Clinical trials
Limb Loss clinical trials
Below are recruiting limb loss clinical trials, each written for real people, not researchers. We’re tracking 14 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05729061Recruiting
Testing movement with mobility assistive devices
This study measures how people move while using assistive devices during guided movement tasks, sometimes on a treadmill. It may help improve these tools and how safely they support different types of movement needs.
Edmonds, WashingtonAges 18–90 - NCT06908538Recruiting
Cryo nerve block for pain after amputation
This study is testing a treatment called a cryo nerve block to reduce pain after amputation, including phantom limb pain. It will look at whether freezing the nerve during surgery helps people feel less pain and use less pain medicine.
Pittsfield, MassachusettsAges 18 years+ - NCT06218238Recruiting
Testing the Ossur Power Knee for above-knee amputees
This study tests a new bionic knee called the Ossur Power Knee for people with an above-knee amputation. It looks at how well the knee helps with walking and balance, which may lead to better mobility.
Chicago, IllinoisAges 45–75 - NCT05818410Recruiting
Brain and tech training after below-knee leg loss
This study looks at how your brain works with assistive technology after losing a leg below the knee. It may help researchers improve how prosthetic devices feel and function by measuring brain and movement signals during training.
BrusselsAges 18–65 - NCT05888428Recruiting
Test of a smart arm prosthesis control system for arm amputees
This trial studies whether the MyoTrain system can help people with a below-elbow (trans-radial) arm amputation control a myoelectric prosthesis using muscle signals. It may help you practice and use a more “thought-to-movement” style control method if you meet the safety and participation requirements.
Grand Rapids, MichiganAges 18 years+ - NCT04883502Recruiting
Testing a technique to rebuild bone lost after injury
This study looks at a surgical method that creates an “induced membrane” to help rebuild bone after traumatic injury. It may help people whose limb bones were damaged and are missing part of the bone.
ClamartAges 18 years+ - NCT06043518Recruiting
Brain changes after losing an arm or hand
This study uses MRI scans to see how the brain changes in people born without a hand or who lost an arm. You might join as a participant with upper-limb loss or as a healthy volunteer for comparison.
Zurich, Canton of ZurichAges 18–75 - NCT05831696Recruiting
Compare walking effort with two types of prosthetic knees
This trial studies how much energy it takes to walk when using passive versus powered prosthetic knees. It may help people understand which knee type could make walking feel easier depending on their needs.
Loma Linda, CaliforniaAges 18–75 - NCT02310867RecruitingPhase 2
Immunotherapy to help grafts heal for people with limb loss
This Phase 2 study tests an immune-targeting treatment to help a transplanted tissue “graft” integrate and heal better after limb loss. It may help by reducing problems with healing and rejection, but you must be able to complete frequent follow-up visits and testing.
Durham, North CarolinaAges 18–65 - NCT07418645Recruiting
Touch feedback system for arm amputees
This study tests a new system that gives you touch sensations through a prosthetic hand. It aims to help you feel more connected to the device and improve how you use it.
Pisa, PIAges 18–80 - NCT04449211RecruitingEarly Phase 1
3D-printed implant for large bone defects
This trial studies whether a custom 3D-printed implant helps heal a large bone defect after injury or tumor removal. If you have a bone gap bigger than 5 centimeters and can safely have surgery, this may be a treatment option being tested.
Ho Chi Minh CityAges 18 years+ - NCT04112992Recruiting
Registry for post-injury long bone bone defects
This study is a registry that collects real-world information about adults with bone gaps in the long bones caused by injury. It may help researchers understand what treatments work best and improve care for these defects over time.
Los Angeles, CaliforniaAges 18 years+ - NCT07461701Recruiting
Comparing two squat intensities for strength in young women
This study compares two ways of doing bodyweight squats (stopping when you lose 15% vs 30% of your speed) to see which is better for building leg strength and endurance in young women who are not very active. It may help find a simple, safe way to improve fitness at home.
Lahore, Punjab ProvinceAges 18–25 - NCT04841057Enrolling by invitation
Study of blood and stool changes after weight-loss surgery
This study looks at how your body’s metabolism changes after a specific weight-loss surgery (gastric bypass). It may help researchers better understand what to expect and how to tailor care, while requiring blood draws and stool samples before and after surgery.
Columbia, MissouriAges 18–80
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Common questions
- Are there clinical trials for limb loss?
- Yes. Clin2 currently lists 14 recruiting limb loss studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a limb loss trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a limb loss trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.