Clinical trials
Knee clinical trials
Below are recruiting knee clinical trials, each written for real people, not researchers. We’re tracking 814 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT05928403Recruiting
Compare knee implant types by how well people return to sport
This study compares three types of knee replacement implants to see how quickly and how well people can return to sports. It may help doctors understand which implant design supports better movement and recovery.
BiarritzAges 18–70 - NCT05876143Recruiting
Study of a knee implant with patient follow-up surveys
This trial follows people who already have (or are receiving) a specific partial knee implant to see how they do over time using questionnaires after surgery. It may help improve care for future patients with knee arthritis who get this type of implant.
Pierre-BéniteAges 18 years+ - NCT05848622Recruiting
Gait retraining after ACL surgery for fast knee recovery
This trial tests a walking (gait) rehabilitation program to improve how you move after ACL reconstruction. It may help if you are still having walking mechanics issues in the months to years after surgery.
Chapel Hill, North CarolinaAges 16–35 - NCT05642260Recruiting
Fall-prevention program after knee replacement for older women
This trial tests whether a structured fall-prevention program can reduce the number of falls in older women after total knee replacement surgery. It may help you stay safer as you recover and move around.
Kuwait CityAges 60 years+ - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT04992624RecruitingPhase 2
Cannabinoid treatment effects on knee pain and nerve signals
This Phase 2 study tests whether a cannabinoid-related treatment changes how pain works in people with knee osteoarthritis. It uses questionnaires, MRI, and gentle nerve testing to understand if treatment helps pain and pain-related signals.
Ann Arbor, MichiganAges 21–75 - NCT03869996Recruiting
Fast-track recovery for knee replacement patients
This trial studies a faster recovery “fast-track” plan for people getting their first total knee replacement for arthritis. It may help by getting you back to movement and normal life sooner, while comparing outcomes against usual care.
BolognaAges 18–78 - NCT07219771RecruitingPhase 3
Knee injection for osteoarthritis pain
This study tests a single injection of PTP-001 (MOTYS™) into the knee to see if it reduces osteoarthritis pain. It is for people whose knee pain is their main pain problem and who haven't found relief from standard pain medicines.
Birmingham, AlabamaAges 40–80 - NCT07869615Recruiting
Blood thinners after knee replacement surgery
This study compares two types of blood thinners to prevent blood clots after knee replacement surgery. It will help find which one works better and is safer for patients.
Tunis, Tunis GovernorateAges 18–80 - NCT07875296Recruiting
Enzyme levels in knee arthritis
This study looks at certain enzymes in the blood of women with knee osteoarthritis. It may help doctors understand how arthritis works and could lead to better treatments.
AfyonkarahisarAges 40–70 - NCT06096259RecruitingPhase 2
Preventing knee arthritis after ACL injury
This trial tests whether metformin, a common diabetes medicine, can prevent arthritis after an ACL injury. If you are planning to have ACL surgery soon, you may be able to join.
Atlanta, GeorgiaAges 18–45 - NCT04230616Recruiting
Testing a knee device to ease osteoarthritis pain
This study tests how well and how safely a knee treatment works for adults with painful knee osteoarthritis seen on X-ray. You might join if you need meaningful pain relief and help with daily function, and can complete required scans and study instructions.
Sint-Truiden, LimburgAges 18 years+ - NCT04960098Recruiting
Survey after hip or knee replacement surgery
This study asks people who have had a hip or knee replacement to share how they’re doing over time. It’s testing whether patient-reported survey answers can help measure recovery and outcomes.
MilanAges 18 years+ - NCT04716803Recruiting
BMAC injection for severe knee osteoarthritis before knee surgery
This trial studies injecting “bone marrow aspirate concentrate” (BMAC) into the knee to help relieve pain from severe knee osteoarthritis. It’s for people who have strong signs of advanced arthritis on X-ray and still have ongoing pain despite usual treatments, before a planned knee procedure.
La Jolla, CaliforniaAges 45–75 - NCT04446676Recruiting
Stabilization method after staged knee revision for infection risk
This study compares two ways of stabilizing a knee implant after a two-step (staged) knee revision to see which better prevents reinfection. It may help people trying to avoid another infection after treatment of a previously infected knee implant.
Otwock, Masovian VoivodeshipAges 18–90 - NCT05314608Recruiting
Testing IOBP treatment for knee bone lesions seen on MRI
This trial studies whether an IOBP® procedure can reduce knee pain in adults with a specific bone lesion under the joint surface. It focuses on people whose MRI shows one target lesion and who are already planned for IOBP surgery.
Denver, ColoradoAges 18–60 - NCT05936814Recruiting
Study measures knee alignment in severe varus osteoarthritis
This study focuses on people age 65+ with severe “varus” knee alignment osteoarthritis (wear-and-tear arthritis that affects how the knee lines up). It aims to use your knee measurements and data to better understand the condition and guide care.
AnkaraAges 65 years+ - NCT05887440Recruiting
Isokinetic strength training for knee control after stroke
This trial studies whether a special strength-training program that uses an “isokinetic” machine can improve walking and knee control in people after stroke. It is for people who have noticeable knee movement during walking and can safely take part in rehab.
RennesAges 18–75 - NCT05729061Recruiting
Testing movement with mobility assistive devices
This study measures how people move while using assistive devices during guided movement tasks, sometimes on a treadmill. It may help improve these tools and how safely they support different types of movement needs.
Edmonds, WashingtonAges 18–90
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Common questions
- Are there clinical trials for knee?
- Yes. Clin2 currently lists 814 recruiting knee studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a knee trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a knee trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.