Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04924205Recruiting
Smart knee brace rehab versus usual physical therapy
This trial compares recovery after primary knee replacement using a smart knee brace and app versus standard outpatient physical therapy. It may help you understand which rehab approach leads to better comfort and mobility during recovery.
Iowa City, IowaAges 18–100 - NCT04848896Recruiting
Safety and outcomes study of a smart knee replacement
This trial studies whether a “smart” knee replacement system (CORI) is safe and works well for people getting a total knee arthroplasty (TKA). If you’re a good candidate for a cemented standard knee replacement, the study follows you for two years to check results after surgery.
EppingAges 18 years+ - NCT04752761Recruiting
Digital tracking after knee replacement for people with severe knee arthritis
This study checks whether using digital tools (like a phone app or tablet) can better track patient-reported outcomes after knee replacement, compared with usual outpatient follow-up. It may help improve how symptoms and recovery are monitored, which can guide care.
Bologna, ItaliaAges 18–78 - NCT04432012RecruitingPhase 4
Compare steroid shots versus other delivery after knee replacement
This study compares different ways of giving steroid medicine after a total knee replacement to see which approach works best and is well-tolerated. You may qualify if you’re getting a first (not repeat) knee implant and can follow the study steps.
LuganoAges 50–85 - NCT04472702Recruiting
Ultrasound vs X-ray guidance for knee pain ablation
This trial compares two ways (ultrasound or X-ray guidance) to place a treatment for painful knee arthritis. It aims to see whether one guidance method works as well as the other for reducing knee pain.
Sacramento, CaliforniaAges 35–99 - NCT04145401Enrolling by invitation
Long-term follow-up for a specific knee revision implant
This study tracks how well a particular knee revision implant performs over many years. It may help you by closely monitoring your knee after revision surgery and adding to long-term safety and performance data.
Englewood, ColoradoAges 21 years+ - NCT04134702Recruiting
Acupuncture for less pain after outpatient knee surgery
This study tests whether acupuncture can reduce pain after outpatient arthroscopic knee surgery done under general anesthesia. It may help by improving pain control while avoiding certain medicine side effects, but you must meet several specific safety and medication limits.
Greifswald, VorpommernAges 19–55 - NCT03932838Recruiting
Study of knee ligament reconstruction outcomes after injury
This study looks at how people do after one-time surgery to repair multiple knee ligaments using either donor tissue or their own tissue. It helps doctors better understand what to expect after multiligament knee reconstruction.
Le ChesnayAges 18 years+ - NCT03858231RecruitingPhase 4
Opioid vs non-opioid pain relief after knee arthroscopy
This study compares opioid pain medicine with non-opioid pain medicine after arthroscopic (keyhole) knee surgery. It aims to see which approach controls pain well while keeping side effects and risks lower.
Fargo, North DakotaAges 18–80 - NCT03734900RecruitingPhase 4
Comparing two knee injection treatments for osteoarthritis
This study compares two knee injection treatments for knee osteoarthritis. It aims to see which one works better for reducing pain and improving function, so you might experience less knee pain and better mobility.
TaipeiAges 50–80 - NCT03588975RecruitingPhase 3
Cartilage repair for knee damage in teens
This trial tests two ways to repair damaged knee cartilage in young people: one uses your own cartilage cells grown in a lab (MACI), and the other is a standard procedure called microfracture. The goal is to see which works better to reduce pain and improve knee function, and to help you get back to normal activities.
Palo Alto, CaliforniaAges 10–17 - NCT03711773Recruiting
Low-impact exercise classes for joint pain
This study tests a gentle, low-impact exercise program to improve pain and function for adults with knee, ankle, and/or hip pain. You’ll also attend dietitian and behavioral health classes as part of standard care while you participate.
Columbia, MissouriAges 18 years+ - NCT02890485Recruiting
Dry needling for knee pain with stair or squat pain
This study tests whether dry needling can reduce ongoing knee pain in people who feel pain around the kneecap when going up or down stairs, squatting, or running. You may be able to join if your knee pain has lasted at least 3 months and you’re referred to physical therapy.
Columbus, OhioAges 18–40 - NCT02692092Recruiting
Records for your hip or knee replacement care
This registry collects information about people who have a hip or knee replacement at a HealthEast hospital. It helps researchers and the hospital system understand outcomes and improve care.
Saint Paul, MinnesotaAges 18 years+ - NCT02511158Recruiting
Knee ligament surgery study after ACL reconstruction
This study follows people who have a knee ligament tear and undergo surgery to rebuild the ligament. It may help doctors better understand recovery and outcomes after different surgical techniques.
ParisAges 7 years+ - NCT03328611Recruiting
Joint replacement outcomes database for degenerative joint disease
This study collects information about people with “wear-and-tear” joint disease who need joint replacement. The goal is to better understand outcomes after surgery and improve future care.
Indianapolis, IndianaAges Any age - NCT03096366Recruiting
Blood flow restriction rehab after ACL knee surgery
This trial studies whether a special exercise method that limits blood flow to the thigh (called blood flow restriction training) can improve quadriceps strength and function during recovery after arthroscopic ACL surgery. If you qualify, you would join a structured physical therapy program and follow the study’s rehab plan.
Houston, TexasAges 14–55 - NCT05461651Recruiting
Preventing knee infections after knee replacement
This study looks at ways to lower the risk of infection after knee replacement surgery (with or without vancomycin, an antibiotic). If you’re a good candidate, you may receive an approach aimed at preventing post-surgery infections and related complications.
Otwock, Masovian VoivodeshipAges 40 years+ - NCT05599776Recruiting
Smart ring-guided rehab after knee replacement surgery
This study tests whether using a smart ring along with physical therapy after knee replacement helps people recover better. It mainly looks at people’s rehab progress in the weeks after surgery.
Tampere, PirkanmaaAges 18–70 - NCT05685706Recruiting
Study of spine alignment after hip or knee replacement
This study looks at how the alignment of your spine relates to your walking and posture after hip or knee replacement surgery for wear-and-tear arthritis. It may help doctors better understand how to monitor recovery and long-term function.
Taichung, North DistrictAges Any age - NCT04607538Recruiting
Study of knee joint shape and patella dislocations in Faroese teens
This study looks at how knee joint shape differences may relate to repeated kneecap (patella) instability or near-dislocation, and what that means long-term. It specifically includes teens from the Faroe Islands and asks about symptoms and knee function over time.
HvidovreAges 15–20 - NCT04236492Recruiting
Fresh cartilage graft study for large knee joint damage
This trial studies how well a fresh cartilage and bone graft works to repair large, full-thickness defects in the knee. It also looks at imaging results (pictures of the knee) to see how the repair is healing over time.
Barcelona, CataloniaAges 15–50 - NCT02257723Recruiting
Testing combined Korean herbal and therapy for hospitalized spine or joint pain
This trial studies whether a combined complementary treatment approach helps people who are hospitalized for spine or joint problems. It may help reduce the types of pain that come from those areas.
Seoul, Gangnam-GuAges Any age - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.