Clinical trials
Long COVID Fatigue clinical trials
Below are recruiting long covid fatigue clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07726082Recruiting
A group program to help with long-term fatigue
This study tests a new way to help people with long-term fatigue that gets in the way of daily life. It uses a group program that focuses on making small, helpful choices to feel better.
BaselAges 18–65 - NCT06980636RecruitingPhase 4
Shengmai liquid for long covid fatigue trial
This trial tests if a traditional Chinese medicine, Shengmai Liquid, can help reduce fatigue in people with long COVID. It is for adults aged 18 to 75 who feel tired for a long time after a COVID infection.
Beijing, ChinaAges 18–75 - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT05931497Recruiting
Sauna heat treatment for long COVID fatigue
This trial tests whether regular sauna sessions using infrared heat can reduce fatigue from long COVID. You may be eligible if you have ongoing fatigue after a confirmed or strongly suspected COVID infection and can safely spend time lying in a sauna.
Boston, MassachusettsAges 18–65 - NCT06156176Recruiting
Exercise for COVID-19 fatigue: a feasibility study
This study tests whether a personalized exercise program can help reduce fatigue after a COVID-19 infection. You'll work with a coach over video calls to see if gentle activity can improve your energy levels.
London, OntarioAges 18 years+ - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT06631287RecruitingPhase 3
Testing baricitinib for persistent long COVID symptoms
This trial tests whether the anti-inflammatory drug baricitinib can improve persistent long COVID symptoms like brain fog, fatigue, and shortness of breath. You may qualify if you had COVID-19 at least 6 months ago and still have bothersome symptoms that affect your daily life.
Tucson, ArizonaAges 18 years+ - NCT06721949RecruitingPhase 2/Phase 3
Taurine for long COVID symptoms
This trial tests if taking taurine, a natural amino acid supplement, can help reduce lingering symptoms of COVID-19 that last for months. If you have had COVID-19 and still have symptoms like fatigue or brain fog for at least 2 months after 3 months from your infection, this study might be for you.
Edmonton, AlbertaAges 18 years+ - NCT06864156Recruiting
Molecules and vitamin levels in long COVID with brain fog
This study looks at certain molecules (called microRNAs) and vitamin B12 levels in people who have ongoing brain-related symptoms like depression, anxiety, or fatigue after a COVID-19 infection. It may help understand why some people have long-lasting symptoms and could lead to better treatments.
Mexico City, Mexico CityAges 18–65 - NCT06871293Recruiting
Long Covid recovery: rehab with coaching
This study tests a program of rehab exercises and memory/thinking activities, along with coaching messages, to help people with Long Covid feel better and function in daily life. You may qualify if you had Covid, have high blood pressure or diabetes, and still have symptoms like fatigue or trouble thinking for at least 4 weeks.
Bogotá, Bogotá DCAges 18–80 - NCT06883513Recruiting
Osteopathic therapy for long COVID symptoms
This trial tests if gentle hands-on treatment (osteopathic manipulative therapy) can help relieve long-lasting COVID symptoms like fatigue, brain fog, and body pain.
Louisville, KentuckyAges 18 years+ - NCT06928272RecruitingPhase 3
Long COVID drug study for adults 18 to 65
This study tests whether a commonly used drug (repurposed) can help improve Long COVID symptoms like fatigue, breathing problems, or brain fog. It is for adults 18 to 65 who had COVID-19 in the past 4 years and still have symptoms after 3 months.
San Diego, CaliforniaAges 18–65 - NCT06960928RecruitingPhase 3
Low dose sirolimus for long COVID
This trial tests if a low dose of sirolimus, a medicine that calms the immune system, can help people with long COVID. If you have had long COVID symptoms for at least 6 months, like severe fatigue, brain fog, or chest pain, you may be able to join.
New York, New YorkAges 18 years+ - NCT07021794RecruitingPhase 2
Antibody treatment for Long COVID symptoms
This study tests whether a lab-made antibody (sipavibart) can reduce Long COVID symptoms. It is for people who developed Long COVID after a confirmed COVID infection and still have moderate to severe fatigue and other ME/CFS-like symptoms.
Fort Lauderdale, FloridaAges 18–70 - NCT07123727RecruitingPhase 2
Testing Anktiva for long COVID symptoms
This study tests if the drug Anktiva can help people with long COVID. To join, you must have had at least one confirmed COVID-19 infection and now have lasting symptoms that started or got worse after that infection.
El Segundo, CaliforniaAges 18–70 - NCT07278206Recruiting
Brain stimulation for long COVID fatigue and brain fog
This trial tests whether a non-invasive brain treatment called rTMS (repetitive transcranial magnetic stimulation) can help with the severe fatigue and brain fog that often come with long COVID. You would need to be able to come to the hospital for multiple treatment sessions.
AmsterdamAges 18 years+ - NCT07285707Recruiting
Acupuncture and herbs for long COVID
This small study tests whether acupuncture and Chinese herbal medicine can help relieve common long COVID symptoms like fatigue, cough, brain fog, and pain. It might be a good fit if you are struggling with ongoing symptoms after COVID and are looking for a treatment approach that isn't just more medication.
Whittier, CaliforniaAges 18 years+ - NCT07316127RecruitingPhase 2
Blood filtering for autoimmune long COVID
This trial tests if filtering certain antibodies from the blood can help people with long COVID who experience post-exertional malaise (PEM) and reduced function. It aims to see if this treatment reduces symptoms and improves daily life.
AmsterdamAges 18–65 - NCT07627815RecruitingPhase 2
Safety and Efficacy of PNMR for Long COVID
This study tests whether PNMR (a supplement product) can safely reduce symptoms of long COVID—the lingering fatigue, brain fog, and other problems that some people experience months after COVID infection. You'll take the study product, follow diet and exercise guidelines, and complete questionnaires and a walking test.
Brampton, OntarioAges 19 years+ - NCT07661862Recruiting
Managing heart and lung symptoms after COVID-19
This trial tests a program to help people with ongoing fatigue, shortness of breath, or chest pain after COVID-19. It uses a personalized plan to improve your daily function and heart health.
Hobart, TasmaniaAges 40 years+ - NCT06560554Enrolling by invitation
Fermented diet for long COVID microbiome health
This study tests whether eating fermented foods (like yogurt, kimchi, or sauerkraut) can improve gut health and ease symptoms in people with long COVID. You'll log your food on your phone and follow a fermented diet for a period of time.
Rochester, MinnesotaAges 18 years+ - NCT06511063RecruitingPhase 2
Antiviral trial for treating long covid symptoms
This study tests whether antiviral drugs (Truvada and Selzentry) can help people with long COVID. You may qualify if you have had long COVID symptoms for at least 6 months, including fatigue and post-exertional malaise.
New York, New YorkAges 18 years+ - NCT07108036RecruitingPhase 2
Testing Anktiva for Long COVID Symptoms
This trial tests a medicine called Anktiva to see if it can help people with Long COVID. It's for adults who had a confirmed COVID-19 infection and now have lasting symptoms like fatigue, brain fog, or trouble breathing.
San Francisco, CaliforniaAges 18–70 - NCT06528171Recruiting
Long COVID immunity and imaging study
This trial studies people who had COVID-19 to understand why some develop long-term symptoms while others recover fully. It aims to find links between the immune system and brain changes using imaging.
NiceAges 18 years+
Hear when a new Long COVID Fatigue trial opens
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Common questions
- Are there clinical trials for long covid fatigue?
- Yes. Clin2 currently lists 36 recruiting long covid fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a long covid fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a long covid fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.