Clinical trials
Lower Extremity clinical trials
Below are recruiting lower extremity clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60 - NCT06747117Recruiting
Removing blood clots in leg arteries with the Indigo system
This study tests a device that vacuums out blood clots from blocked leg arteries, potentially restoring blood flow without open surgery.
Scottsdale, ArizonaAges 18 years+ - NCT07604948Recruiting
Blood Flow Restriction Training for Basketball Recovery
This study tests whether briefly restricting blood flow to the legs (using an arm cuff on the thigh) can help male basketball players recover faster and improve leg strength after games. Researchers want to see if this technique, called ischemic preconditioning, reduces fatigue and speeds healing.
Guangzhou, GuangdongAges 18–25 - NCT07253857Recruiting
Hand and arm therapy for children with cerebral palsy
This study tests a special hand and arm therapy for children with spastic cerebral palsy. The therapy also includes leg exercises to improve movement. It may help your child use their hands and arms better.
Lahore, Punjab ProvinceAges 6–12 - NCT06639802Recruiting
Therapy for balance and coordination in ataxic cerebral palsy
This trial tests a hand-arm and leg therapy program to improve balance and coordination in children with ataxic cerebral palsy. It may help your child move more steadily and confidently.
RawalpindiAges 6–15 - NCT06816836Recruiting
Measuring leg muscle mass to predict hospital stay after cancer surgery
This study uses ultrasound to measure leg muscle mass before surgery for gynecologic cancers, to see if it can predict how long you'll need to stay in the hospital after the operation.
Kolkata, West BengalAges 50–99 - NCT05225792Recruiting
Fast rehab program for leg injuries and amputations
This trial tests a rapid rehabilitation approach for people with certain leg injuries, including amputations and limb salvage, while you are already in standard rehab. It may help improve walking and balance after trauma by using a structured training program.
Rochester, MinnesotaAges 18 years+ - NCT06839885Recruiting
Water Therapy for Swelling in One Leg
This trial tests whether water-based therapy (hydrotherapy) can help reduce swelling in one leg caused by lymphedema. It's for people who have already tried standard lymphedema treatment.
IstanbulAges 18–75 - NCT07592494Recruiting
Arm Exercise Training for Heart Failure With Device
This study compares different types of arm exercises for people with heart failure who have a pacemaker or defibrillator implanted. The goal is to see which exercise approach best improves how well your arms function and help you stay active.
ÇorumAges 18 years+ - NCT06092528Recruiting
Pulmonary rehab for kids with primary immunodeficiency
This study tests whether a pulmonary rehabilitation program helps children aged 6–18 with primary immunodeficiency improve their breathing and physical fitness. If your child has this condition and is not currently having a lung infection or other serious health issues, they may be able to join.
Ankara, ÇankayaAges 6–18 - NCT07365098Recruiting
Liver Transplant and the 30-Second Sit-to-Stand Test
This study looks at how well people waiting for a liver transplant can do a simple 30-second test of standing up and sitting down. The goal is to see if this test can help doctors understand your physical strength before surgery.
MalatyaAges 18–65 - NCT04658693Recruiting
Restore leg sensation in diabetic nerve damage with safe stimulation
This study tests a treatment that delivers mild stimulation to help bring back lower-limb feeling in people with diabetic nerve damage (or an insensate foot) and may also protect nerves. If you qualify and can safely take part in testing and follow-up, it could improve sensation and walking comfort.
Cleveland, OhioAges 18 years+ - NCT06667492Recruiting
Leg strength measurement in healthy kids
This study measures leg muscle strength in healthy children ages 5 to 16 to better understand normal development. If your child is developing typically and can follow instructions, they may be able to join.
Lamia, PhthiotisAges 5–16 - NCT07221019RecruitingPhase 4
Pain relief after leg injury: single shot vs. continuous numbing
This study compares two ways to manage pain after a leg injury: a single injection of a long-lasting numbing medicine (Exparel) versus a small tube that delivers numbing medicine for a few days (catheter). It is for people who have not used strong painkillers before and have a closed leg fracture.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07323147Enrolling by invitation
Robot-assisted walking therapy for hip fracture recovery
This study tests whether a robot suit can help older adults walk better after hip fracture surgery. If you are 65 or older and had surgery for a broken hip from a minor fall, you may be able to join.
Beijing, Beijing MunicipalityAges 65–100 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT03442465Recruiting
Study of healing and function after bone reconstruction surgery
This study looks at how well people heal and how well they can move and use the repaired bone after reconstructive surgery for bone tumors. It may help doctors understand what recovery looks like and what could improve function over time.
Basking Ridge, New JerseyAges 4 years+ - NCT05699174RecruitingPhase 3
Compare two antibiotic routes for infected broken bones after surgery
This Phase 3 trial tests whether giving antibiotics by mouth (PO) works as well as giving antibiotics through a vein (IV) for an infected fracture that has not healed after prior surgery. It may help you understand which approach is safer and more effective for getting the bone to heal.
Indianapolis, IndianaAges 18 years+ - NCT07040683Recruiting
Vacuum dressing for skin grafts on lower leg
This study compares standard wound care to a special vacuum dressing (negative pressure therapy) after skin graft surgery on the lower leg for skin cancer. The goal is to see if the vacuum dressing helps the graft heal better.
MalmöAges 18 years+ - NCT07760363Recruiting
Foot exercise device for leg swelling
This study tests if using a foot pedal device while lying down can help reduce leg swelling in the hospital. It aims to see if this simple exercise can improve comfort and outcomes for people with fluid buildup.
Tulsa, OklahomaAges 18 years+ - NCT07613931RecruitingEarly Phase 1
New Compression Device for Leg Lymphedema Treatment
This study tests a newer version of a pneumatic compression device (a machine that gently squeezes your leg to reduce swelling) for lymphedema—persistent swelling in the lower leg or foot. Researchers want to see if the updated compression settings work better to reduce swelling and improve how your leg feels and functions.
Houston, TexasAges 18 years+ - NCT07754110Recruiting
A therapy for balance and coordination after stroke
This study tests a therapy called HABIT-ILE to see if it helps improve balance and coordination in people who have had a stroke. If you have had a stroke affecting one side of your body, this might help you move better.
Mansehra, KpkAges 40–60 - NCT05646316RecruitingPhase 3
Sentinel lymph node mapping to reduce leg swelling after surgery
This study tests whether a special way of finding lymph nodes during hysterectomy can lower the risk of long-term leg swelling or related dysfunction in people with stage I endometrial cancer. It compares standard lymph node assessment with sentinel lymph node mapping and looks at how this affects day-to-day leg functioning.
Washington D.C., District of ColumbiaAges 18 years+
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Common questions
- Are there clinical trials for lower extremity?
- Yes. Clin2 currently lists 122 recruiting lower extremity studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lower extremity trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lower extremity trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.