Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06156813Recruiting
Turkish lower limb movement log for stroke patients
This study aims to adapt a questionnaire that measures how well stroke survivors can use their legs in daily life. It may help doctors better understand your recovery and guide your rehabilitation.
GaziantepAges 18–80 - NCT06494618Recruiting
Botulinum toxin plus shockwave for leg spasticity in cerebral palsy
This study tests if combining botulinum toxin injections with radial extracorporeal shockwave therapy (RESWT) works better than injection alone for reducing leg spasticity in children with cerebral palsy. If your child has spasticity in leg muscles and is already receiving botulinum toxin, they may benefit from this additional therapy.
Istanbul, KadikoyAges 2–18 - NCT07319403Recruiting
Hip or ankle exercises for ankle instability in athletes
This study compares two exercise programs—one focusing on the hip, the other on the ankle—to see which is better for improving leg function in athletes with chronic ankle instability. The goal is to help athletes regain strength and confidence in their ankle.
Ankara, ÇankayaAges 18–40 - NCT07303582RecruitingPhase 4
Freezing nerves to ease pain from muscle tightness
This study tests if freezing specific nerves (cryoneurolysis) can reduce pain caused by muscle tightness (spasticity) after a brain or spinal cord injury, or from multiple sclerosis. It is for people who already get Botox injections for this pain.
OxfordAges 18 years+ - NCT06878482RecruitingPhase 4
Botulinum toxin injection for severe leg artery disease
This trial tests whether a single injection of botulinum toxin (a muscle-relaxing substance) into the leg can improve blood flow and help heal wounds in people with severe blocked leg arteries who cannot have standard procedures like angioplasty.
Yongin-si, Gyeonggi-doAges 20 years+ - NCT07266753RecruitingPhase 4
Comparing oral antibiotics for leg and foot bone infections
This trial compares two common types of oral antibiotics to see which works better for bone infections below the knee. If you have a bone infection that needs at least 28 more days of treatment and you can take pills, this study may help find the best option for you.
Ottawa, OntarioAges 18 years+ - NCT07241572Recruiting
Heart injury risk during below-knee surgery
This trial checks for heart muscle injury during surgery on the lower leg (below the knee). It helps doctors understand how to better protect patients having this type of operation.
AnkaraAges 18 years+ - NCT07219095Recruiting
Dance Mental Health App for Injured Teens
This trial tests a mental health app (SuperBetter) for teens who dance and have a leg injury. It aims to help them cope and stay positive while recovering.
San Diego, CaliforniaAges 13–18 - NCT07220226Recruiting
Fontan circulation and venous compression study
This trial looks at how blood flow works in people with Fontan circulation, who have a unique heart surgery. It aims to understand vein compression and may help guide future care.
Dallas, TexasAges 18–45 - NCT07202780Enrolling by invitation
MS and Muscle Strength in Breathing and Legs
This study looks at how MS affects the strength of your breathing muscles and leg muscles. If you join, you will have tests to measure your muscle strength, walking ability, and fatigue. This may help doctors understand how to better treat MS-related weakness.
Gaziantep, şehitkamilAges 18–50 - NCT04640584Recruiting
C-Brace care registry to track brace comfort
This registry follows people who have been assessed and fitted for a C-Brace. It helps the study team understand how well the brace process works and collect your feedback to improve care.
Harrison, ArkansasAges Any age - NCT06217276Recruiting
Breathing muscle fatigue and leg oxygen in COPD
This study looks at how breathing muscle tiredness relates to oxygen levels in leg muscles for people with moderate-to-severe COPD. It may help patients understand their condition better.
Istanbul, ZeytinburnuAges 18–75 - NCT07142408RecruitingPhase 3
Bacteria reduction before skin cancer surgery on legs
This trial tests if reducing bacteria on your skin before skin cancer surgery on the leg can lower the risk of infection, especially for wounds left open to heal naturally.
Marlton, New JerseyAges 18 years+ - NCT07075068Recruiting
How smoking affects leg movement and coordination
This study tests how cigarette addiction changes the speed and coordination of your legs. If you are a smoker or a non-smoker, researchers will compare your movement to see if smoking makes a difference.
Istanbul, ÜsküdarAges 18–25 - NCT07073235Recruiting
Brain stimulation to help leg movement after chronic stroke
This trial is testing if a non-invasive brain stimulation technique, called iTBS, can improve leg movement in people who have had a stroke more than six months ago and still have some weakness on one side.
StockholmAges 18 years+ - NCT06996028Recruiting
Lift and pedals for balance and movement in children with CP
This study tests if doing lifting and pedaling exercises helps children with cerebral palsy improve their balance and ability to move around. It may be a good fit if your child can walk without much help and follow simple instructions.
Lahore, Punjab ProvinceAges 6–12 - NCT07012642RecruitingEarly Phase 1
GLP-1 drugs for arm or leg swelling (lymphedema)
This trial tests if a class of diabetes drugs (GLP-1 receptor agonists) can reduce swelling in one arm or leg caused by lymphedema. It may help people who have not found relief from other treatments.
Red Bank, New JerseyAges 18 years+ - NCT06941467RecruitingPhase 1
Timolol eye drop solution for healing skin surgery wounds
This study tests whether applying timolol (a beta-blocker eye drop) to a wound after Mohs surgery can help it heal faster. If you are having Mohs surgery for skin cancer and have a wound between half an inch and 4 inches, you may be able to join.
New York, New YorkAges 18 years+ - NCT06901700Recruiting
Leg strength training at home for older adults
This study tests if doing leg strengthening exercises at home can improve muscle strength, balance, and daily function in older adults. It may help you stay steady on your feet and move more easily.
TaipeiAges 65–80 - NCT06778005Recruiting
Ultrasound of leg nerves in type 2 diabetes with nerve damage
This study uses ultrasound (an imaging test) to measure the nerves in the legs of people with type 2 diabetes who have nerve damage. It helps doctors learn more about how diabetes affects nerves.
Istanbul, ÜsküdarAges 18–65 - NCT06774547Recruiting
Early jumping exercises for leg tendon pain
This study tests whether adding jumping exercises early helps people with long-lasting leg tendon pain recover faster.
AalborgAges 18–50 - NCT06724861Recruiting
Sensory rehabilitation for chemo-related nerve pain
This trial is testing a sensory rehabilitation program for people who have ongoing nerve pain or numbness in their hands or feet after chemotherapy. It aims to help improve sensation and movement.
TzrifinAges 18 years+ - NCT06710119Recruiting
Custom Brace for Foot and Ankle Injuries
This study tests whether a custom carbon fiber brace can help people with foot or ankle injuries walk with less pain and better balance. If you have an injury below your knee and need a special brace, this trial may be a good fit.
Iowa City, IowaAges 18–65 - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45
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Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 122 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.