Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 121 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT07604948Recruiting
Blood Flow Restriction Training for Basketball Recovery
This study tests whether briefly restricting blood flow to the legs (using an arm cuff on the thigh) can help male basketball players recover faster and improve leg strength after games. Researchers want to see if this technique, called ischemic preconditioning, reduces fatigue and speeds healing.
Guangzhou, GuangdongAges 18–25 - NCT06747117Recruiting
Removing blood clots in leg arteries with the Indigo system
This study tests a device that vacuums out blood clots from blocked leg arteries, potentially restoring blood flow without open surgery.
Scottsdale, ArizonaAges 18 years+ - NCT07253857Recruiting
Hand and arm therapy for children with cerebral palsy
This study tests a special hand and arm therapy for children with spastic cerebral palsy. The therapy also includes leg exercises to improve movement. It may help your child use their hands and arms better.
Lahore, Punjab ProvinceAges 6–12 - NCT06639802Recruiting
Therapy for balance and coordination in ataxic cerebral palsy
This trial tests a hand-arm and leg therapy program to improve balance and coordination in children with ataxic cerebral palsy. It may help your child move more steadily and confidently.
RawalpindiAges 6–15 - NCT07040683Recruiting
Vacuum dressing for skin grafts on lower leg
This study compares standard wound care to a special vacuum dressing (negative pressure therapy) after skin graft surgery on the lower leg for skin cancer. The goal is to see if the vacuum dressing helps the graft heal better.
MalmöAges 18 years+ - NCT06816836Recruiting
Measuring leg muscle mass to predict hospital stay after cancer surgery
This study uses ultrasound to measure leg muscle mass before surgery for gynecologic cancers, to see if it can predict how long you'll need to stay in the hospital after the operation.
Kolkata, West BengalAges 50–99 - NCT06839885Recruiting
Water Therapy for Swelling in One Leg
This trial tests whether water-based therapy (hydrotherapy) can help reduce swelling in one leg caused by lymphedema. It's for people who have already tried standard lymphedema treatment.
IstanbulAges 18–75 - NCT05225792Recruiting
Fast rehab program for leg injuries and amputations
This trial tests a rapid rehabilitation approach for people with certain leg injuries, including amputations and limb salvage, while you are already in standard rehab. It may help improve walking and balance after trauma by using a structured training program.
Rochester, MinnesotaAges 18 years+ - NCT07749625Recruiting
Robotic arm training for recovery after stroke or injury
This study tests whether a robotic arm trainer can help improve arm movement and function in people with conditions like stroke, spinal cord injury, or brain injury. It may help you regain strength and control in your arm.
DhakaAges 18–60 - NCT07749612Recruiting
Robotic arm trainer for stroke and brain injury recovery
This trial tests a robotic device that helps people move their arms and hands during rehabilitation after a stroke, brain injury, or spinal cord injury. The goal is to improve arm function and make daily tasks easier.
DhakaAges 18–60 - NCT07626645Recruiting
Shock wave therapy for leg swelling from lymphedema
This trial tests whether extracorporeal shock wave therapy—a non-invasive treatment that uses sound waves—can help reduce swelling in the legs caused by lymphedema. You would receive this treatment while continuing your current compression therapy.
Ankara, YenimahalleAges 18–80 - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT07863115Recruiting
Preventing blood clots after leg injury with a cast
This study looks at a simple checklist to see who is at risk for blood clots after a leg injury that requires a cast or brace. It also checks how well people follow blood-thinning medication to prevent these clots.
MonastirAges 18 years+ - NCT07365098Recruiting
Liver Transplant and the 30-Second Sit-to-Stand Test
This study looks at how well people waiting for a liver transplant can do a simple 30-second test of standing up and sitting down. The goal is to see if this test can help doctors understand your physical strength before surgery.
MalatyaAges 18–65 - NCT07076602Recruiting
Walking and energy use in children with leg amputations
This study looks at how children with a leg amputation walk and how much energy they use when walking. It aims to better understand gait and energy use to improve care and prosthetic fitting.
BerckAges 7–17 - NCT07444593Recruiting
Shin bone transport to heal diabetic foot ulcers
This trial tests whether a surgical technique called transverse tibial bone transport (TTT) can help heal chronic diabetic foot ulcers. TTT involves moving a small piece of the shinbone to encourage new blood vessels to grow to the wound, which may help it close.
Jacksonville, FloridaAges 22 years+ - NCT06667492Recruiting
Leg strength measurement in healthy kids
This study measures leg muscle strength in healthy children ages 5 to 16 to better understand normal development. If your child is developing typically and can follow instructions, they may be able to join.
Lamia, PhthiotisAges 5–16 - NCT07323147Enrolling by invitation
Robot-assisted walking therapy for hip fracture recovery
This study tests whether a robot suit can help older adults walk better after hip fracture surgery. If you are 65 or older and had surgery for a broken hip from a minor fall, you may be able to join.
Beijing, Beijing MunicipalityAges 65–100 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT03442465Recruiting
Study of healing and function after bone reconstruction surgery
This study looks at how well people heal and how well they can move and use the repaired bone after reconstructive surgery for bone tumors. It may help doctors understand what recovery looks like and what could improve function over time.
Basking Ridge, New JerseyAges 4 years+ - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT03663790Recruiting
Gait retraining for knee osteoarthritis movement patterns
This trial tests whether a structured walking retraining program can improve how your leg moves if you have knee osteoarthritis. It may help reduce strain on your lower body during walking by changing walking technique.
Manassas, VirginiaAges 18–80 - NCT06223217Recruiting
New quality-of-life survey for leg artery disease patients
This study tests a new questionnaire (modified VascuQol) to measure how leg artery disease affects your daily life. It aims to create a better tool for doctors to track your symptoms and well-being.
Shanghai, Shanghai MunicipalityAges 18–90
Hear when a new Lower Extremity trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 121 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.