Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07075068Recruiting
How smoking affects leg movement and coordination
This study tests how cigarette addiction changes the speed and coordination of your legs. If you are a smoker or a non-smoker, researchers will compare your movement to see if smoking makes a difference.
Istanbul, ÜsküdarAges 18–25 - NCT06901700Recruiting
Leg strength training at home for older adults
This study tests if doing leg strengthening exercises at home can improve muscle strength, balance, and daily function in older adults. It may help you stay steady on your feet and move more easily.
TaipeiAges 65–80 - NCT06774547Recruiting
Early jumping exercises for leg tendon pain
This study tests whether adding jumping exercises early helps people with long-lasting leg tendon pain recover faster.
AalborgAges 18–50 - NCT05644704Recruiting
Sports injury prevention training for baseball pitchers
This study tests an intelligent training system designed to help prevent injuries in healthy baseball pitchers. It’s for adults who are currently pitching and don’t have certain past injuries or medical conditions that could affect movement or nerves.
TaipeiAges 18–55 - NCT05780502Recruiting
Orthotic and rehab program for lower-limb musculoskeletal problems
This study tests an integrated brace (an exoskeletal orthosis) plus a rehabilitation plan for problems in the legs/lower limbs. It may help improve how you move and function while using a custom brace.
Charlotte, North CarolinaAges 18 years+ - NCT05739149Recruiting
Ultrasound checks how chronic foot ulcers heal
This study tests a special ultrasound scan to see how chronic diabetic or venous foot ulcers are healing. The goal is to use the scan to better track wound improvement and guide care.
Rochester, MinnesotaAges 18 years+ - NCT03135847Enrolling by invitation
Using feedback to improve prosthetic movement in amputees
This study tests whether movement “feedback” can help adults with arm or leg amputations control a prosthetic better. It may be most helpful if you can comfortably wear a prosthetic socket and can understand and consent to the study.
Ages 18–75 - NCT06396247RecruitingPhase 2/Phase 3
Daily leg exercises to improve walking
This study tests a simple daily leg-strengthening routine to see if it helps people who have trouble walking short distances. You'll do easy resistance exercises at home, which might make it easier to walk and move around.
Hershey, PennsylvaniaAges 65 years+ - NCT07613333Recruiting
Exercise Program for New Mothers
This study tests an exercise program designed for women who have given birth within the past 2 years. Researchers want to learn how exercise affects energy levels and overall health after pregnancy.
Waukesha, WisconsinAges 18 years+ - NCT07686809Recruiting
Leg therapy for children with one-sided weakness
This study tests a new leg exercise program to help children with hemiplegia walk better. The therapy may improve balance and movement in the affected leg.
CairoAges 6–8 - NCT06941467RecruitingPhase 1
Timolol eye drop solution for healing skin surgery wounds
This study tests whether applying timolol (a beta-blocker eye drop) to a wound after Mohs surgery can help it heal faster. If you are having Mohs surgery for skin cancer and have a wound between half an inch and 4 inches, you may be able to join.
New York, New YorkAges 18 years+ - NCT06996028Recruiting
Lift and pedals for balance and movement in children with CP
This study tests if doing lifting and pedaling exercises helps children with cerebral palsy improve their balance and ability to move around. It may be a good fit if your child can walk without much help and follow simple instructions.
Lahore, Punjab ProvinceAges 6–12 - NCT06710119Recruiting
Custom Brace for Foot and Ankle Injuries
This study tests whether a custom carbon fiber brace can help people with foot or ankle injuries walk with less pain and better balance. If you have an injury below your knee and need a special brace, this trial may be a good fit.
Iowa City, IowaAges 18–65 - NCT05929508Recruiting
Rebuilding leg strength after above-knee amputation
This study tests a new approach to improve walking ability and leg function after an above-knee (transfemoral) amputation. It may help by targeting muscle loss and supporting safer, stronger mobility over time.
Chicago, IllinoisAges 18 years+ - NCT06089057Enrolling by invitation
Social exercise program for aging with kidney disease
This study tests a program to help people with chronic kidney disease who are starting to feel frail (weak or slow). It uses social activities and gentle exercise to improve well-being and strength.
Nashville, TennesseeAges Any age - NCT07735949Recruiting
Daily footwear and leg health in hemophilia knee replacement
This study looks at how the shoes you wear every day affect your leg health and movement. It involves adults with hemophilia who are about to have their first total knee replacement and are willing to participate in a pre-surgery exercise program.
Istanbul, IstanbulAges 18–35 - NCT06156904Recruiting
Study of b.Bone bone graft for defects in arms, legs, pelvis
This trial is following patients who receive a bone graft using a product called b.Bone to treat bone defects in the arms, legs, or pelvis. Researchers will collect information during your regular follow-up visits to see how well the bone heals.
BerlinAges 18 years+ - NCT07220226Recruiting
Fontan circulation and venous compression study
This trial looks at how blood flow works in people with Fontan circulation, who have a unique heart surgery. It aims to understand vein compression and may help guide future care.
Dallas, TexasAges 18–45 - NCT07724483Recruiting
Ultrasound Study of Leg Muscles in Lipedema
This study uses an ultrasound to check the leg muscles of people with lipedema. It also looks at how your weight is distributed when you stand. The goal is to learn more about lipedema and how it affects your legs and walking.
Istanbul, PendikAges 18–65 - NCT05243966Recruiting
Registry for soft tissue repair using a special matrix
This study is a registry that collects information from people who had soft tissue repair using a specific matrix and/or morcell material. It may help researchers understand how this approach performs in real-world care and patient outcomes over time.
Phoenix, ArizonaAges 18 years+ - NCT03175718Recruiting
Pre-surgery radiation to reduce complications after leg sarcoma surgery
This study looks at whether giving radiation before surgery can lower wound healing problems and improve outcomes after operating on a leg soft-tissue sarcoma. It focuses on patients whose surgeons can close the wound directly after surgery and who can return for follow-up visits.
Ottawa, OntarioAges 18 years+ - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT04063592Recruiting
Surgery plan for pain or skin problems in a healed leg stump
This study looks at a surgical approach for people who already had an above-knee or below-knee amputation and now have ongoing pain or skin/stump problems that haven’t improved. It aims to improve comfort and how well the stump area heals, assuming you’re healthy enough for surgery under standard anesthesia.
Bethesda, MarylandAges 18–65 - NCT04640584Recruiting
C-Brace care registry to track brace comfort
This registry follows people who have been assessed and fitted for a C-Brace. It helps the study team understand how well the brace process works and collect your feedback to improve care.
Harrison, ArkansasAges Any age
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Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 122 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.