Clinical trials
Lung Cancer (Locally Advanced or Metastatic) clinical trials
Below are recruiting lung cancer (locally advanced or metastatic) clinical trials, each written for real people, not researchers. We’re tracking 5,831 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06802835RecruitingPhase 1/Phase 2
EGFR antibody plus immunotherapy and chemo for advanced nasopharyngeal cancer
This trial tests a combination of an EGFR antibody, a PD-1 inhibitor, and chemotherapy for people with nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this new mix can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06807086Recruiting
Online talk therapy for insomnia in cancer survivors
This study tests if online therapy sessions can help cancer survivors with long-term sleep problems (insomnia). It is for people who have finished or are still in active cancer treatment, including those with stable metastatic cancer.
Boston, MassachusettsAges Any age - NCT06807619RecruitingPhase 1
Sotorasib for people with brain tumors needing surgery
This study tests a drug called sotorasib in people with brain tumors who are already scheduled for surgery or a biopsy. It may help find out if the drug can reach and treat the tumor.
Basking Ridge, New JerseyAges 18 years+ - NCT06810804RecruitingPhase 2
Study of NBQ72S for breast cancer that has spread to the brain lining
This trial tests a new drug, NBQ72S, for people with breast cancer that has spread to the lining of the brain or spinal cord (leptomeningeal metastasis). It aims to see if the drug is safe and helpful for these patients.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06813235Recruiting
Sleep improvement program for Chinese cancer survivors
This study tests a step-by-step program to help Chinese cancer survivors with mild to moderate sleep problems. The program adjusts to your needs and aims to improve your sleep without strong medication.
Hong KongAges 18 years+ - NCT06823440Recruiting
Preventing nerve damage from chemo with compressive therapy
This trial tests if wearing compressive therapy (like special sleeves or stockings) during weekly paclitaxel chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. It is for people who have not yet had nerve issues or diabetes.
BrnoAges 18–70 - NCT06827717RecruitingPhase 2
Liposomal irinotecan combo for advanced Ewing sarcoma
This trial tests a combination of three drugs (liposomal irinotecan, temozolomide, and fluzoparib) for people with Ewing sarcoma that has spread or come back after first treatment. The goal is to see if this combination can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06833073RecruitingPhase 2
Study of an mRNA vaccine and BCG for bladder cancer
This trial tests an experimental mRNA vaccine (V940) combined with BCG therapy for people with high-risk non-muscle invasive bladder cancer that hasn't spread. It aims to see if the vaccine can help the immune system better fight the cancer.
Bakersfield, CaliforniaAges 18 years+ - NCT06835049RecruitingPhase 2
Heating therapy before surgery for high-risk soft tissue sarcoma
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
AarauAges 18 years+ - NCT06843967RecruitingPhase 1/Phase 2
Mirdametinib and palbociclib for liposarcoma
This trial tests two targeted drugs – mirdametinib and palbociclib – taken as pills for people with a specific aggressive type of liposarcoma (dedifferentiated liposarcoma) that has spread or can't be removed. The goal is to see if this combination can shrink or slow the tumor.
Basking Ridge, New JerseyAges 18 years+ - NCT06850103RecruitingPhase 2
Chemo, radiation, and immunotherapy for advanced rectal cancer that has spread a little
This trial tests a combination of chemotherapy, radiation, and an immunotherapy drug (serplulimab) for people with rectal cancer that has spread to just a few spots in the body (no more than 5 tumors in up to 2 locations). It aims to see if this approach is safe and effective.
Hangzhou, ZhejiangAges 18–75 - NCT06855784Recruiting
Time-Restricted Eating for Menopause and Breast Cancer
This study tests if time-restricted eating (eating only during a set window each day) can help women with menopausal symptoms, including those who have had hormone-sensitive breast cancer and are on hormone-blocking therapy.
Geneva, Canton of GenevaAges 45–60 - NCT06856213RecruitingPhase 2
Cetuximab with or without weekly paclitaxel for head and neck cancer
This study tests whether adding the chemotherapy drug paclitaxel (Taxol) to the targeted therapy cetuximab (Erbitux) is more effective than cetuximab alone for head and neck cancer that has progressed after initial immunotherapy and chemotherapy. Researchers want to see if the combination can help shrink tumors or slow the disease.
Santiago de Compostela, A CoruñaAges 18 years+ - NCT06857175RecruitingPhase 3
Comparing a new drug to standard chemo for advanced bladder cancer
This trial tests a new drug called BL-B01D1 against standard chemotherapy for people with advanced bladder cancer that has stopped responding to platinum chemo and immunotherapy. The goal is to see if the new drug works better.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06860490RecruitingPhase 2
Liver cancer trial: HAIC plus immunotherapy and anti-angiogenesis
This trial tests a combination of liver-directed chemotherapy (HAIC), an immunotherapy drug (sintilimab), and a drug that blocks blood vessel growth (bevacizumab biosimilar) for advanced liver cancer that hasn't been treated with systemic therapy before. The goal is to see if this triple therapy can shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06883214Recruiting
MiRNA signatures in glioma diagnosis
This study looks at three specific molecules in glioma tumors to understand their role and potentially improve diagnosis. It may help people with glioma by providing more targeted information about their condition.
Rome, RomeAges Any age - NCT06884618RecruitingPhase 1
Study of RO7673396 for advanced solid tumors with RAS mutations
This trial tests a new drug, RO7673396, for people with advanced solid tumors that have a RAS mutation. The goal is to see if the drug is safe and works against the cancer.
Duarte, CaliforniaAges 18 years+ - NCT06891560RecruitingPhase 2
Enfortumab vedotin for adenoid cystic carcinoma
This trial tests a drug called enfortumab vedotin for people with adenoid cystic carcinoma (ACC) that has spread or come back. The drug is given through a vein and may help shrink tumors or slow the cancer.
Basking Ridge, New JerseyAges 18 years+ - NCT06896188RecruitingPhase 1
Study of 9-ING-41 and retifanlimab plus chemo for advanced pancreatic cancer
This trial tests a new combination of two experimental drugs (9-ING-41 and retifanlimab) plus a standard chemotherapy regimen (modified FOLFIRINOX) for people with advanced or metastatic pancreatic cancer who have not yet received treatment for their advanced disease. The goal is to see if this combination is safe and effective.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06906822RecruitingPhase 2
Keytruda plus Padcev for advanced melanoma
This trial tests a combination of two drugs—Keytruda (immunotherapy) and Padcev (a targeted drug that delivers chemotherapy to cancer cells)—for people with advanced melanoma that has stopped responding to standard immunotherapy. The goal is to see if this new pair can shrink tumors or slow the disease.
A Coruña, A CoruñaAges 18 years+ - NCT06907810Recruiting
Study of fat molecules in long-term breast surgery pain
This trial looks at how certain natural fat molecules in your body might relate to long-term pain after breast cancer surgery. It could help doctors better understand and treat chronic pain in the future.
Brussels, Brussels CapitalAges 18 years+ - NCT06908304RecruitingPhase 3
Study of THIO + Cemiplimab vs Chemo for Advanced Lung Cancer
This trial tests a new combination of drugs (THIO and cemiplimab) against standard chemotherapy for people with advanced non-small cell lung cancer who have already tried two prior treatments including immunotherapy and platinum chemo. The goal is to see if the combination helps control the cancer better.
PoznanAges 18 years+ - NCT06908928RecruitingPhase 1
Study of Bulumtatug Fuvedotin for advanced triple-negative breast cancer
This study tests a new drug called bulumtatug fuvedotin for people with triple-negative breast cancer that has spread or come back. It's for those who have already tried certain other treatments, including a taxane and a specific type of antibody-drug conjugate.
Duarte, CaliforniaAges 18 years+ - NCT06914648Recruiting
Liver preparation before surgery study for certain liver cancers
This study tests a procedure called portal vein embolization (PVE) to help grow the healthy part of the liver before surgery. It may be an option for people with certain liver cancers who need more healthy liver tissue before their operation.
New Haven, ConnecticutAges 18 years+
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Common questions
- Are there clinical trials for lung cancer (locally advanced or metastatic)?
- Yes. Clin2 currently lists 5,831 recruiting lung cancer (locally advanced or metastatic) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lung cancer (locally advanced or metastatic) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lung cancer (locally advanced or metastatic) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Locally Advanced or Metastatic Breast Cancer
- Locally Advanced Non-Small Cell Lung Cancer
- Advanced or Metastatic Non-small Cell Lung Cancer
- Colorectal Cancer (Locally Advanced or Metastatic)
- Liver Cancer (Locally Advanced or Metastatic)
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.