Clinical trials
Weight Loss clinical trials
Below are recruiting weight loss clinical trials, each written for real people, not researchers. We’re tracking 195 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06785064Recruiting
Helping with long-term weight loss maintenance support
This study tests an extended care program designed to help people keep weight off after losing it. You would join with a buddy (friend or family member) and attend online sessions via Zoom, along with a few in-person check-ins at the university.
Birmingham, AlabamaAges 18 years+ - NCT05799846Recruiting
Online strategies to help with weight loss
This study tests a cognitive (thinking-focused) approach delivered through the internet to help you lose weight. You may be eligible if you have overweight or obesity and can regularly complete online activities and visits.
Providence, Rhode IslandAges 18–70 - NCT05748158Recruiting
Study of why weight returns after behavioral weight loss
This study looks at what makes some people regain weight after losing weight in a behavioral weight loss program. You may help researchers understand the role of habits, metabolism, and energy use so better prevention strategies can be developed.
New York, New YorkAges 25–59 - NCT05775497Recruiting
Online weight-loss program for sexual minority women
This study tests an online weight-loss program, with added culturally tailored parts, for sexual minority women who want to lose weight. It may help by coaching healthier habits through email and internet tools.
Providence, Rhode IslandAges 18–70 - NCT06776081Recruiting
Weight loss, fat cell particles, and blood vessel health
This trial looks at how weight loss changes tiny particles released from fat cells and whether that improves blood vessel function. It may help understand how losing weight can protect your heart.
Boulder, ColoradoAges 40 years+ - NCT06809166RecruitingPhase 4
Contrave for weight loss in adults with obesity
This study tests whether a weight loss medication called Contrave can help adults with obesity lose weight by changing how their body uses energy and handles food. If you qualify, you will take Contrave and be monitored for several months.
Ottawa, OntarioAges 18–64 - NCT06875622Recruiting
Online weight loss program for better health
This study tests an online program to help people lose weight by making healthy lifestyle changes. It's designed for people who have daily internet access and a BMI between 25 and 45.
Providence, Rhode IslandAges 18 years+ - NCT06961591Recruiting
Cooking skills for long-term weight loss in young adults with ID
This program teaches cooking skills to help young adults with intellectual disabilities lose weight and keep it off for 2 years. You’ll learn to prepare healthier meals with support from a family member or caregiver.
Kansas City, KansasAges 18–35 - NCT07118904Recruiting
How dehydration affects sleep, thinking, and muscles in combat athletes
This study looks at how losing fluid (dehydration) impacts your sleep, thinking ability, and muscle signals. It may help explain how rapid weight loss affects combat athletes like you.
BoluAges 17–28 - NCT07190170Recruiting
Time-Restricted Eating for Weight Loss Maintenance
This study tests whether a time-restricted eating schedule (when you eat all your meals within a certain window each day) helps people keep off weight they've recently lost. Using a smartphone app, you'll log your meals and follow a daily eating window to see if it helps you maintain your weight loss.
New York, New YorkAges 25–65 - NCT07577765Recruiting
Keeping Weight Off With a Personalized Plan
This study tests a customized approach to help you maintain weight loss you've already achieved. Researchers will use your smartphone to send you tailored support and track your progress over time.
Salt Lake City, UtahAges 18–65 - NCT05798494Recruiting
Pre-pregnancy weight loss plan to protect child weight
This study tests whether a very low-calorie weight loss program before pregnancy can improve the chance that a child will have a healthier weight later. It follows families and stores samples from the child at home.
AarhusAges 18–38 - NCT03866408RecruitingEarly Phase 1
Testing how insulin affects fat breakdown proteins
This early study looks at how insulin changes the body’s fat breakdown and related proteins. You might join if you’re within a certain body-weight range and can safely take the study medication.
Rochester, MinnesotaAges 18–55 - NCT06949280Recruiting
Peanuts, weight loss, and bone health study
This study tests whether eating peanuts daily during weight loss affects bone health in adults aged 50 to 75.
New Brunswick, New JerseyAges 50–75 - NCT05518604Recruiting
Weight loss and fitness after pregnancy in active-duty women
This study looks at how to support healthy weight loss and physical fitness after having a baby while you’re still on active duty. It may help by testing a structured approach to fitness and planning during the first 18 months after delivery.
Honolulu, HawaiiAges 18–44 - NCT06230744Recruiting
A weight loss program for young adults using a smartphone app
This study tests a new weight loss program designed specifically for young adults ages 18 to 40. You will use a smartphone app to help you lose weight, and the study will see if the program works well for people in your age group.
Chicago, IllinoisAges 18–40 - NCT06174389Recruiting
Weight loss study: diet, appetite and body changes
This study looks at how diet, appetite, and body changes work together during weight loss. It's designed for people with a BMI of 30 to 50 who want to lose weight and are not taking certain medications or have certain health conditions.
Seattle, WashingtonAges 18–60 - NCT06428617Recruiting
Stomach ablation treatment for weight loss
This trial studies a new stomach procedure called fundus ablation to help with weight loss. The doctor uses a device to treat the upper part of your stomach, and you'll follow a special diet long-term.
Cary, North CarolinaAges 18–65 - NCT06602622RecruitingPhase 4
Weight change study for people with HIV switching to DOR/3TC/TDF
This study tests whether switching your HIV medication to a combination called DOR/3TC/TDF can help with weight changes that started after taking another type of HIV drug (integrase inhibitor). It is for people who have gained weight unintentionally and want to see if a different medication helps manage it.
Mexico City, AzcapotzalcoAges 18–80 - NCT07229170Recruiting
Taste changes and eating habits on weight loss drugs
This study looks at how GLP-1 medications (like semaglutide/Wegovy or tirzepatide/Mounjaro) change your sense of taste and eating habits while losing weight. If you are 18–60, have obesity, and have been taking one of these drugs for at least 12 weeks, you may qualify.
Roma, ItalyAges 18–60 - NCT06998758RecruitingPhase 3
Megestrol Acetate for weight loss during chemo in advanced colorectal cancer
This trial tests if taking megestrol acetate (a medicine used to stimulate appetite and help gain weight) can reduce weight loss caused by chemotherapy in people with locally advanced colorectal cancer. It may help you maintain strength and energy during treatment.
Guangzhou, GuangdongAges 18–75 - NCT04228978Recruiting
Lifestyle weight-loss program for people with PAD to stay mobile
This trial tests whether a healthy-lifestyle weight-loss program can help people with peripheral artery disease (PAD) lose weight and prevent worsening mobility. You may be eligible if you have PAD based on specific leg blood-flow test results and a higher body weight.
Chicago, IllinoisAges 18 years+ - NCT06861790Recruiting
How weight loss surgery affects brain function
This study looks at how weight-loss surgery affects brain function. You will have an MRI scan and give a small blood sample before and after surgery.
Gainesville, FloridaAges 20–75 - NCT05750732Recruiting
Study weight loss and a gene variant
This trial looks at how weight loss relates to a specific gene difference (CLOCK 3111T/C). You may be eligible if you’re in a certain age and body-mass range and don’t have conditions or medicines that could affect weight or metabolism.
AnkaraAges 20–50
Hear when a new Weight Loss trial opens
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Weight Loss trials by city
Studies with a site in or near these metro areas.
Weight Loss trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for weight loss?
- Yes. Clin2 currently lists 195 recruiting weight loss studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a weight loss trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a weight loss trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.