Clinical trials
Knee Pain clinical trials
Below are recruiting knee pain clinical trials, each written for real people, not researchers. We’re tracking 180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07511842Recruiting
Keeping Your Knee Still After Surgery to Reduce Pain
This study tests whether keeping your knee immobilized (held still) for 72 hours after knee replacement surgery helps reduce pain. Researchers will compare this approach to standard care to see if it makes recovery easier.
Sherbrooke, QuebecAges 18 years+ - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT07248072Recruiting
Nerve blocks for better recovery after knee replacement
This trial tests two types of nerve blocks—iPACK and BiFeS—to see if they help people feel better and recover faster after total knee replacement surgery. It compares adding these blocks to the usual spinal anesthesia.
ErzurumAges 18–75 - NCT06514716Recruiting
Steroid shot vs. standard procedure for knee arthritis
This study tests whether a corticosteroid shot (a strong anti-inflammatory medicine) into the knee joint works better than the standard GAE procedure for people with knee osteoarthritis. It aims to see which approach provides better pain relief and function.
ZagazigAges 18–80 - NCT07712419Recruiting
Predicting response to knee nerve block with ultrasound
This study is testing if a type of ultrasound can help predict how well a nerve block injection will work for people with severe knee osteoarthritis. It may help doctors choose the best treatment for your pain.
IstanbulAges 45 years+ - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT07496203Recruiting
BETY program after knee injections for osteoarthritis
This trial tests if a special exercise and education program called BETY helps people with knee osteoarthritis feel better after getting a knee injection. You may qualify if you had a knee injection in the last month and have moderate knee arthritis.
Ankara, SamanpazarıAges 18 years+ - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT06336447Recruiting
Virtual reality and nerve block for chronic knee pain
This study tests whether using virtual reality (VR) before a standard heat-based nerve block (radiofrequency ablation) can improve relief of long-term knee pain caused by arthritis. If you qualify, you'll receive the RFA procedure and may be randomly assigned to also use VR.
Chicago, IllinoisAges 18 years+ - NCT06916676Recruiting
Laser therapy for knee osteoarthritis pain
This study tests a type of laser treatment called HILT to see if it can help reduce knee pain from osteoarthritis. You would attend 3 sessions each week for 4 weeks.
CairoAges 18–65 - NCT05981105Recruiting
Recovery and Chronic Pain After Knee Replacement
This study tests a special recovery program after knee replacement surgery to see if it helps reduce long-term pain. You may be eligible if you are having a first-time knee replacement for osteoarthritis, are between 18 and 65, and live near the hospital.
New York, New YorkAges 18–75 - NCT06650631Recruiting
Heat treatment for knee pain from arthritis
This study tests if a heat treatment device can help reduce knee pain caused by arthritis. It involves people with moderate pain who can walk without help and have a recent knee X-ray.
Gravesano, SwitzerlandAges 19–69 - NCT04199780Recruiting
Brain stimulation plus education to reduce pain after joint surgery
This study tests whether a non-surgical brain stimulation treatment combined with a structured education program can reduce pain after knee or hip replacement surgery. It may help some people feel less pain and recover more comfortably.
Charleston, South CarolinaAges 18–90 - NCT05986292RecruitingPhase 2
Study of new treatments for chronic pain
This study tests new treatments for chronic pain that lasts at least 3 months. Participants must stop their regular pain medicines and use only a rescue painkiller if needed. The goal is to find better ways to manage long-term pain.
Birmingham, AlabamaAges 18 years+ - NCT07281651Recruiting
Understanding pain sensitivity in knee pain and fibromyalgia
This study looks at how the brain and nerves process pain in people with knee pain or fibromyalgia. It compares them to pain-free people to understand differences in muscle signals.
Derby, DerbyshireAges 40 years+ - NCT06917404RecruitingPhase 3
Knee osteoarthritis pain study: comparing a new injection to placebo
This phase 3 study tests whether a medicine called pentosan polysulfate sodium (PPS), given as a shot under the skin, reduces pain in people with knee osteoarthritis. It compares PPS to a placebo (a shot with no active medicine) to see if it is safe and effective.
Peoria, ArizonaAges 18 years+ - NCT07625150Recruiting
PET/MRI Imaging Study of Kneecap Joint Osteoarthritis
This research study uses advanced imaging (PET and MRI scans) to better understand osteoarthritis in the front of the knee, where the kneecap meets the thighbone. You'll help researchers learn how to detect and track this condition earlier.
San Francisco, CaliforniaAges 18 years+ - NCT06808386Enrolling by invitation
How often should you train for knee pain relief?
This study looks at how different training frequencies affect knee pain recovery. It may help active adults who have had front knee pain for at least three months.
São Paulo, São PauloAges 18–40 - NCT07130630Recruiting
Pain and activity confidence in Vietnamese knee osteoarthritis
This study tests a questionnaire that measures how confident people with knee osteoarthritis feel about doing daily activities despite pain. Your answers will help doctors better understand and support Vietnamese-speaking patients.
Ho Chi Minh City, Ho Chi MinhAges 50 years+ - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06906939RecruitingEarly Phase 1
Brain stimulation and tai chi for knee arthritis and depression
This pilot study tests if combining brain stimulation (rTMS) with Tai Chi can help knee arthritis pain and improve depression. It compares these two treatments to see which works better for people with both pain and low mood.
Los Angeles, CaliforniaAges 50–95 - NCT07561333Recruiting
Pain Relief Methods for Knee Replacement Surgery
This study compares two different nerve-blocking anesthesia techniques to see which one controls pain better after knee replacement surgery. Both methods are designed to numb the area around your knee so you need less pain medication afterward.
Çorum, CentreAges 18–80 - NCT07003113Recruiting
Blood flow therapy for knee and back pain
This study tests a treatment called ischemic preconditioning, which uses a blood pressure cuff to temporarily restrict blood flow to your leg. It may help reduce pain from osteoarthritis in the knee or chronic back pain.
Chicago, IllinoisAges 50 years+
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Common questions
- Are there clinical trials for knee pain?
- Yes. Clin2 currently lists 180 recruiting knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.