Clinical trials
Liposomal Bupivacaine clinical trials
Below are recruiting liposomal bupivacaine clinical trials, each written for real people, not researchers. We’re tracking 48 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT07049094RecruitingPhase 4
Scalp nerve block for pain after brain surgery
This trial tests if a long-lasting numbing medicine (bupivacaine liposomes) injected into scalp nerves can reduce pain after brain surgery. It may help you need less pain medicine and feel better after your operation.
Hangzhou, ZhejiangAges 18 years+ - NCT06165991RecruitingPhase 4
Comparing two types of numbing medicine for lung surgery pain
This trial compares two forms of a numbing medicine (bupivacaine) injected near the spine to reduce pain after lung surgery. It aims to find which works better for controlling pain after a lobectomy (removal of a lung lobe).
Jinan, ShandongAges 18 years+ - NCT06252662RecruitingPhase 4
Comparing two numbing medicines for mastectomy nerve blocks
This study compares two types of numbing medicine given through a nerve block before a mastectomy. One is a long-acting version (liposomal bupivacaine) and the other is a standard numbing medicine combined with a sedative (bupivacaine with dexmedetomidine). The goal is to see which provides better pain relief after surgery.
Portsmouth, VirginiaAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07134660Recruiting
Comparing two numbing medicines for lung surgery pain
This study compares two types of numbing medicine (liposomal vs. hydrochloride bupivacaine) injected near the ribs during lung surgery. The goal is to see which one provides better pain relief after the operation.
ShanghaiAges 18–80 - NCT06411795RecruitingPhase 2
Comparing two pain relief methods after Whipple surgery
This study compares two ways to manage pain after Whipple surgery: a long-lasting numbing injection near the belly muscles (rectus sheath block) versus an epidural (a tube placed in your back). The goal is to see which method provides better pain relief and recovery.
Minneapolis, MinnesotaAges 18 years+ - NCT03906617RecruitingPhase 4
Pain-relief shots for lung surgery: three drug options compared
This study compares different pain-relief medications given during lung surgery to see which one controls pain better. It may help people have less post-surgery pain after robotic wedge resection or lobectomy.
Camden, New JerseyAges 18–90 - NCT06344091RecruitingPhase 4
Long-lasting pain relief for kids having bone surgery
This study tests an injection that numbs the surgery area for a longer time after bone surgery in children. It may help reduce pain and the need for other pain medicines during recovery.
Guangzhou, GuangdongAges 6–17 - NCT07081373Recruiting
Repeat dose of liposomal bupivacaine for pain after anal fistula surgery
This trial tests if a repeat dose of liposomal bupivacaine (a long-acting numbing medicine) helps reduce pain after surgery for anal fistula. It may be a good option if you are having this surgery and want better pain control.
Guangzhou, GuangdongAges 18–60 - NCT06972680Enrolling by invitation
Finding the best dose for a shoulder block before surgery
This trial tests different volumes of a long-lasting numbing medicine (Exparel) injected around the shoulder nerves before arthroscopic surgery. The goal is to find the dose that provides the best pain relief.
Jiaxing, ZhejiangAges 18 years+ - NCT07651722Recruiting
Pain control and gut recovery after abdominal surgery
This trial tests a combination of two pain-management approaches—a long-acting numbing medicine injected near nerves and a self-administered opioid—to see if they help your gut function better and control pain after bowel or colon surgery.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT06959147RecruitingPhase 4
Study for nerve pain after shingles using radiofrequency and a numbing shot
This trial tests a two-step procedure for treating nerve pain after shingles (called postherpetic neuralgia). First, a special type of radiofrequency treatment is applied to block the pain signals. Then, a long-lasting numbing medicine is injected under the skin to help keep the pain away. It is for people aged 40 to 85 who have not gotten enough relief from standard medicines.
Zunyi, GuizhouAges 40–85 - NCT05224089RecruitingPhase 4
Numbing shot comparison for pain control in laparoscopic colon surgery
This study compares two types of numbing injections (a longer-acting option versus standard numbing) placed near nerves to help control pain during laparoscopic colon surgery. It looks to see which method works better and is safe for patients having planned surgery.
Hartford, ConnecticutAges 18 years+ - NCT05972018RecruitingPhase 4
Liposomal numbing medicine for belly incisions in vascular surgery
This study compares two numbing options for pain control after open belly (mid-abdominal) vascular surgery: a longer-lasting numbing drug in the belly muscle layer versus a different numbing drug and catheter. It aims to see which approach better reduces postoperative pain and opioid use, and may help improve recovery.
Hartford, ConnecticutAges 18–80 - NCT06077422Enrolling by invitationPhase 2/Phase 3
Comparing two pain blocks for heart surgery recovery
This trial compares two types of pain blocks (Exparel vs. Marcaine) given during heart surgery to see which one provides better pain relief. If you are scheduled for a heart surgery through a small or full chest incision, you may be able to join.
New Brunswick, New JerseyAges 18 years+ - NCT03737292RecruitingPhase 4
Numbing medicine for chest surgery pain after small lung operations
This trial tests whether a long-lasting numbing shot (liposomal bupivacaine) works better than a regular numbing shot (plain bupivacaine) for pain after minimally invasive chest surgery. It may help you have less post-surgery pain and potentially use less pain medication.
Hershey, PennsylvaniaAges 18 years+ - NCT07349810RecruitingPhase 4
Post-surgery pain pump study
This trial tests a pain pump after specific shoulder or knee surgeries to see how well it controls pain. It may help you recover more comfortably after surgery.
Somerset, New JerseyAges 18 years+ - NCT06810375RecruitingPhase 3
Nerve Blocks for Pain After Video-Assisted Lung Surgery
This trial tests two different numbing shots (nerve blocks) to see which one works better for pain after video-assisted lung surgery. One block is placed near the spine, and the other is between the ribs. The goal is to find the best way to keep you comfortable after surgery.
Washington D.C., District of ColumbiaAges 18–90 - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT03420638RecruitingPhase 4
Pain relief after tonsillectomy
This study tests a long-lasting numbing medicine (bupivacaine) injected during tonsillectomy to see if it helps reduce pain after surgery. It may offer better pain control than standard care.
Ann Arbor, MichiganAges 18 years+ - NCT07348016Recruiting
Platelet-rich plasma and steroid injection for shoulder surgery
This trial tests if adding a combination of platelet-rich plasma (a concentrate from your own blood that may help healing) and a steroid (to reduce inflammation) during arthroscopic surgery improves recovery for people with a torn rotator cuff and a stiff, stuck shoulder.
Nanchang, JiangxiAges 18–70 - NCT06452147Recruiting
Anesthesia types for preventing confusion after hip surgery in older adults
This study looks at different ways to give anesthesia during hip surgery to help older patients think and remember better afterward. It may help prevent confusion or memory problems that sometimes happen after surgery.
Dongyang, ZhejiangAges 65 years+
Hear when a new Liposomal Bupivacaine trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for liposomal bupivacaine?
- Yes. Clin2 currently lists 48 recruiting liposomal bupivacaine studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a liposomal bupivacaine trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a liposomal bupivacaine trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.