knee that's at least 3 degrees off center. The surgery may also fix other knee problems like a torn meniscus or ligament at the same time.
BolognaAges 18–70 - NCT06603103Recruiting
Comparing two knee implants in total knee replacement
This study compares two types of knee implants (SpheriKA and Origin) used in total knee replacement surgery with a specific alignment technique. The goal is to see which one may lead to better outcomes for patients needing a first knee replacement.
MérignacAges 18 years+ - NCT07423858Recruiting
E-coach for hip and knee arthritis advice
This study tests a digital coach that gives you personalized advice to manage your hip or knee arthritis. It aims to help you get the right guidance at the right time.
UtrechtAges 45 years+ - NCT07361198Recruiting
Knee artery embolization for arthritis pain
This trial tests a minimally invasive procedure to block small blood vessels in the knee, which may reduce pain from osteoarthritis. It's for people with ongoing knee pain even after standard treatments like medication or physical therapy.
Ústí nad LabemAges 40–80 - NCT07496203Recruiting
BETY program after knee injections for osteoarthritis
This trial tests if a special exercise and education program called BETY helps people with knee osteoarthritis feel better after getting a knee injection. You may qualify if you had a knee injection in the last month and have moderate knee arthritis.
Ankara, SamanpazarıAges 18 years+ - NCT06911437Enrolling by invitation
Knee pain relief with Chinese formula and massage
This study tests if combining a Chinese herbal formula called Xiaoyu Zhitong with a gentle drainage massage can reduce knee pain and swelling. It may help people whose knee symptoms are worse in cold, damp weather.
BeijingAges 25–70 - NCT05302934Recruiting
Testing a knee-surgery app and sensor after knee replacement
This trial checks whether a data platform that uses a wearable sensor and a phone app works well for people getting a total knee replacement. It may help make follow-up care more organized and easier by capturing recovery information.
Konstanz, Baden-WurttembergAges 18 years+ - NCT07695168Recruiting
Digital course and rehab for knee osteoarthritis
This study tests whether a digital program with special sensors and a digital twin can help reduce knee pain and improve mobility in older adults with knee osteoarthritis. It also includes healthy adults for comparison.
TaipeiAges 20–80 - NCT06701474Recruiting
Knee replacement recovery: comparing body composition groups
This study looks at how well people recover after total knee replacement, comparing those with different body composition levels. The goal is to see if a measure called 'phase angle' affects recovery of strength and function.
Yongin-si, Gyeonggi-doAges 55 years+ - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06976138Recruiting
Using Light or ions to Improve Sleep and Pain After Knee Surgery
This study tests whether a special bright light or negative ion therapy can help older adults sleep better and have less pain after knee replacement surgery. It's for people with knee arthritis who already have trouble sleeping and are scheduled for one knee replacement.
Baltimore, MarylandAges 60 years+ - NCT07763158Recruiting
Treatment for severe knee pain using artery embolization
This study tests a procedure that blocks tiny arteries in the knee to reduce pain from severe arthritis. It is for people who cannot have knee replacement surgery because of other health issues.
Jeddah, Mecca RegionAges 18 years+ - NCT05806021RecruitingPhase 4
Tested different cortisone doses for knee osteoarthritis pain
This trial compares different doses of injected cortisone (triamcinolone) directly into the knee to see which dose helps knee osteoarthritis pain most. You may be enrolled in a group receiving a 5 mg, 10 mg, or 40 mg dose if you meet the study’s knee and health requirements.
Montreal, QuebecAges 50 years+ - NCT07746284Enrolling by invitation
Understanding knee osteoarthritis through computer modeling
This study looks at how knee osteoarthritis pain works and aims to build a computer model to better understand it. By joining, you may help doctors improve future treatments for chronic knee pain.
Herndon, VirginiaAges 18–99 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT04427709RecruitingPhase 2
Testing a brain-activity measure using oxytocin and eye movements
This study tests whether a particular brain-activity signal—seen in small rhythmic eye movements—can be measured reliably. It also looks at how oxytocin (a hormone used in medical settings) affects that signal.
Winston-Salem, North CarolinaAges 18–75
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.