Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06172010RecruitingPhase 4
Rifampicin plus antibiotics for staph joint replacement infection
This study tests whether adding the antibiotic rifampicin to standard treatment works better than standard treatment alone for staph infections in hip or knee replacements. The goal is to find a more effective way to clear the infection and avoid more surgeries.
Leiden, Zuid HollansAges 18 years+ - NCT06181097Recruiting
Negative pressure wound therapy after knee or hip replacement
This study tests whether using a special bandage that applies gentle suction (negative pressure wound therapy) after knee or hip replacement helps incisions heal better. It may reduce wound complications and improve recovery.
Hong KongAges 50 years+ - NCT07857967Recruiting
Stiff-knee walking after stroke compared with healthy walking
This study measures how thigh muscles and knee movements differ when people who had a stroke walk, compared with people without a stroke. It may help design better treatments for stiff-knee walking.
Luxembourg, LuxembourgAges 18 years+ - NCT07862907Recruiting
Comparing knee muscle recovery after two types of tibia nail surgery
This study compares two surgical methods for fixing a broken shin bone (tibia) to see if one leads to better knee muscle function. If you have a recent tibia fracture and are having surgery, this trial may help understand which approach might improve your recovery.
Istanbul, ŞişliAges 18–65 - NCT06249958Recruiting
Personalized rehabilitation after hip or knee replacement
This study looks at how personalized rehabilitation after hip or knee replacement surgery can improve your quality of life. It is for people who had their surgery at IRCCS Galeazzi Orthopedic Institute in 2019.
Milan, ItaliaAges 18 years+ - NCT07872670Recruiting
Virtual reality to help recovery after hip or knee replacement
This study uses virtual reality (a computer-generated 3D environment you wear a headset for) alongside your usual care to help with recovery after hip or knee replacement surgery. It may help reduce pain or improve how well you move after surgery.
Inverness, HighlandsAges 18 years+ - NCT06074744Recruiting
Nerve blocks for knee replacement pain relief
This study compares two types of nerve blocks (subsartorial and femoral) to see which provides better pain control after knee replacement surgery. Both are injections that numb the nerves around your knee to help with recovery.
LucerneAges 18 years+ - NCT06249906Recruiting
Bioceramic material for bone defect repair
This trial tests a new bioceramic material to repair bone defects. It is for adults aged 18 to 65 who are generally healthy and can follow the study plan.
Nanjing, JiangsuAges 18–65 - NCT05389410Recruiting
PICO dressings compared during repeat hip or knee surgery
This study compares two types of wound dressings (PICO 7 vs PICO 14) in people having a repeat (revision) hip or knee operation. It aims to see which dressing works better to help the surgical wound heal after surgery.
Oswestry, ShropshireAges 18 years+ - NCT06336447Recruiting
Virtual reality and nerve block for chronic knee pain
This study tests whether using virtual reality (VR) before a standard heat-based nerve block (radiofrequency ablation) can improve relief of long-term knee pain caused by arthritis. If you qualify, you'll receive the RFA procedure and may be randomly assigned to also use VR.
Chicago, IllinoisAges 18 years+ - NCT04912323Recruiting
Drug dissolving stent for blocked below-knee arteries
This trial studies a drug-eluting dissolving scaffold placed in blocked arteries below the knee to improve blood flow. It may help people whose leg circulation problems are severe enough to limit walking or threaten the limb, but only if their blockages fit specific imaging and procedure requirements.
GrazAges 18–90 - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT06426251Recruiting
Light therapy for knee replacement recovery
This trial tests whether a special light therapy (photobiomodulation) can help reduce pain and speed healing after total knee replacement. If you're having knee replacement and don't have complications like infection or open wounds, you may be eligible.
HsinchuAges 20 years+ - NCT07845695Recruiting
Music before joint replacement surgery to ease anxiety
This study tests whether listening to music just before hip or knee replacement surgery can help reduce anxiety. If you are having surgery for arthritis and are comfortable listening to music, you may be able to join.
New York, New YorkAges 18 years+ - NCT07845838Recruiting
Exercise training for knee osteoarthritis
This trial tests whether a structured exercise program can reduce oxidative stress in people with knee osteoarthritis, potentially helping to manage symptoms and improve joint health.
Capelle aan den IJsselAges 18 years+ - NCT07831200Recruiting
Taping and leg strengthening for knee pain
This study compares two types of tape (McConnell and Kinesio) combined with exercises to strengthen the hip and knee, to see which works better for people with pain in the front of the knee, especially when squatting or climbing stairs.
Islamabad, Punjab ProvinceAges 26–44 - NCT07817381Recruiting
Resistance and loading exercise for bone health
This trial tests a supervised exercise program with weights and jumping activities to improve bone health in males with one leg amputated below the knee. If you're already using a prosthetic leg and walking well, this study might help strengthen your bones.
LoughboroughAges 18–55 - NCT07810192Recruiting
Compression stockings for leg veins during long flights after surgery
This trial tests whether wearing a certain type of compression stocking during a long economy-class flight helps prevent veins in the legs from widening after plastic surgery. If you are planning such a trip, the study may help you recover more safely and comfortably.
BogotáAges 18–65 - NCT07815080Recruiting
Two ways to place knee replacement parts
This study compares two methods of aligning the thigh bone during knee replacement surgery. One method uses a guide inside the bone, the other uses a guide outside the bone. The goal is to see which gives better results and allows for a smoother recovery.
MilanAges 18 years+ - NCT07808931Recruiting
Long flight after cosmetic surgery: effect of seat class and compression stockings on leg vein swelling
This study looks at how different seating classes (business/first vs. economy) and wearing compression stockings on long flights affect leg vein swelling after cosmetic surgery. Participants will have an ultrasound to check the veins before and after the flight.
BogotáAges 18–65 - NCT07799818Recruiting
Joint replacement study for hip or knee
This study looks at how well hip or knee replacements work. If you are already scheduled for a replacement or a revision (a second replacement), you may be able to join.
Bonn, North Rhine-WestphaliaAges 18–100 - NCT07764354Recruiting
Patient education for sticking with home exercises
This study tests whether extra education helps people with chronic musculoskeletal conditions—like long-term back pain, knee arthritis, or partial rotator cuff tears—stick with their home exercise routines to feel better. If you have one of these conditions and are willing to follow a home exercise plan, this could help you manage pain.
Dammam, Eastern ProvinceAges Any age - NCT07763158Recruiting
Treatment for severe knee pain using artery embolization
This study tests a procedure that blocks tiny arteries in the knee to reduce pain from severe arthritis. It is for people who cannot have knee replacement surgery because of other health issues.
Jeddah, Mecca RegionAges 18 years+ - NCT07754214Recruiting
Exercise program for chronic heel pain
This study tests a supervised exercise program that combines balance (proprioception) and strengthening exercises to relieve chronic heel pain from plantar fasciitis. It may help improve foot function and reduce pain.
Karaman, KaramanAges 18–65
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.