Clinical trials
Knee Osteoarthritis clinical trials
Below are recruiting knee osteoarthritis clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT06917404RecruitingPhase 3
Knee osteoarthritis pain study: comparing a new injection to placebo
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Peoria, ArizonaAges 18 years+ - NCT06986694Recruiting
Voodoo flossing for knee arthritis pain and mobility
This study tests if a special flossing technique (tight elastic bands wrapped around the knee) can improve pain, stiffness, and walking in people with knee osteoarthritis. It is designed for patients who have had knee pain for at least 3 months and have trouble walking or balancing.
Lahore, Punjab ProvinceAges 45–65 - NCT07178951Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial tests a non-surgical treatment that uses ultrasound to target nerves causing pain on the inner side of your knee due to osteoarthritis. It may help reduce pain and improve function for people with moderate to severe knee pain.
North York, OntarioAges 18 years+ - NCT07219771RecruitingPhase 3
Testing MOTYS injection for knee osteoarthritis pain
This trial tests an injection called PTP-001 (MOTYS) for people with mild to moderate knee osteoarthritis. It aims to see if the injection can reduce knee pain and improve function.
Birmingham, AlabamaAges 40–80 - NCT02915120Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial studies whether a targeted, ultrasound-guided “pulsed” radiofrequency treatment can reduce long-lasting knee pain from osteoarthritis. It may help if your knee pain is not improving with common medicines and injections.
Palma, Balear IslandsAges 40 years+ - NCT07439575Recruiting
Wound closure methods in hip and knee replacement
This study compares different ways of closing the wound after hip or knee replacement surgery. It looks at which methods heal best with fewer problems.
Istanbul, IstanbulAges 30 years+ - NCT07580716RecruitingPhase 2
Knee Injection Treatment for Moderate Osteoarthritis
This study tests a new cell-based injection (Allocetra) directly into the knee joint for people with moderate osteoarthritis who haven't benefited from other treatments. The goal is to reduce pain and improve knee function.
Longwood, FloridaAges 64 years+ - NCT06887829Recruiting
Radiation Therapy for Knee Osteoarthritis
This study tests a low-dose radiation treatment for knee osteoarthritis pain. If you have moderate arthritis pain and are a Mayo Clinic patient in Rochester, you may be able to join.
Rochester, MinnesotaAges 50–100 - NCT07308834RecruitingPhase 1/Phase 2
Injection for knee osteoarthritis pain
This study tests an injection called CX-011 for people with knee osteoarthritis who still have moderate to severe pain despite trying other treatments. The goal is to see if the injection can reduce pain and improve knee function.
Los Angeles, CaliforniaAges 40–75 - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT05100966Recruiting
Exercise program for people waiting for hip or knee replacement
This trial tests a “getting fit” program to help people who are somewhat frail before hip or knee replacement surgery. It aims to improve fitness while you wait for surgery, which may help you feel stronger for recovery.
Calgary, AlbertaAges 60 years+ - NCT05543941Recruiting
Test advanced irrigation during knee, hip, or shoulder replacement
This trial studies a cleaning solution used during surgery to lower the risk of complications and improve outcomes after joint replacement. It may be an option if you’re having a planned knee, hip, or humerus (shoulder) replacement and meet the specific health and allergy requirements.
Vancouver, British ColumbiaAges 18 years+ - NCT06249958Recruiting
Personalized rehabilitation after hip or knee replacement
This study looks at how personalized rehabilitation after hip or knee replacement surgery can improve your quality of life. It is for people who had their surgery at IRCCS Galeazzi Orthopedic Institute in 2019.
Milan, ItaliaAges 18 years+ - NCT06497140RecruitingPhase 3
Genicular artery embolization for painful knee osteoarthritis
This trial tests a new procedure called genicular artery embolization to treat knee pain from osteoarthritis. If you have moderate to severe knee pain and are not a candidate for knee replacement or other surgery, this treatment may help reduce pain and improve function.
ParisAges 40–90 - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07302204Recruiting
Exercise for knee osteoarthritis pain relief
This study compares two types of exercise — aerobic (like walking or cycling) versus specific therapeutic exercises — to see which one better helps people with knee osteoarthritis who do not get pain relief from exercise. It aims to find an exercise plan that reduces knee pain and improves movement.
São PauloAges 40–75 - NCT07329023Recruiting
Acupressure for Knee Arthritis in Older Chinese Adults
This trial tests whether learning self-administered acupressure (a type of massage using fingertips) can help older Chinese adults with knee arthritis manage their pain and stiffness without medication. If you join, you will receive training in a community setting and use a smartphone app to track your progress.
KowloonAges 60 years+ - NCT07489521RecruitingPhase 4
Arthrosamid vs. steroid for knee arthritis pain
This trial compares a new injection called Arthrosamid with a standard steroid injection to see which works better for knee arthritis pain over time. It may help you if you have knee arthritis and have not had recent injections or knee surgery.
Dublin, DublinAges 18–100 - NCT07575425Recruiting
Balance Platform Exercises for Knee Osteoarthritis
This study tests whether special balance exercises on a moving platform can improve steadiness and walking in people with moderate knee osteoarthritis. The goal is to see if this type of training helps reduce pain and improve mobility.
AnkaraAges 45–65 - NCT07580222Recruiting
Using Mobile Technology to Track Knee Arthritis Health
This study uses smartphone or tablet technology to measure how your knee osteoarthritis (wear-and-tear arthritis) changes over time. You'll be helping researchers understand how well a previous arthritis treatment works by tracking your knee health at home.
Palo Alto, CaliforniaAges 30 years+ - NCT06074900Recruiting
Waiting for hip or knee replacement study
This study follows people waiting for hip or knee replacement surgery due to osteoarthritis. It helps researchers understand how to better support patients during the wait.
London, OntarioAges 18 years+ - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT06891807Recruiting
Robotic vs augmented reality knee replacement
This study compares two advanced technologies for total knee replacement: a robot that uses a CT scan for guidance versus an augmented reality system that uses no scan. The goal is to see which approach leads to better outcomes for patients with osteoarthritis.
Sint-Martens-Latem, Oost-VlaanderenAges 18–85
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Common questions
- Are there clinical trials for knee osteoarthritis?
- Yes. Clin2 currently lists 408 recruiting knee osteoarthritis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee osteoarthritis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee osteoarthritis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.