Clinical trials
Critical Limb Ischemia clinical trials
Below are recruiting critical limb ischemia clinical trials, each written for real people, not researchers. We’re tracking 29 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04312451Recruiting
Study of severe leg blood-flow problems after a procedure
This study follows adults with very poor blood flow to the foot or leg (with wounds or severe pain) who are having a revascularization procedure to improve circulation. It may help doctors understand outcomes after treatment and improve care for people with critical limb ischemia.
ParisAges 18 years+ - NCT05313165Recruiting
Stent procedure for poor blood flow in the leg ulcers and gangrene
This trial tests a new minimally invasive procedure (placing a small stent) to improve blood flow to a severely threatened foot or lower leg. It may help people whose ulcers or gangrene are not treatable with standard bypass or other surgeries.
La Jolla, CaliforniaAges 18–95 - NCT05830721Recruiting
Monitoring leg pressure in adults on life-support
This trial tests a device that continuously measures pressure in an arm or leg to help detect compartment syndrome in people on a heart-lung machine (VA-ECMO). It may help clinicians act sooner if pressure becomes dangerous, potentially reducing complications.
Baltimore, MarylandAges 18 years+ - NCT05854641RecruitingPhase 4
Stem cell treatment for poor blood flow in the leg ulcers
This trial tests whether a stem cell product (Stempeucel®) can improve healing and safety for people with critical limb ischemia caused by peripheral artery disease. It is for patients who cannot have (or have already tried) procedures to reopen blocked leg arteries and who have a leg ulcer and low blood-flow measurements.
Kuala LumpurAges 18–65 - NCT05854615RecruitingPhase 4
Stem cell treatment for painful poor blood flow in limbs
This trial tests whether a stem cell product (Stempeucel®) is safe and effective for people with Buerger’s disease causing critical limb ischemia and foot ulcers. It may help improve healing and blood flow when other options may be limited.
Kuala LumpurAges 18–65 - NCT06066268Recruiting
miRNAs in Critical Limb Ischemia Study
This study looks at small molecules called miRNAs in the blood of people with severe leg artery disease (critical limb ischemia) or belly aortic aneurysm. The goal is to find patterns that may help doctors better understand and treat these conditions.
San Donato Milanese, MilanAges 40–85 - NCT06075940Recruiting
A dissolving stent for blocked leg arteries below the knee
This study tests a new bioresorbable scaffold (like a temporary mesh) that slowly dissolves, releasing medication to keep your below-the-knee artery open. It is for people with severely blocked leg arteries causing pain or wounds at rest (Rutherford 4 or 5).
Randwick, New South WalesAges 18 years+ - NCT06174597RecruitingEarly Phase 1
Stem cells for critical limb ischemia treatment
This trial tests whether stem cells from umbilical cord arteries can help people with severe leg pain or ulcers due to blocked arteries. It is for those who cannot have surgery or other procedures.
Nanjing, JiangsuAges 18–80 - NCT06238050Recruiting
Oxygen therapy for severe leg artery disease
This trial tests whether breathing pure oxygen at normal pressure can help people with severe, long-lasting lack of blood flow in their legs. It may offer a way to improve oxygen delivery to the leg and possibly avoid amputation.
AngersAges 18 years+ - NCT06277362Recruiting
New Leg-Saving Treatment for Critical Limb Ischemia
This study tests a new way to restore blood flow to the leg in people who have wounds or dead tissue on their foot and have run out of other treatment options. It's for those who have already tried angioplasty twice without success or have severely hardened small arteries.
Ancona, AnconaAges 18 years+ - NCT06296576Recruiting
Testing a new way to predict critical limb ischemia
This trial uses a Doppler ultrasound to measure blood flow speed in your leg arteries to see if it can better predict a severe form of peripheral artery disease called critical limb ischemia. You may qualify if you have known artery disease in your leg and are already scheduled for a toe blood pressure test.
CholetAges 18 years+ - NCT06318767Recruiting
Foot Blood Flow Measurements to Predict Limb and Heart Events
This study measures how blood flows through your foot using ultrasound to see if it can predict serious problems with your leg or heart in people with severe circulation problems. The goal is to find a simple test that helps doctors decide the best treatment for you.
AmiensAges 18 years+ - NCT06482892RecruitingPhase 2
Testing a new drug for severe leg artery disease
This trial tests an experimental drug for people with critical limb ischemia, a serious condition where not enough blood reaches the legs. It aims to see if the drug can help with pain or healing of leg ulcers without the need for surgery.
Suzhou, JiangsuAges 18 years+ - NCT06544135Recruiting
Thermal camera study for blood flow in PAD with tissue loss
This study uses a special camera that detects heat to see blood flow in your leg before and after a procedure to open blocked arteries.
Beachwood, OhioAges 18–99 - NCT03529019RecruitingEarly Phase 1
Nutrition study for poor blood flow to a limb
This early-phase study looks at how nutrition affects people who have very poor blood flow to a limb (critical limb ischemia). It’s exploring whether nutrition changes health outcomes and safety for this condition.
Boston, MassachusettsAges 18–99 - NCT07023965Enrolling by invitation
Long-term follow-up study for gene therapy in critical limb ischemia
This study follows up with people who previously took part in a clinical trial testing an experimental gene therapy for critical limb ischemia (severe leg pain or sores due to blocked arteries). It aims to see how well the treatment works over time. If you were in that earlier trial and received at least one dose, joining this follow-up could help researchers learn more about the therapy's lasting effects.
Beijing, Beijing MunicipalityAges 20–85 - NCT05145478Recruiting
Real-world outcomes after Shockwave treatment for blocked leg artery
This study follows what happens in real life after using Shockwave’s device (intravascular lithotripsy) to treat a hard, calcified blockage in the common femoral artery, then completing standard treatment. It may help doctors understand which patients benefit and what results to expect.
New Haven, ConnecticutAges 18 years+ - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT04027244Recruiting
Studying care plans for severe leg blood flow problems
This study looks at how best to manage severe leg ischaemia, a condition where blood flow to the leg is dangerously reduced. It mainly involves patients who are planning an intervention, and some participants may also do special heart imaging tests.
Leicester, LeicestershireAges 18–110 - NCT04054609Recruiting
FAZA PET/MRI scan before and after leg revascularization
This study uses a special combined scan (PET/MRI) to look at blood flow and tissue changes in people with severely reduced blood supply to the legs. The scan is done before and after a procedure to reopen blocked blood vessels, to understand how well treatment works.
Toronto, OntarioAges 18 years+ - NCT04433572RecruitingPhase 3
Temsirolimus treatment to improve below-knee artery procedures
This trial studies whether delivering a medicine called temsirolimus directly into the artery during a below-knee revascularization procedure can improve blood flow and outcomes. It may help people with severe leg artery disease who have symptoms like pain while walking or threatened limb tissue loss.
Houma, LouisianaAges 18 years+ - NCT05971394Recruiting
Sirolimus stent for severe blocked leg arteries
This trial tests a special stent-like device placed in blocked arteries below the knee to improve blood flow in people with critical limb ischemia. If you meet the artery and health requirements, the goal is to reduce artery re-blocking and help prevent worsening leg problems over 12 months.
FlorenceAges 18–85 - NCT06204237RecruitingEarly Phase 1
PET imaging safety study for leg artery disease patients and healthy volunteers
This study tests whether a new radioactive tracer called APAC is safe and can be seen in PET/CT scans. It is for people with blocked leg arteries (PAOD/CLI) and for healthy volunteers. The goal is to see where the tracer goes in the body and how the body tolerates it.
GroningenAges 40–85 - NCT06434194Recruiting
Stent study for severe leg pain or wounds
This trial tests a new stent to improve blood flow in blocked leg arteries causing severe pain or tissue loss. It may help if you have a long blockage in the upper leg but not below the knee.
New York, New YorkAges 19 years+
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Critical Limb Ischemia trials by city
Studies with a site in or near these metro areas.
Common questions
- Are there clinical trials for critical limb ischemia?
- Yes. Clin2 currently lists 29 recruiting critical limb ischemia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a critical limb ischemia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a critical limb ischemia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.