Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 411 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07746284Enrolling by invitation
Understanding knee osteoarthritis through computer modeling
This study looks at how knee osteoarthritis pain works and aims to build a computer model to better understand it. By joining, you may help doctors improve future treatments for chronic knee pain.
Herndon, VirginiaAges 18–99 - NCT06407427Recruiting
Mobile app for recovery after hip, knee, or spine surgery
This study tests whether a mobile app can help with physical therapy after common bone or joint surgeries. You may qualify if you recently had a hip fracture, hip or knee replacement, or spine surgery without paralysis. The app guides your exercises at home.
New Haven, ConnecticutAges 18 years+ - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT04427709RecruitingPhase 2
Testing a brain-activity measure using oxytocin and eye movements
This study tests whether a particular brain-activity signal—seen in small rhythmic eye movements—can be measured reliably. It also looks at how oxytocin (a hormone used in medical settings) affects that signal.
Winston-Salem, North CarolinaAges 18–75 - NCT05211986RecruitingPhase 1/Phase 2
Test injection safety for knee osteoarthritis muscle weakness
This Phase 1/2 trial studies whether an injection called IMM01-STEM is safe and well-tolerated for people with knee osteoarthritis who also have muscle weakness. It also looks at whether the treatment could help in this group, while carefully monitoring side effects.
Irvine, CaliforniaAges 50–75 - NCT05514405Recruiting
Testing two anesthesia medicines to prevent confusion after surgery
This trial tests whether using remimazolam or propofol during hip or knee replacement surgery can lower the risk of postoperative delirium, a sudden, short-term confusion that can happen after anesthesia. It may help people who are at higher risk of postoperative confusion by finding the safer anesthesia approach.
SeoulAges 65–100 - NCT05785884Recruiting
Diet program to help knee osteoarthritis pain
This trial studies whether different diet approaches can reduce knee pain in people with knee osteoarthritis who have certain eating patterns. It may help by changing diet-related factors that can affect inflammation and pain.
Birmingham, AlabamaAges 40–75 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Birmingham, AlabamaAges 18 years+ - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06267482RecruitingPhase 4
Using a robot for knee replacement surgery
This trial tests if a robot-assisted device (ROSA) helps with challenging knee replacements. It compares it to the standard surgery for people with mild knee bowing who need a first-time knee replacement.
London, OntarioAges 21–80 - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT06532851Recruiting
Exercise therapy for knee cartilage health
This study tests whether specific exercises can improve your knee cartilage health and daily function. It is for people with a meniscus tear who are at risk for knee arthritis but don't have arthritis yet.
Ar RamthaAges 35–55 - NCT06553313Recruiting
Knee pain study for adults over 50
This study looks at proteins in the blood to understand knee health. It is for adults over 50 who do not have knee pain.
TaichungAges 50 years+ - NCT06608992RecruitingPhase 4
Studying a powder to reduce bleeding in knee replacement
This trial tests a powder called SURGICEL® that may help control bleeding during knee replacement surgery. People with severe knee arthritis who are having their first knee replacement may be able to join.
Beijing, Beijing MunicipalityAges Any age - NCT07006883Recruiting
Yoga program for knee osteoarthritis
This trial tests whether a yoga program can improve daily function in people with knee osteoarthritis. It may help reduce pain and stiffness while improving mobility.
São PauloAges 40–80 - NCT07016672Recruiting
PRP vs. hyaluronic acid for advanced knee arthritis
This study compares two treatments—platelet-rich plasma (PRP) and hyaluronic acid (a lubricating injection)—for people with severe knee arthritis seen on MRI. The goal is to see which better reduces pain.
Toulon, VarAges 18 years+ - NCT07215572Recruiting
Group physical therapy for veterans with knee osteoarthritis
This trial studies whether a group physical therapy program can help veterans with knee osteoarthritis. It aims to see if this approach is practical and effective for improving knee pain and function.
Durham, North CarolinaAges Any age - NCT07301242Recruiting
Study of ciprofol in older adults having limb surgery
This trial studies how the drug ciprofol works in older adults undergoing elective orthopedic limb surgery. The goal is to understand how the body processes the drug and how it affects patients, which may help improve its use for anesthesia in the elderly.
ShanghaiAges 65 years+ - NCT07304323Recruiting
Predicting recovery after hip or knee replacement in 2018
This trial is for people who had hip or knee replacement surgery in 2018 at a specific hospital in Milan and then went to its rehabilitation unit. Researchers will use your medical records to build and test a tool that predicts recovery after joint replacement.
MilanAges 18 years+ - NCT07316933Recruiting
Exercise with light blood flow restriction before knee replacement
This trial tests if a specific type of exercise, done with a cuff that lightly restricts blood flow to your leg, can help you get stronger and recover better while you wait for knee replacement surgery. The blood flow restriction is carefully controlled and adjusted during exercise, which may make the workout more effective.
Valencia, ValenciaAges 50–85 - NCT07339137Recruiting
PRP injections for chronic knee osteoarthritis
This trial tests if platelet-rich plasma (PRP) injections into and around the knee joint can reduce pain and improve function for people with moderate knee osteoarthritis who haven't gotten relief from other treatments.
Ankara, ÇankayaAges 40–65 - NCT07347028Recruiting
Trigger point injections for knee osteoarthritis pain
This trial tests whether injecting medication into muscle knots (trigger points) can reduce knee pain in people with knee osteoarthritis. It may be an option if other treatments haven't helped enough.
Beijing, Beijing MunicipalityAges 45 years+ - NCT07386600Recruiting
Comparing two drugs for knee replacement pain relief
This trial tests two different drugs (dexamethasone and dexmedetomidine) added to a standard nerve block for knee replacement. It aims to see which one provides better pain control after surgery.
PoznanAges 65–100 - NCT02993029Recruiting
Fluoride scan–guided treatment for painful knee arthritis
This trial studies a targeted treatment using a fluoride-related injection to help reduce pain from knee osteoarthritis. To join, you need a painful osteoarthritis knee and a specific bone-scan finding (SUV above 10) on an imaging test.
Shanghai, Shanghai MunicipalityAges 40 years+
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 411 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.