Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 120 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07335341Recruiting
Liberant thrombectomy system case survey
This survey collects feedback from doctors who used the Liberant system to remove blood clots. The results help understand how well the device works in real-life procedures.
Washington D.C., District of ColumbiaAges 22 years+ - NCT06776887Recruiting
Virtual reality exercises for burn recovery on legs
This trial tests whether virtual reality exercises can help people with leg burns improve balance and reduce depression and anxiety. It is for people who had a large thermal burn on their lower body at least 3 months ago.
GizaAges 35–55 - NCT06293469Recruiting
Speeding up flap surgery for severe leg injuries
This trial tests whether performing flap surgery sooner after a severe leg injury below the knee leads to better outcomes. If you have an open fracture or dislocation that needs a flap, you may be able to join.
Sacramento, CaliforniaAges 18 years+ - NCT06770634Recruiting
Pain sensitivity and related factors in lipedema
This study looks at how pain sensitivity (central sensitization) affects people with lipedema. It aims to understand what factors are linked to increased pain in this condition, which might help improve care.
Istanbul, ÜsküdarAges 18–65 - NCT07314450Recruiting
Pain and sedation for fracture and dislocation treatment in the ER
This study tests how well pain and sedation medicines work in the emergency department when treating adults with certain broken bones or dislocated joints that need to be set or casted. It aims to see which approach is safest and most comfortable for patients.
Holbæk, Region SjællandAges 18 years+ - NCT07653165Enrolling by invitation
Wound therapy for chronic leg wounds
This trial is testing a new way to clean and treat chronic leg wounds using a special wound therapy and gentle suction. It may help wounds that have not healed for a long time.
Coconut Creek, FloridaAges Any age - NCT07697482Recruiting
Breathing and relaxation training for leg swelling
This study tests whether combining breathing and relaxation exercises with standard care can help reduce leg swelling and improve how well you walk. It is for women who have had lymphedema in their legs for at least 3 months.
AdanaAges 18–65 - NCT04912323Recruiting
Drug dissolving stent for blocked below-knee arteries
This trial studies a drug-eluting dissolving scaffold placed in blocked arteries below the knee to improve blood flow. It may help people whose leg circulation problems are severe enough to limit walking or threaten the limb, but only if their blockages fit specific imaging and procedure requirements.
GrazAges 18–90 - NCT06753812Enrolling by invitation
Lower limb therapy for children with unilateral cerebral palsy
This trial tests a therapy called constraint-induced movement therapy (CIMT) for the legs in children with unilateral cerebral palsy. It aims to improve leg function by encouraging use of the affected leg through structured exercises and activities.
BoluAges 5–15 - NCT06579326Recruiting
Using light and sound to check leg artery health
This trial uses a special imaging test (photoacoustic tomography) to see how well blood flows in the legs. It is for people with or without peripheral artery disease (PAD) to help improve diagnosis.
Guangzhou, GuangdongAges 18 years+ - NCT04861506Recruiting
Clot-removal treatment for blocked blood flow in the leg
This trial tests how safe and effective a clot-removal procedure done through the blood vessels is for people with acute or subacute blocked blood flow in the lower leg. It may help by improving circulation while carefully tracking risks and results.
Hangzhou, ZhejiangAges 18 years+ - NCT05740605Recruiting
Testing an at-home therapy program for bilateral cerebral palsy
This trial tests an at-home intervention (called HABIT-ILE) for children with bilateral cerebral palsy, delivered over two weeks. It aims to see whether home-based therapy and assessments help children function better and whether families can follow the program.
BrusselsAges 5–18 - NCT05727111Recruiting
Home therapy program for people with long-term stroke
This trial tests a structured therapy program done at home to help with movement after chronic stroke. It may help if you have lasting arm/hand problems and can follow simple instructions with a caregiver’s daily support.
BrusselsAges 18–100 - NCT06496035Recruiting
Blood flow training for leg fracture recovery
This study tests whether a special exercise method called blood flow restriction training helps people heal faster after a broken shinbone (tibia). It might improve strength and recovery during physical therapy.
Denver, ColoradoAges 18–100 - NCT07525895Enrolling by invitation
Nerve Stretching for Lower Leg Pain Relief
This study tests whether gentle stretching exercises targeting the sciatic nerve (a major nerve in your leg) can help reduce leg pain and improve how your body perceives pain. Researchers will compare this treatment to standard care to see if it works.
Istanbul, AtaşehirAges 18–30 - NCT07374835Enrolling by invitation
Weight-based treatment for leg swelling after gynecologic cancer surgery
This study tests a treatment plan based on your body mass index (BMI) to help reduce leg swelling (lymphedema) that started within 2 years after gynecologic cancer surgery. It aims to find a more personalized way to manage this condition.
Wuhan, HubeiAges 18–75 - NCT07217626RecruitingPhase 4
Nerve blocks before leg fracture surgery in older adults
This trial tests whether giving a nerve block (medicine to numb the leg) before surgery helps older adults recover better from a broken leg bone. If you are 50 or older and need surgery for a specific type of leg fracture, you may be eligible.
Baltimore, MarylandAges 50 years+ - NCT07603076Recruiting
Vein Problems and Symptoms in Lipedema
This study looks at how vein function relates to lipedema (a condition causing painful fat buildup in legs). Researchers will use ultrasound to check your veins and ask about your symptoms to better understand how the two conditions connect.
Istanbul, UskudarAges 18–65 - NCT07073040Recruiting
Cold plasma therapy for diabetic foot ulcers with blocked arteries
This trial tests whether adding cold atmospheric plasma (a gentle gas treatment) to a standard procedure that opens blocked leg arteries can help diabetic foot ulcers heal better and faster.
Anshan, LiaoningAges 18–80 - NCT07198061Recruiting
Cold Plasma for Diabetic Foot Ulcers After Leg Artery Treatment
This study tests whether adding cold atmospheric plasma treatment to standard care helps heal foot ulcers in people with diabetes who have recently had a procedure to open blocked leg arteries. The goal is to see if this approach is safe and more effective than current care alone.
Anshan, LiaoningAges 18–80 - NCT04934839Recruiting
Gait study comparing prosthetic walking types in adults
This study compares how people walk using an osseointegrated prosthesis (a prosthesis connected to the bone) versus a traditional socket prosthesis. It may help researchers understand which option works better for walking balance, comfort, and function.
Milan, MIAges 18 years+ - NCT07721792Recruiting
Study on advanced braces for leg injuries
This study tests a new type of leg brace for people who currently use an ankle-foot orthosis (AFO) to help with walking or daily activities after a lower leg injury. The goal is to see if the new brace works better and is more comfortable.
Tampa, FloridaAges 18–80 - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60
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Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 120 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.