Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06930677Recruiting
Knee osteoarthritis treatment study using embolization
This trial tests a new treatment called embolization using a special material (NBGM200) to block certain blood vessels in the knee. It may help reduce pain and improve function in people with knee osteoarthritis.
GhentAges 50 years+ - NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+ - NCT06916728Enrolling by invitation
10-year knee implant follow-up study
This study follows patients who already took part in a previous trial for a knee implant (MP01). It checks how well the implant is working over 10 years compared to standard knee surgery.
La Mesa, CaliforniaAges 21–75 - NCT06845553RecruitingPhase 2
Vutiglabridin for knee osteoarthritis: a phase 2 study
This trial tests an experimental pill called Vutiglabridin for people with knee osteoarthritis. It aims to see if the drug is safe and effective at reducing knee pain and improving function.
Seongnam-si, Gyeonggi-doAges 40–75 - NCT06782529RecruitingPhase 4
Knee injection study for patients with obesity and arthritis
This study tests if steroid injections for knee arthritis work in people with obesity. It may help you manage pain and avoid surgery.
Jacksonville, FloridaAges 55–85 - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT06617975Recruiting
Spa therapy for knee arthritis
This trial tests whether spa therapy (balneotherapy) can help people with knee osteoarthritis. You would receive treatment at the Santenay spa as part of your regular care.
Santenay, BurgundyAges 50–80 - NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06634654Recruiting
AI-guided knee replacement study
This trial tests whether using artificial intelligence can improve recovery from total knee replacement by tailoring care to your body's needs. It may help people with severe knee arthritis who have not had major knee surgery before.
Rome, ItalyAges 18 years+ - NCT06608745Recruiting
Computer-assisted vs standard knee replacement study
This trial compares a computer-assisted technique to the standard method for total knee replacement. It aims to see if the computer-assisted approach leads to better clinical and functional outcomes.
BolognaAges 45 years+ - NCT06617871Recruiting
Comparing two ways to align a new knee replacement
This study compares two different techniques (mechanical alignment vs. kinematic alignment) used during knee replacement surgery with a special knee system. It aims to see which technique leads to better results for patients.
Chicago, IllinoisAges 21–79 - NCT06611618Recruiting
Predicting fall risk in knee osteoarthritis using muscle tests
This study looks at how loss of muscle strength and control in people with knee osteoarthritis can predict falls. It uses tests and MRI to understand your risk, with the goal of helping prevent future falls.
BolognaAges 65–80 - NCT06525610Recruiting
CT scan study for knee fracture repair after replacement
This study uses a special weight-bearing CT scan to look at how your new knee replacement and the bone around it heal after surgery to fix a broken bone just above the knee. It may help doctors understand how well the repair holds up when you put weight on it.
London, OntarioAges 50–90 - NCT06447922Enrolling by invitation
Metal Levels After Knee Replacement
This study measures metal levels in the blood after knee replacement surgery. It may help researchers understand how metal from the new joint affects the body.
Rochester, MinnesotaAges 18–100 - NCT06419920Recruiting
Prosthetic performance enhancement trial
This study tests whether a new prosthetic foot can help people with a lower-limb amputation walk better. You will use your current foot and the new foot, and we will measure how well you walk.
Las Vegas, NevadaAges 18 years+ - NCT06298721Recruiting
Personalized care to improve knee replacement satisfaction
This study tests a personalized approach to knee replacement surgery designed for people who are at higher risk of being dissatisfied after the procedure. The goal is to see if tailoring care based on patient-reported outcomes can improve satisfaction.
Cleveland, OhioAges 18–80 - NCT06293352Recruiting
Comparing two antibiotic spacers for knee infection
This trial compares two types of antibiotic spacers for people with a long-term knee replacement infection. It tests whether a spacer made entirely of antibiotic cement or one with a metal core works better to treat the infection before a new knee replacement.
Chicago, IllinoisAges 18 years+ - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06251752Recruiting
Long-term study of kneecap after knee realignment surgery
This study looks at how well the kneecap joint holds up many years after a knee realignment surgery (high tibial osteotomy) for inner knee arthritis. If you had this surgery more than 5 years ago, you may be able to join a long-term checkup that uses X-rays and medical records to see how your knee is doing.
BolognaAges 18–65 - NCT06218238Recruiting
Testing the power knee for above-knee amputees
This study tests a powered knee called the Ossur Power Knee to see how it affects walking for people who have had an above-the-knee amputation. It might help you walk more smoothly and with less effort.
Chicago, IllinoisAges 45–75 - NCT06208631Recruiting
Movement retraining for knee osteoarthritis pain
This study tests a movement retraining program to see if changing how you walk can reduce stress on your knee and ease osteoarthritis pain. It’s a good fit for people with mild knee pain who want a non-surgical option.
Stanford, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.