Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04877444RecruitingEarly Phase 1
Exercise program to improve arm recovery after stroke
This early-stage trial tests a special exercise approach meant to “prime” the brain and improve arm movement after a stroke. You may be eligible if you’re 6+ months out from a one-sided stroke and can safely do an exercise test.
Charleston, South CarolinaAges 50–90 - NCT05132439RecruitingPhase 3
Metformin to improve walking in leg artery blockage
This Phase 3 study tests whether metformin can help people with intermittent claudication (leg pain when walking) walk farther. It compares how well metformin works on walking ability alongside standard (already recommended) heart and blood-vessel medicines.
Pittsburgh, PennsylvaniaAges 35–89 - NCT05381818Recruiting
Breathing muscle training before joint surgery
This trial tests whether strengthening breathing muscles before total joint surgery can lower the chance of lung complications after the operation. It may help people who already have breathing problems or a history of smoking.
Jacksonville, FloridaAges 18–100 - NCT05623111RecruitingPhase 2
Nerve-area Botox shots for diabetic foot nerve pain
This Phase 2 trial tests whether injecting incobotulinumtoxin-A near painful nerves can reduce nerve-type pain in the feet for people with diabetes. If you have lasting, fairly symmetrical pain in both feet, the injections may help calm the nerve pain signals.
Glostrup MunicipalityAges 18 years+ - NCT05779670Recruiting
Check if home exercises work after leg bone tumor surgery
This trial looks at whether a personalized home exercise plan helps people recover after surgery to rebuild a lower leg for a bone tumor. It may help by improving exercise adherence using support for at-home care during treatment.
BolognaAges 12–90 - NCT05845021Recruiting
Screening and referral for bone health after hip or knee surgery
This study looks at a simple plan for surgeons to identify people with low bone strength (osteoporosis) and refer them for bone health care after hip or knee replacement surgery. It may help you get evaluated and treated earlier if you have osteoporosis.
Columbia, MarylandAges 50 years+ - NCT05884944Recruiting
Osteopathic massage study for leg muscle in Parkinson’s disease
This trial studies whether osteopathic manipulative medicine (gentle hands-on treatment) can change how leg muscles work in people with Parkinson’s disease. It may help with leg pain, cramping, or walking problems caused by Parkinson’s.
Old Westbury, New YorkAges 18 years+ - NCT06059872Recruiting
Study of high-intensity interval training after stroke
This study tests whether a high-intensity interval training (HIIT) exercise program can help people with walking difficulties after a stroke. It looks for veterans who have had a stroke at least 6 months ago and walk slowly, to see if this type of exercise can improve their recovery.
Decatur, GeorgiaAges 18–89 - NCT06098157Recruiting
Non-healed broken bones in arm or leg after surgery
This is a registry study that collects information from people who have had surgery for a broken arm or leg bone that did not heal on its own. It helps doctors better understand why some bones don't heal and how to improve treatment.
Tübingen, Baden-WurttembergAges 18 years+ - NCT06105788Recruiting
Exercise and pain relief for knee arthritis
This study looks at how moving your arms and legs might help reduce pain for people with knee osteoarthritis. If you join, you will do some light exercise so researchers can see if it helps your knee feel better.
El Paso, TexasAges 45–90 - NCT06131658Recruiting
Functional training for iliotibial band syndrome in runners
This trial tests whether functional motor control exercises can reduce pain and improve flexibility and leg function in runners with IT band syndrome. It may help you run without pain on the outside of your knee.
Faisalābad, Punjab ProvinceAges 19–40 - NCT06156813Recruiting
Turkish lower limb movement log for stroke patients
This study aims to adapt a questionnaire that measures how well stroke survivors can use their legs in daily life. It may help doctors better understand your recovery and guide your rehabilitation.
GaziantepAges 18–80 - NCT06215248Recruiting
Heart function study in leg artery disease patients
This trial uses ultrasound to check how well the heart pumps in people with blocked leg arteries. It aims to find early signs of heart strain that standard tests might miss.
TartuAges 35–85 - NCT06217276Recruiting
Breathing muscle fatigue and leg oxygen in COPD
This study looks at how breathing muscle tiredness relates to oxygen levels in leg muscles for people with moderate-to-severe COPD. It may help patients understand their condition better.
Istanbul, ZeytinburnuAges 18–75 - NCT06223217Recruiting
New quality-of-life survey for leg artery disease patients
This study tests a new questionnaire (modified VascuQol) to measure how leg artery disease affects your daily life. It aims to create a better tool for doctors to track your symptoms and well-being.
Shanghai, Shanghai MunicipalityAges 18–90 - NCT06274697Recruiting
Testing a magnetic sensor for artery blood flow
This study tests a new magnetic sensor that measures blood flow in your arteries, comparing it to the standard method. It takes place in the heart-lung unit at Montpellier University Hospital, and aims to see if the sensor is accurate for people with or without leg artery disease.
MontpellierAges 18 years+ - NCT06343688Recruiting
How ankle braces affect motor skills in CP
This study tests how wearing special ankle braces (called DAFOs) right away affects movement and balance in children with spastic diplegic cerebral palsy. It aims to see if the braces make it easier to walk and stand.
BoluAges 4–15 - NCT06411197Recruiting
Walking and muscle pain in healthy adults
This study looks at how people walk and how muscles in the legs may feel sore. It is for healthy adults to understand normal movement patterns.
Aalborg, North DenmarkAges 18–45 - NCT06428032Recruiting
Habit training for children with bilateral cerebral palsy
This trial tests a therapy called HABIT-ILE to see if it helps children with bilateral cerebral palsy improve hand use and brain function. It may be a good fit if your child can follow instructions and has certain levels of hand and movement ability.
Santiago, Santiago MetropolitanAges 8–18 - NCT06494618Recruiting
Botulinum toxin plus shockwave for leg spasticity in cerebral palsy
This study tests if combining botulinum toxin injections with radial extracorporeal shockwave therapy (RESWT) works better than injection alone for reducing leg spasticity in children with cerebral palsy. If your child has spasticity in leg muscles and is already receiving botulinum toxin, they may benefit from this additional therapy.
Istanbul, KadikoyAges 2–18 - NCT06653855Recruiting
Cupping for leg stiffness and movement after stroke
This study tests if cupping therapy can reduce leg stiffness and improve movement in people recovering from a stroke. You must be getting rehab at a specific clinic in Joliet.
Joliet, IllinoisAges 30–80 - NCT06673823Recruiting
Mirror therapy for leg movement in children with CP
This study tests whether mirror therapy—where your child watches the reflection of their good leg moving—can help improve movement in their affected leg. It is designed for children with cerebral palsy who have mild to moderate leg stiffness.
Lahore, Punjab ProvinceAges 6–12 - NCT07685730Recruiting
Comparing blood pressure readings in arm vs leg during C-section
This study compares blood pressure measurements taken from the arm versus the leg during planned Cesarean sections using a special monitor. It aims to see which location gives more accurate readings for women having spinal anesthesia.
Columbus, OhioAges 18 years+ - NCT06778005Recruiting
Ultrasound of leg nerves in type 2 diabetes with nerve damage
This study uses ultrasound (an imaging test) to measure the nerves in the legs of people with type 2 diabetes who have nerve damage. It helps doctors learn more about how diabetes affects nerves.
Istanbul, ÜsküdarAges 18–65
Hear when a new Lower Extremity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 122 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.