Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06856356Recruiting
Robot-assisted knee replacement surgery study
This study tests if robot-assisted total knee replacement surgery is safe and effective. It may help people who need knee replacement surgery by using advanced technology for more precise implant placement.
Hefei, AnhuiAges 18–80 - NCT07348614RecruitingPhase 4
Knee manipulation: best numbing method for less pain
This study tests different numbing techniques to see which works best for pain during a knee manipulation procedure. It may help you have less pain and a smoother recovery.
Durham, North CarolinaAges 18–75 - NCT07347821Recruiting
Study of osteoarthritis in hip and knee replacement patients
This study looks at why osteoarthritis happens in the hip and knee by studying tissue samples taken during joint replacement surgery. If you are already scheduled for a first-time hip or knee replacement and have osteoarthritis, you may be able to join.
Ostrów Mazowiecka, Masovian VoivodeshipAges 18 years+ - NCT06858358Recruiting
Robot vs. standard knee replacement for severe arthritis
This trial compares a robot-assisted knee replacement technique to the standard approach for people with severe knee arthritis. It aims to see which method leads to better recovery and outcomes.
Cluj-Napoca, ClujAges Any age - NCT07324954RecruitingPhase 1
Methylene blue for knee replacement surgery
This study tests if using a blue dye called methylene blue during knee replacement surgery can help doctors see and clean out infections better. It may help people having a first-time knee replacement or those with an infected knee replacement.
Miami, FloridaAges 18 years+ - NCT07329023Recruiting
Acupressure for Knee Arthritis in Older Chinese Adults
This trial tests whether learning self-administered acupressure (a type of massage using fingertips) can help older Chinese adults with knee arthritis manage their pain and stiffness without medication. If you join, you will receive training in a community setting and use a smartphone app to track your progress.
KowloonAges 60 years+ - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07324109Recruiting
Testing a system for phantom limb pain after leg amputation
This trial is testing a system called Suralis to see if it can help evaluate phantom limb pain — pain that feels like it's coming from a missing leg. It's for people who have had a leg amputated below or above the knee, use a prosthetic regularly, and have daily pain scoring at least 3 out of 10.
Wiesbaden, HesseAges 18 years+ - NCT07318116Enrolling by invitation
Cabbage Leaf for Knee Osteoarthritis Pain
This study tests whether applying cabbage leaves to the knee can reduce pain in people with knee osteoarthritis. If you have had knee pain for at least 6 months and are not allergic to cabbage, you may be able to join.
Şirnak, MerkezAges 18–80 - NCT06875817Recruiting
Feldenkrais exercises for knee osteoarthritis pain
This study tests if gentle, slow Feldenkrais movement exercises can reduce knee pain and improve mobility in people with moderate knee osteoarthritis. It is designed for those who are still able to walk and get up from the floor, but are experiencing significant pain.
Lahore, Punjab ProvinceAges 40–60 - NCT07246109Enrolling by invitation
Knee Brace and Muscle Training for Osteoarthritis
This study tests whether wearing a knee brace and doing muscle training exercises can help people with knee osteoarthritis feel better and move more easily. It may be a good option if you have not had knee surgery and are not already in another treatment program.
TaichungAges 55 years+ - NCT07239258Recruiting
Tele-rehab plan for knee replacement recovery
This study tests a special therapy plan delivered through video calls to help people recover after knee replacement surgery. It compares telerehabilitation to in-person therapy to see if it improves pain and movement.
Lahore, Punjab ProvinceAges 50–65 - NCT06896032Recruiting
Walking backward vs forward on an underwater treadmill for knee osteoarthritis
This study compares walking backward versus walking forward on an underwater treadmill to see which helps reduce pain and improve function in people with knee osteoarthritis. It may be a good fit if you have mild to moderate knee OA in one knee and are between 40 and 60 years old.
Cairo, Cairo GovernorateAges 40–60 - NCT07183475Recruiting
Returning to sports after knee replacement
This study looks at how well people can get back to sports after having a knee replacement. If you have had a knee replacement and are active in sports, you may be able to join to help researchers learn more about recovery.
Munich, BavariaAges 18–85 - NCT07161336RecruitingPhase 2
Methotrexate for knee arthritis with swelling seen on ultrasound
This trial tests if methotrexate (a medicine that reduces inflammation) can improve knee pain and swelling in people with knee osteoarthritis. It is for patients who have signs of synovitis (inflammation inside the joint) that can be seen on an ultrasound.
Dhaka, Dhaka DivisionAges 40–70 - NCT07130630Recruiting
Pain and activity confidence in Vietnamese knee osteoarthritis
This study tests a questionnaire that measures how confident people with knee osteoarthritis feel about doing daily activities despite pain. Your answers will help doctors better understand and support Vietnamese-speaking patients.
Ho Chi Minh City, Ho Chi MinhAges 50 years+ - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07123805Recruiting
Acupuncture for knee replacement recovery
This study tests if adding acupuncture before and after knee replacement surgery helps reduce pain and improve recovery. It may be an option for people having planned knee replacement for osteoarthritis.
Pavia, PaviaAges 18 years+ - NCT06969222Recruiting
Robotic knee replacement study with a special implant
This study tests a robot-assisted knee replacement using a new type of implant designed to move more like a natural knee. It may help people with arthritis or other knee joint problems who need a total knee replacement.
Larissa, ThessalyAges 18–95 - NCT07080814Recruiting
Balance exercises after knee replacement
This study tests whether special balance exercises on a platform can help people who have recently had a knee replacement walk better and feel steadier.
Ankara, YenimahalleAges 18 years+ - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT06466330Recruiting
Knee embolization for post-replacement pain
This trial tests a non-surgical treatment called microparticle geniculate artery embolization for people with persistent knee pain after a total knee replacement. It aims to reduce pain by blocking tiny blood vessels that may be causing inflammation.
CréteilAges 40–80 - NCT07013019Recruiting
Normal knee rotation in athletes
This study measures normal knee rotation in athletes who play sports with pivoting movements. It helps doctors understand what healthy knee motion looks like, so they can better diagnose injuries.
Toulon, VarAges 15 years+ - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.